Tyrosol and tyrosol bypass salidroside plant extraction and preparation and use thereof

A salidroside plant and plant extract technology, which is applied in the direction of plant raw materials, sugar derivative preparation, plant/algae/fungus/moss components, etc., can solve the problem of low extraction purity of extracts, no tyrosol and rhodiola Glycoside extraction technology, complex components and other issues

Inactive Publication Date: 2008-03-19
江苏中康药物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the complex components of Rhodiola rosea extract and privet extract, the extraction purity of the extracts in the prior art is relatively low, and no extraction of tyrosol and salidroside has been found to meet the technical requirements of industrial production and meet the pharmaceutical requirements. Technology

Method used

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  • Tyrosol and tyrosol bypass salidroside plant extraction and preparation and use thereof
  • Tyrosol and tyrosol bypass salidroside plant extraction and preparation and use thereof
  • Tyrosol and tyrosol bypass salidroside plant extraction and preparation and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Example 1. A tyrosol plant extract, which is extracted from the root or rhizome of Rhodiola rosea, or from the ripe fruit or flower of Ligustrum lucidum or fermented soybean paste and vinegar residue, the extraction steps are as follows,

[0041] (1) Extract 2 times with 60% ethanol, 10 times each time, concentrate until there is no alcohol smell, add 3 times the amount of water and refrigerate overnight, centrifuge to remove the precipitate, adjust the clarified solution to PH=4 with 0.1mol / L hydrochloric acid, refrigerate overnight, Centrifuge to remove precipitation, add AB-8 macroporous resin to the clarified liquid, and the amount of resin is 3 times that of the raw material;

[0042] (2) The macroporous resin column is first eluted with 2 times column volume of deionized water until the effluent is nearly neutral, then eluted with 5 times column volume of 0.1% sodium hydroxide, and then 2 times column volume Wash with water to near neutrality, then elute with 2 t...

Embodiment 2

[0045] Example 2. A tyrosol plant extract, which is extracted from the root or rhizome of Rhodiola rosea, or from the ripe fruit or flower of Ligustrum lucidum, the extraction steps are as follows,

[0046] (1) Extract 3 times with 75% alcohol (respectively 10 times, 8 times, 8 times), concentrate to no alcohol smell, add 8 times the amount of water to refrigerate overnight, centrifuge to remove the precipitate, and adjust the pH of the aqueous solution with 0.5mol / L hydrochloric acid = 3. Refrigerate overnight, centrifuge to remove sediment, and add D101 macroporous resin to the clarified solution, the amount of resin is 2.5 times that of the raw material;

[0047] (2) Elution of the macroporous resin column with 3 times column volume of deionized water until the effluent is nearly neutral, then elution of the macroporous resin column with 3 times column volume of 0.5% sodium hydroxide, and then 3 times column volume Wash with water until nearly neutral, then elute with 0.5m...

Embodiment 3

[0051] Example 3. The pharmacological action experiment of the tyrosol plant extract (hereinafter referred to as tyrosol) that makes by embodiment 1.

[0052] Experimental purpose: Through pharmacological experiments, to determine the basic pharmacological effects of tyrosol.

[0053] 1. Experimental materials

[0054] (1) Drugs and reagents

[0055] Tyrosol, provided by Jiangsu Zhongkang Pharmaceutical Technology Co., Ltd.; Danshen Tablets, 100 tablets / bottle, Shanghai Leiyunshang Pharmaceutical Co., Ltd., batch number: 0404031; Shengmai Capsules, human dosage about 12g (crude drug) / kg, Jiangxihui Ren Pharmaceutical Co., Ltd., batch number: 0412026; soda lime, Shanghai Ludu Chemical Reagent Factory, batch number: 20030612; chloral hydrate: AR, 250g / bottle, Sinopharm Chemical Reagent Co., Ltd., batch number: 20040420; normal saline, Nanjing Small Commercial pharmaceutical factory, batch number: 20050525; fluorouracil injection, 0.25g / 10ml, Tianjin Jinyao Amino Acid Co., Ltd...

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Abstract

The invention discloses an extract of a tyrosol plant, which is extracted from a root or a rhizome of a rhodiola rosea or from a mature fruit or a flower of a glossy privet fruit or from fermented soy sauce or vinegar residue. The invention also discloses an extract preparation of the tyrosol plant and the purpose of the extract preparation. The invention also discloses an extract of a salidroside plant of the tyrosol side product and the preparation and purpose of the extract. The extraction technology of the extracts of the invention is advanced, and the content of the effective components of the extracts is high, and the extracts can be fit for the requirements of the industrialized production technology and the pharmacy.

Description

technical field [0001] The invention relates to a traditional Chinese medicine extract, especially a tyrosol plant extract and its preparation and use. The invention also relates to a tyrosol by-product salidroside plant extract and its preparation and use. Background technique [0002] Tyrosol is found in the roots or rhizomes of the genus Rhodiola (Rhodiola L.) in the Crassulaceae family, or in the mature fruits or flowers of the evergreen tree Ligustrum lucidum A it. aglycone. The following is the structural formula of salidroside: [0003] [0004] Molecular formula of tyrosol: C 8 h 10 o 2 ;Structural formula: [0005] [0006] According to literature reports, Rhodiola rosea extract and privet extract have immune regulation effect, antiviral effect, anti-hypoxia effect, hypoglycemic effect, nerve cell protection effect, liver protection effect, nootropic effect, antioxidant effect, radiation protection function and many other functions. The main active ingr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/41A61K36/185A61K36/48A61K36/00A61P35/00A61P9/10A61P9/00A61P31/12A61P25/28C07H1/08C07C29/74A61K125/00A61K131/00
Inventor 肖伟蔡宝昌李明慧丁岗朱华荣王成生曹亮
Owner 江苏中康药物科技有限公司
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