Jinling common cold preparation and controlled releasing preparations and preparation method thereof

A technology of controlled-release preparations and extraction methods, which is applied in the direction of pill delivery, antiviral agents, anti-infective drugs, etc., can solve the problems of increasing efficiency but not increasing toxicity, slow onset of effect, and small toxic and side effects, so as to improve bioavailability, Fast onset, long-lasting effects

Inactive Publication Date: 2008-06-04
孙蓉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The curative effect of the currently marketed varieties is analyzed as follows: traditional Chinese medicine has the characteristics of slow onset of action, mild effect and low side effects, while western medicine has a quick onset of action, but has relatively high toxicity and side effects; The "preparation process" reflects the respective characteristics of traditional Chinese medicine and western medicine, and does not give full play to the characteristics of "increasing efficiency and reducing toxicity" or "increasing efficiency without increasing toxicity", and it is far from achieving the combination in the "true sense"! Therefore, it is imperative to use the "controlled release technology" to develop secondary Chinese and Western compound preparations that can not only exert the stable and long-lasting curative effect of traditional Chinese medicine, but also exert the rapid curative effect of western medicine for the existing famous and high-quality products with definite curative effect and market space for treating colds.

Method used

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  • Jinling common cold preparation and controlled releasing preparations and preparation method thereof
  • Jinling common cold preparation and controlled releasing preparations and preparation method thereof
  • Jinling common cold preparation and controlled releasing preparations and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0164] The preparation method of tablet of the present invention (making 1000):

[0165] Quick release part:

[0166] Chlorpheniramine 1g Vitamin C10g

[0167] Aspirin 60g plus polyvinylpyrrolidone 10g

[0168] Lactose 10g Sodium hydroxymethyl starch 10g

[0169] Take honeysuckle vine, wild chrysanthemum, and pea root, add water and decoct twice, add 10 times the amount of water for the first time, decoct for 2 hours, add 8 times the amount of water for the second time, decoct for 2 hours, combine the decoction, Filter and concentrate the filtrate to a thick paste, dry and set aside.

[0170] Crush the antelope horn into a fine powder and mix it with the rest of the concentrated buffalo horn powder.

[0171] The above-mentioned drugs and auxiliary materials were mixed and granulated with 95% ethanol, dried, and passed through a 16-mesh sieve for granulation.

[0172] Sustained release part:

[0173] Antelope Horn 1g Concentrated Buffalo Horn Powder 3g

[0174] Honeysuck...

Embodiment 2

[0180] The preparation method of capsule of the present invention (making 1000):

[0181] Quick release part:

[0182] Chlorpheniramine 1g Vitamin C10g

[0183] Aspirin 60g Croscarmellose Sodium 16g

[0184] Hypromellose 10g Microcrystalline Cellulose 12g

[0185] Take wild chrysanthemum, add 12 times the amount of water, use a Soxhlet extractor to extract the volatile oil until the volatile oil no longer increases, add water and decoct the remaining medicinal residues and honeysuckle for 3 times, add 10 times the amount of water for the first time, and decoct Boil for 3 hours; add 8 times the amount of water for the second time, and decoct for 2 hours; add 8 times the amount of water for the third time, decoct for 1 hour, filter, combine the decoction, and concentrate the filtrate to a thick paste, that is, .

[0186] Take bean root, soak in acid water with pH 3.5 for 1 hour, decoct twice, add 10 times the amount of acid water each time, decoct for 2 hours each time, filt...

Embodiment 3

[0197] The preparation method of granule of the present invention (making 1000 bags):

[0198] Quick release part:

[0199] Chlorpheniramine 1g Vitamin C10g

[0200] Aspirin 60g Hydroxymethylcellulose 14g

[0201] Polyvinylpyrrolidone 15g Magnesium stearate 1g

[0202] Take the wild chrysanthemum, add 12 times the amount of water, use a Soxhlet extractor to extract the volatile oil until the volatile oil no longer increases, add water and decoct the remaining medicinal residues and honeysuckle for 3 times, add 12 times the amount of water for the first time, and decoct Boil for 2 hours; add 10 times the amount of water for the second time, decoct for 1 hour; add 8 times the amount of water for the third time, decoct for 1 hour, filter, combine the decoction, and concentrate the filtrate to a thick paste, that is, .

[0203] Take bean root, soak in pH3 acid water for 1.5 hours, decoct twice, add 12 times the amount of acid water for the first time, decoct for 2 hours; add 1...

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Abstract

The invention relates to Jinling cold controlled release preparation and the preparation method thereof. The invention consists of the following components by weight: cornu bubali concentration powder, cornu antelopis, caulis lonicerae, chrysanthemi indici, asiatic moonseed rhizome, aspirin, chlorphenamine and vitamin C. The controlled release preparation in the invention consists of sustained release part and immediate release part; wherein, aspirin, chlorphenamine and vitamin C are used as immediate release part, with the functions of relieving fever and pain, which can treat the early cold symptoms, aiming to cure the disease rapidly and effectively; cornu bubali concentration powder, cornu antelopis, caulis lonicerae, chrysanthemi indici, asiatic moonseed rhizome are used as the sustained release part, which focuses on the aspects such as anti-inflammation, antibiosis, anti-viral infection and regulating immunity, aiming to treat common cold at whole range and recovery stage. The invention has the advantage of integrating rapidness of western medicine with long-lasting of the traditional Chinese medicine, which reaches the real integration of traditional Chinese medicine with western medicine, thus improving bioavailability of the drug.

Description

Technical field: [0001] The invention relates to a golden antelope cold controlled-release preparation for treating colds. Specifically, the controlled-release preparation of the invention consists of a constant-release part and an immediate-release part. The invention also relates to a preparation method of the controlled-release preparation. Background technique: [0002] Common cold and influenza are the most common upper respiratory diseases, mostly caused by viral infections. Rhinoviruses, coronaviruses, and influenza viruses are common. The clinical course of a cold is mostly divided into initial stage, extreme stage, and recovery stage. In the early stage, fatigue and discomfort and nasal catarrhal symptoms are mainly present, such as nasal congestion, nasal itching, sneezing, and runny nose; in the extreme stage, headache, fever, arthralgia and Cough, etc., symptoms and signs at the initial and extreme stages can seriously affect people's quality of life, and bring ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/59A61K9/16A61K9/20A61K9/48A61K9/50A61P31/00A61P31/14A61P31/16A61P11/00A61K35/32A61K31/375A61K31/4402A61K31/616
Inventor 孙蓉张作平衣银萍殷大伟韩艳于晓
Owner 孙蓉
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