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Medicine for treating antibacterial drugs associated enteritis and preparation method thereof

A drug and drug efficacy technology, applied in the field of preparation of drugs for the treatment of antibiotic-associated enteritis or flora-altering enteritis, can solve the problems of high recurrence rate, no drug composition found, high price, etc.

Active Publication Date: 2008-06-04
BEIJING ZHONGYAN TONGRENTANG CHINESE MEDICINE R & D
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, antibiotic-associated diarrhea is more common in clinical practice, and there is currently no effective treatment drug in traditional Chinese and Western medicine. Although vancomycin has a certain inhibitory effect on the pathogenic bacteria, it is expensive and has a high recurrence rate
So far, do not find any reports about the pharmaceutical composition of the present invention

Method used

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  • Medicine for treating antibacterial drugs associated enteritis and preparation method thereof
  • Medicine for treating antibacterial drugs associated enteritis and preparation method thereof
  • Medicine for treating antibacterial drugs associated enteritis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] [Example 1] Preparation of the effective components of the medicine of the present invention

[0028] a) Weigh raw materials: 40 grams of Coptidis Rhizoma, 60 grams of Scutellaria, 60 grams of Codonopsis, 40 grams of fried Atractylodes macrocephala, 40 grams of Poria cocos, 40 grams of Alisma, 40 grams of licorice and 40 grams of woody fragrance, set aside;

[0029] b) Coptis rhizome was extracted three times with 5-7 times of 50%-80% ethanol, each time for 1-3 hours, and the ethanol was recovered to obtain dry extract 1;

[0030] c) Scutellaria baicalensis soaked in warm water, combined with Codonopsis pilosula, Poria cocos, Alisma, licorice and Atractylodes macrocephala (stir-fried) and decocted in water three times, combined the decoction, filtered, and the filtrate was concentrated to a relative density of 1.15-1.20 (50°C), and placed for 24 hour, vacuum drying to obtain dry extract 2;

[0031] d) Add 8 to 10 times of water to the coarse powder of woody incense, st...

experiment example 1

[0034] experiment material:

[0035] drug:

[0036] The drug efficacy component of the present invention prepared in Example 1: every milliliter contains 5.0 grams of crude drug, and is diluted to a corresponding concentration with an appropriate amount of distilled water before use; penicillin G potassium salt injection: 400,000 units; gentamicin sulfate injection : 40,000 units; demethyl vancomycin tablet: 0.5g / tablet; berberine hydrochloride tablet: 0.1g / tablet; aspirin tablet: 0.5g / tablet.

[0037] Strains:

[0038] Human embryonic lung diploid subcultured cells 2BS; 24 clinical isolates of Staphylococcus aureus; 23 strains of Clostridium difficile, including standard strains and clinical isolates; 9 hamster isolates.

[0039] animal:

[0040] Golden hamster: half male and half female, weighing 70-80 grams; Wistar rat: male, weighing 150-160 grams; Kunming mouse: female and male, weighing 18-20 grams.

[0041] instrument:

[0042] GasPak anaerobic tank; inverted micro...

Embodiment 2

[0080] [embodiment 2] capsule preparation of medicine of the present invention

[0081] a) Weigh raw materials: 30 grams of Coptidis Rhizome, 30 grams of Scutellaria Baicalensis, 30 grams of Codonopsis Radix, 10 grams of fried Atractylodes macrocephala, 30 grams of Poria cocos, 30 grams of Alisma, 10 grams of licorice and 10 grams of woody fragrance, set aside;

[0082] b) Coptidis rhizome, extracted three times with 5-7 times of 50%-80% ethanol, each time for 1-3 hours, and recovered ethanol to obtain dry extract 1;

[0083] c) After soaking Scutellaria baicalensis in warm water, combine it with Codonopsis pilosula, Stir-fried Atractylodes macrocephala, Poria cocos, Alisma, and licorice, add water and decoct three times, combine the decoction, filter, concentrate the filtrate to a relative density of 1.10-1.30 (50°C), and place it for 24 hours. Concentrate the supernatant under reduced pressure to a clear extract with a relative density of 1.10-1.30 (80°C), and dry it under r...

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PUM

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Abstract

The invention discloses a medicine for treating antibiotic-associated diarrhea. The effective components contained in the invention are prepared by rhizoma coptidis, radix scutellariae, radix codonopsitis, rhizoma atractylodis alba, Indian buead, liquoric root, rhizoma alismatis and costus root according to a certain proportion by weight. The effective components can be prepared into any common oral formulation. The invention has the functions of clearing heat and dampness, reinforcing the spleen, replenishing qi, alleviating the symptoms of diarrhea and bellyache and facilitating the recovery of alteration of intestinal flora, and can treat the antibiotic-associated diarrhea or intestinal flora alterative enteritis. The invention further discloses the preparation method of the medicine.

Description

【Technical field】 [0001] The invention relates to a medicine with the functions of clearing away damp-heat and invigorating the spleen and replenishing qi, belonging to the field of traditional Chinese medicine, and a preparation method thereof. The invention also relates to a preparation method of the medicine and a medicine for treating antibiotic-associated enteritis or flora-altering enteritis the use of. 【Background technique】 [0002] With the widespread use of antibiotics, diarrhea or colitis associated with antibiotics occurs frequently. Long-term use of broad-spectrum antibiotics, high-dose combined use, or frequent replacement of antibiotics can cause intestinal ecological imbalance, weaken intestinal colonization resistance, cause diarrhea, and even pus and blood in the stool. Pathological studies have shown that this type of diarrhea is a necrotic inflammation of the colon and small intestinal mucosa. enteritis" or "flora alternation enteritis". [0003] The i...

Claims

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Application Information

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IPC IPC(8): A61K36/884A61K9/16A61K9/20A61K9/48A61P1/12A61P1/00
Inventor 叶祖光
Owner BEIJING ZHONGYAN TONGRENTANG CHINESE MEDICINE R & D
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