Blood compatibility material with micro nano coupling interface structure and its manufacturing method

Abstract

The invention relates to a material with blood compatibility and a structure of micro-nanometer coupling interfaces, and surface structure of the material consists of folds in microns and heaves in nanometers, wherein, the heaves in nanometers are scattered randomly on the folds and in the places between adjacent folds. The preparation method of the material with blood compatibility includes following steps: firstly, a template with nanometer particles closely arranged is constructed on a substrate by using a method of molecular self-assembly of a solution; secondly, liquid macromolecules are poured on the template and solidified; a macromolecule film is separated from the template and placed into a hydrophobing agent for soaking, and then taken as a first film; the first film is taken as a template for making a second film; the second film is oxidized in a plasma cleaner; finally the second film is twisted to get the material with blood compatibility and a structure of micro-nanometer coupling interfaces of the invention. From testing experiments, the fact that activated blood platelet hardly adheres to the structure of micro-nanometer coupling interfaces can be seen, which greatly reduces possibility of blood coagulation and the formation of thrombosis, and consequently blood compatibility of the material is markedly improved.

Description

technical field [0001] The invention relates to a blood-compatible interface medical artificial material, in particular to a blood-compatible material with a micro-nano coupling interface structure, and a preparation method thereof. Background technique [0002] Blood coagulation is a complex process. Although it can temporarily avoid serious blood loss in the case of human injury, the blood coagulation system can also be activated when it comes into contact with foreign substances, which will bring new benefits to the use of medical artificial materials. have very adverse effects. Existing medical artificial materials will cause different degrees of coagulation when they come into contact with blood. For example, the artificial blood vessels currently widely used in clinical practice are made of polyester or polytetrafluoroethylene materials, which will cause different degrees of coagulation and thrombus formation, which will lead to blood vessel blockage, blood stagnation...

AI Technical Summary

Problems solved by technology

For the latter, it is often modified by coating antithrombotic drugs (anticoagulants) on the surface of materials without blood compatibility or poor compatibility, in order to reduce the occurrence of blood coagulation, but this method uses After anticoagulants such as heparin enter the blood circulation, they will interfere with the self-stabilization of the blood coagulation system and bring many side effects to patients, such as bleeding and thrombocytopenia. to reduce the adhesion of platelets; or to improve the blood compatibility of the material by transplanting endothelial or mesothelial cells on the surface of the material, but the specific cells will cause an immune response and cause the patient to reject the implant. It has to spend time and high cost to cultivate special cell materials for each individual. In addition, the adhesion between cells and materials will weaken with time, and the cells will fall off and the expected effect will not be achieved.

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