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External and internal administration disintegrating tablets for treating oral ulcer and preparing method thereof

A technique for orally disintegrating tablets and oral ulcers, applied in the field of orally disintegrating tablets for oral and external use in the treatment of oral ulcers and its preparation, can solve the problems of slow onset, fast onset and easy recurrence, and achieve small bubbles and ensure effective Effects of drug concentration and time, killing and inhibiting reproduction and spread

Inactive Publication Date: 2012-04-25
王国义 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is still a problem that we need to solve to make up for the shortcomings of simple systemic drug treatment of oral ulcers that are not easy to relapse after healing but slow onset of action, and simple topical drug onset of effect is fast and easy to relapse

Method used

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  • External and internal administration disintegrating tablets for treating oral ulcer and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0048] The orally disintegrating tablet for external use and oral administration for the treatment of oral ulcers is made of the following components:

[0049] 1. Raw materials - 50g prepared according to the content of the best effective components of the drug;

[0050] 2. Filling agent - mannitol 71g, microcrystalline cellulose 19g;

[0051] 3. Disintegrant - 16g of erythritol (which also acts as a flavoring agent), 7g of sodium carboxymethyl starch;

[0052] 4. Flavoring agent - mint essence 0.4g

[0053] 5. Glidant—micronized silica gel 4g;

[0054] 6. Lubricant - magnesium stearate 0.6g;

[0055] 7. Effervescent agent - citric acid 18g, sodium bicarbonate 14g;

[0056] The total amount is 200g, compressed into 1000 tablets, each tablet contains 200 mg, the orally disintegrating tablet of the present invention is put into the patient's oral cavity, and the tablet disintegrates completely within 40 seconds. Contact with the ulcer surface to achieve the effect of extern...

Embodiment approach 2

[0058] The orally disintegrating tablet for external use and oral administration for the treatment of oral ulcers is made of the following components:

[0059] 1. Raw materials - 50g prepared according to the content of the best effective components of the drug;

[0060] 2. Filling agent - mannitol 56g, microcrystalline cellulose 18g;

[0061] 3. Disintegrant - erythritol (also acts as a flavoring agent) 23g, cross-linked polyvinylpyrrolidone 9g;

[0062] 4. Flavoring agent - orange essence 0.6g

[0063] 5. Glidant - micronized silica gel 3g;

[0064] 6. Lubricant - magnesium stearate 0.4g;

[0065] 7. Effervescent agent - citric acid 24g, sodium bicarbonate 16g;

[0066] The total amount is 200g, compressed into 1000 tablets, each with a content of 200mg, the orally disintegrating tablet of the present invention is put into the patient's oral cavity, and the tablet disintegrates completely within 35 seconds. Contact with the ulcer surface to achieve the effect of externa...

Embodiment approach 3

[0068] The orally disintegrating tablet for external use and oral administration for the treatment of oral ulcers is made of the following components:

[0069] 1. Raw materials - 50g prepared according to the content of the best effective components of the drug;

[0070] 2. Filling agent - mannitol 53g, microcrystalline cellulose 20g;

[0071] 3. Disintegrant - erythritol (also acts as a flavoring agent) 29g, cross-linked hydroxymethylcellulose sodium 10g;

[0072] 4. Flavoring agent—strawberry essence 0.3g

[0073] 5. Glidant - micronized silica gel 5g;

[0074] 6. Lubricant - magnesium stearate 0.7g;

[0075] 7. Effervescent agent - citric acid 19g, sodium bicarbonate 14g;

[0076] The total amount is 200g, compressed into 1000 tablets, each tablet has a content of 200mg, the orally disintegrating tablet of the present invention is put into the patient's oral cavity, and the tablet disintegrates completely within 30 seconds. Contact with the ulcer surface to achieve the...

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Abstract

The invention relates to an external and internal oral disintegrating tablet for treating dental ulcer and the preparation method, which comprises bee glue, indigo pulverata levis, peppermint, camphor, liquorice, borneol, borax, Chinese goldthread and plant soot having useful treatment quantity and medicine excipient that can rapidly release medicament by disintegration in the mouth. The disintegrating time in the mouth is within 40 seconds. Wherein, the medicine excipient includes bulking agent, disintegrating agent, corrigent, glidant, lubricant and effervescent. The invention is characterized in that the oral disintegrating tablet for curing dental ulcer has the integrated external and internal medicine taking function.

Description

Technical field: [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to an orally disintegrating tablet for external use and oral administration for treating oral ulcers and a preparation method thereof. technical background: [0002] Oral ulcers and recurrent oral ulcers are the most common diseases in oral mucosal diseases, with a higher incidence rate. Western medicine mainly treats the symptoms, and treats the symptoms rather than the root cause. The ulcers are not easy to heal or tend to recur after temporary healing, and some drugs have serious side effects, which cause unnecessary damage to the human body. Theories of traditional Chinese medicine believe that its pathogenesis is caused by accumulated heat in the heart and spleen, steaming of stomach fire, hyperactivity of fire due to deficiency of yin, and steaming of toxic heat in the mouth and tongue. Traditional Chinese medicine treatment of oral ulcer is...

Claims

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Application Information

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IPC IPC(8): A61K36/718A61K36/54A61K36/534A61K36/484A61K36/19A61K36/00A61K35/64A61K33/22A61K31/045A61K9/20A61P1/02A61K31/125A61K35/644
Inventor 王国义阎俊新徐彬
Owner 王国义
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