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Preparation of orally-administered protolysate

A technology of hydrolyzing protein and protease, which is applied in the field of enzymatic protein hydrolyzing, can solve the problems of easy loss of autolytic hydrolytic enzyme activity, easy inactivation of autolytic hydrolytic enzyme, and long reaction time, so as to improve physical decline, enhance hematopoietic function, The effect of convenience

Inactive Publication Date: 2008-09-17
广西宝瑞坦广明制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many sources of enzymes in enzymatic hydrolysis. Various hydrolytic enzymes in biological tissues can be used to decompose cell tissues, and exogenous enzymes suitable for the reaction system can also be added to decompose cell tissues. There are many types of hydrolytic enzymes with different activities, and they will also be affected by other characteristics in the body. The activity of autolytic hydrolytic enzymes in the body is easy to lose
Moreover, using the autolyzed hydrolase present in the body to hydrolyze protein has the disadvantages of long reaction time, low efficiency, low yield, and easy inactivation of the autolyzed hydrolase.

Method used

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  • Preparation of orally-administered protolysate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Mix 30kg of beef and 70kg of soybean meal in a container, add 200kg of water, stir evenly, boil for 30 minutes, cool in a water bath to 38°C, add 60kg of pancreas, and hydrolyze for 3 hours at a temperature of 45°C and adjust the pH to 5.5 with ammonia water. Obtain a hydrolyzate; filter the hydrolyzate, discard the filter residue, boil the filtrate, refrigerate at 0-5°C for 5 hours, and filter to collect the supernatant. Concentrate the above-mentioned filtrate under reduced pressure at 80°C until the specific gravity is 1.05-1.15, stop the concentration, and filter to obtain the hydrolyzed protein concentrate. Spray drying: Spray drying under the condition of air inlet temperature 165-170°C and outlet air temperature 100-105°C to obtain white oral hydrolyzed protein. It can be used for sub-package, and the sub-package specification is 5g / bag, 10g / bag, 15g / bag, and it is packaged into finished powder.

Embodiment 2

[0021] Mix 10kg of crocodile meat and 90kg of soybeans in a container, add 50kg of water, stir evenly, boil for 30 minutes, cool in a water bath to 38-40°C, add 3kg of protease, and hydrolyze at a temperature of 30°C and adjust the pH to 6.5 with ammonia water for 3 hours to obtain a hydrolyzate; filter the hydrolyzate, discard the filter residue, boil the filtrate, refrigerate at 0-5°C for 5 hours, and filter the supernatant. Spray drying: Spray drying under the condition of air inlet temperature 165-170°C and outlet air temperature 100-105°C to obtain white oral hydrolyzed protein. It can be used to pack 0# capsules. With 60 grains / bottle, pack and get the capsule product.

Embodiment 3

[0023] Mix 40kg of beef and 60kg of soybean meal in a container, add 300kg of water, stir evenly, boil for 30 minutes, cool in a water bath to 48-50°C, add 6kg of protease, and hydrolyze for 3 hours at a temperature of 10°C and adjust the pH to 6.5 with ammonia water , to obtain a hydrolyzate; filter the hydrolyzate, discard the filter residue, boil the filtrate, refrigerate at 0-5°C for 5 hours, and collect the supernatant by filtration. Spray drying: Spray drying under the condition of air inlet temperature 165-170°C and outlet air temperature 100-105°C to obtain white oral hydrolyzed protein. Take 85% protein powder, 5% sweetener, 10% dextrin, add appropriate amount of dextrin slurry to make granules, dry to obtain dry granules, and the packaging specifications are 5g / bag, 10g / bag, 15g / bag Bags, packaged to obtain finished granules.

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Abstract

The invention discloses a preparation method of an oral hydrolysis protein. Animal protein 20 to 50 weight account and vegetable protein 50 to 80 weight account are arranged in the reactor for mixing, adding three times amount of water, stirring uniformly, boiling, cooling, adding proteinase or pamcreatin, hydrolysis, so that the hydrolysis liquid is acquired; filtering, boiling the filtrate, refrigerating, leaching the supernatant, then the filtrate is depressurized and concentrated under 80 centigrade to the specific gravity 1.05 to 1.15, filtering, so that the hydrolysis protein concentration liquid is acquired; spray drying, and the white oral hydrolysis protein is acquired. The total nitrogen rate of the hydrolysis protein manufactured by the method of the invention is up to more than 12 percent, and the rate of return of the amino acid is up to more than 8 percent. The invention is used for the clinical medicine or the addition agent of nutritional food, has high nutrition, easy absorption and popularization. The invention is clinically used for hypoproteinemia, and dystrophia and malnutrition caused by various diseases, also used for burn, fracture and malunion of wound after operation. The invention has the advantages of obvious therapeutic effect, good taste, convenient take, big market requirement and significant economic benefit.

Description

technical field [0001] The invention relates to a method for enzymatically hydrolyzing protein, in particular to a method for preparing orally hydrolyzed protein. Background technique [0002] At present, the protein hydrolysis technology at home and abroad mainly adopts three kinds of process methods: acid hydrolysis method, alkali hydrolysis method and enzyme hydrolysis method. Among them, acid hydrolysis and alkali hydrolysis belong to chemical hydrolysis, while enzymatic hydrolysis belongs to biological enzyme hydrolysis. The acid hydrolysis method is usually hydrolyzed with a strong acid, namely sulfuric acid or hydrochloric acid. The molar concentration of the acid is 6 mol / liter, and the hydrolysis is carried out for more than 20 hours at a high temperature of 110°C. Afterwards, asparagine and glutamic acid were completely hydrolyzed into aspartic acid and glutamic acid respectively, and tryptophan was completely destroyed; serine and threonine were partially hydroly...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/02A61K9/10A61K9/14A61K9/16A61K9/48A61K9/20A23L1/305A61P3/02A61P37/04A61P7/06A61P7/00A61K38/01A23L33/18
Inventor 钟恒费善芬
Owner 广西宝瑞坦广明制药有限公司
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