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Bioactive aquagel-conductive polymer nanometer composite material and synthetic material thereof

A nano-composite material, conductive polymer technology, applied in the direction of conductive materials dispersed in non-conductive inorganic materials, etc., can solve the problems of difficult processing, unfavorable acquisition of nutrients, poor mechanical properties, etc., to achieve short curing time, geometric The effect of easy shape control and low reaction heat

Inactive Publication Date: 2008-10-08
XIAMEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as a bioactive material, hydrogel has to solve several problems: (1) Although the gel material is easy to seed cells, if there are no interconnected pores inside, it is not conducive to the cells inside the material to obtain nutrients; (2) as a scaffold Materials, degradability and biocompatibility are two important performance requirements. Although natural polymers have good biocompatibility, they have poor mechanical properties and are not easy to process and shape.

Method used

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  • Bioactive aquagel-conductive polymer nanometer composite material and synthetic material thereof
  • Bioactive aquagel-conductive polymer nanometer composite material and synthetic material thereof
  • Bioactive aquagel-conductive polymer nanometer composite material and synthetic material thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0026] Embodiment 1: Synthesis of ethylene glycol-lactic acid block copolymer gel and polyaniline nanocomposite:

[0027] (1) Synthesis of ethylene glycol-lactic acid block copolymer:

[0028] Under the protection of nitrogen, take 10g PEG (number average molecular weight 200) and 36gdl-lactic acid, and add 23mg of tin octoate into a 100ml three-neck round bottom flask. The reaction mixture was stirred under vacuum at 200°C for 4h, then lowered to 160°C, continued to stir for 2h, and finally cooled to room temperature to obtain an ethylene glycol-lactic acid block copolymer, which was dissolved in dichloroethane and used without Precipitate with water and ether, filter and dry to obtain a purified ethylene glycol-lactic acid block copolymer. From image 3 As can be seen in the SEM photo of A, the synthesized hydrogel membrane material exhibits a honeycomb shape, and these penetrating holes provide a composite space for the conductive polymer.

[0029] (2) Synthesis of ethyl...

Embodiment 2

[0034] Embodiment 2: Synthesis of ethylene glycol-glycolide block copolymer gel and polypyrrole nanocomposite material:

[0035] (1) Synthesis of ethylene glycol-glycolide block copolymer:

[0036] Under nitrogen protection, take 20g PEG (number average molecular weight 400) and 22.8g glycolide (0.2mol, M144), and add 25mg tin octoate into a 100ml three-neck round bottom flask. The reaction mixture was stirred in vacuum at 190°C for 5h, then lowered to 150°C, stirred for 4h, and finally cooled to room temperature. The ethylene glycol-glycolide block copolymer is obtained, and the product is dissolved in dichloroethane, precipitated with anhydrous ether, filtered, and dried to obtain a purified ethylene glycol-glycolide block copolymer. From image 3 As can be seen in the SEM photo of B, the synthesized hydrogel membrane material exhibits a honeycomb shape, and these penetrating holes provide a composite space for the conductive polymer.

[0037] (2) Synthesis of ethylene gl...

Embodiment 3

[0043] Embodiment 3: Synthesis of ethylene glycol-ε-caprolactone block copolymer gel and polyaniline nanocomposite material:

[0044] (1) Synthesis of ethylene glycol-ε-caprolactone block copolymer:

[0045] Under nitrogen protection, take 30g PEG (number average molecular weight 600) and 45.6gε-caprolactone (0.4mol, M114), and add 48mg tin octoate into a 100ml three-neck round bottom flask. The reaction mixture was stirred under vacuum at 210°C for 3h, then lowered to 170°C, continued to stir for 1.5h, and finally cooled to room temperature. To obtain ethylene glycol-ε-caprolactone block copolymer, dissolve the product in dichloroethane, precipitate with anhydrous ether, filter, and dry to obtain purified ethylene glycol-ε-caprolactone block copolymer . From image 3 It can be seen in the SEM photo of C that the synthesized hydrogel membrane material exhibits a honeycomb shape, and these penetrating holes provide a composite space for the conductive polymer.

[0046] (2) ...

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Abstract

A hydrogel-conductive polymer nano-composite material with biological activity and the synthesis method relate to a biological activity material; firstly, polyethylene glycol and hydroxy acid are synthesized to obtain glycol-hydroxy-acid block copolymer under the catalysis of tin octoate; the copolymer, acryloyl chloride and triethylamine are reacted to get glycol-hydroxy-acid block copolymer terminated with acrylic group; the copolymer is then dissolved in water to get gel through photoinitiated crosslinking or free radical crosslinking; finally, the gel is swelled with pyrrole or aniline monomer solution to get the nano-composite material of the glycol-hydroxy-acid block copolymer and the polypyrole or polyaniline through the polymerization under the effect of initiators. Through the copolymerization with hydroxy acid, PEG is endowed with gel system biodegradability; besides, the honeycomb holes of the hydrogel film material can provide composite spaces for conductive polymers; the biological activity of the polypyrole and polyaniline enables the hydrogel to be endowed with biological activity after combination and has nano-enhancing effects to the gel system.

Description

technical field [0001] The invention relates to a nanocomposite material, in particular to a biodegradable bioactive hydrogel-conductive polymer nanocomposite material and a synthesis method thereof. Background technique [0002] Professor Hench, the inventor of bioglass, clearly pointed out in Science magazine (Hench L L, Polak J M.Science, 2002, 295: 1014-1017) that the third generation of biomaterials will not be biologically inert materials nor simply biodegradable materials, but bioactive materials with both degradability and tissue cell-inducing activity. The high water content of the hydrogel is conducive to the diffusion supply of nutrients and oxygen and the discharge of waste generated by cells; in the biological environment, the interfacial tension is low and the biocompatibility is good; and it can be changed by external environmental signals, such as pH value, Ionic strength, temperature, electrical signal, etc. control the volume change; in addition, the mecha...

Claims

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Application Information

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IPC IPC(8): C08L67/00C08L79/04C08L79/02C08G63/66C08G63/91C08J3/24C08G73/04C08G73/02H01B1/20
Inventor 许一婷瞿波邓远名马莹莹戴李宗
Owner XIAMEN UNIV
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