Hollow microsphere containing silicon magnetism and preparation method and use thereof

A magnetic and hollow technology, used in the preparation of microspheres, magnetic materials, magnetic objects, etc., can solve the problems of inability to form a stable dispersion system, high density, easy aggregation and precipitation, etc.

Inactive Publication Date: 2009-01-07
SHANGHAI HUAMING HI TECH GRP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, due to the anisotropic dipole moment effect between the magnetic nanoparticles, it is easy to reunite, and the magnetic particles are often composed of metals or metal oxides, which have a high density and are prone to aggregation and precipitation in the human body, so they cannot form Stable dispersion system, its application in biomedicine is greatly limited

Method used

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  • Hollow microsphere containing silicon magnetism and preparation method and use thereof
  • Hollow microsphere containing silicon magnetism and preparation method and use thereof
  • Hollow microsphere containing silicon magnetism and preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Take 0.07mol FeCl respectively 3 ·6H 2 O and 0.04mol FeSO 4 ·7H 2 O is added with water to form a 0.5mol / L solution, mixed evenly, poured into a four-necked flask and stirred under nitrogen protection, and then 24ml of NH 3 ·H 2 O, aged at 90°C for 30min after the dropwise addition. After the reaction is over, use a strong magnet to hold the bottom of the flask until the magnetic Fe in the system 3 o 4 After sinking, pour off the upper waste liquid, wash repeatedly with deionized water, make the pH of the solution=7, add an appropriate volume of water to adjust Fe 3 o 4 The solid content is up to 6%.

[0039] Fe 3 o4 The morphology of the particles was observed, and the results were as follows figure 1 shown.

[0040] Add 0.4g APS, 0.1g SDS and 120ml double-distilled water into a four-neck flask equipped with mechanical stirring, reflux condenser, and nitrogen protection, stir for 10min, then add 20ml St, nitrogen protection, heat to 70°C for one hour, slowly...

Embodiment 2

[0049] Add 0.4gAPS and 0.8gNH 4 HCO 3 and 120ml of double-distilled water, stirred for 10min, then added 20ml of St, nitrogen protection, heated to 70°C for one hour, slowly added 4g of silane coupling agent KH-570, continued to react for 9 hours, cooled and stood still after the reaction was completed, and obtained White lotion, ready to use.

[0050] Take 1.8g of the above-mentioned white emulsion to the Erlenmeyer flask, add 50ml of absolute ethanol, 7ml of water and 0.7g of PVP, add 1ml of ammonia water after ultrasonication for 30min, stir magnetically, slowly add TEOS, continue stirring for 3 hours after the dropwise addition, and obtain PS / SiO 2 Organic-inorganic composite microspheres (MPSi).

[0051] Place the above MPSi microspheres in a centrifuge (V=3000rpm) for centrifugation, pour off the upper liquid, add double distilled water and continue centrifuging, repeat this operation 4 times, wash the sample to remove excess polystyrene, ammonia water, etc. Dispers...

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Abstract

The invention provides a hollow silicon magnetic microsphere, as well as the preparation method and the application thereof. The hollow silicon magnetic microspheres have the preparation method that a polystyrene/silicon dioxide composite microsphere is used as a core; Fe3O4 coats the periphery of the core through the layer-by-layer self-assembly method; then, a PS/SiO2/Fe3o4 polymeric magnetic composite nanosphere is obtained, and polystyrene is removed through the high temperature sintering method, thereby forming a magnetic material with hollow structure; the inner layer of the hollow magnetic material is SiO2, and the stability is good, thereby the material is not easy to collapse at high temperature; furthermore, the specific surface area of the material can be improved, and the material is a monodisperse hollow magnetic microsphere material. The method has the advantages of low cost and good repetitiveness. The obtained product not only can be used as a magnetic targeting drug carrier material, but also can be used in the biological and the medical fields such as biosensors, immunologic diagnosis, drug delivery and tumor targeting therapy as well as DNA isolation, etc.

Description

technical field [0001] The present invention relates to magnetic hollow microspheres and a preparation method thereof, in particular to a method for preparing polystyrene-silicon dioxide-ferric oxide multilayer composite particles with a core / shell structure and a method for preparing Si-containing magnetic microspheres with a hollow structure Methods and uses. Background technique [0002] Because magnetic polymer microspheres have many characteristics and magnetic responsiveness of polymer microspheres at the same time, they can not only endow them with surface functional groups (such as -OH, -NH, etc.) 2 , -COOH), and can be separated conveniently and quickly under an external magnetic field, so magnetic polymer microspheres have gradually developed since the 1970s and have been widely used in various fields such as biology and medicine. [0003] Because the magnetic microsphere responds to the external magnetic field, the magnetic microsphere can move directional in the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/14H01F1/113
Inventor 陈建定张晓俊宣昭峰马新胜吴秋芳於定华
Owner SHANGHAI HUAMING HI TECH GRP
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