Novel fermentation tank

Abstract

The present invention discloses a novel fermentation tank, which comprises a tank body, a membrane filter and a pipeline; wherein, the membrane filter is arranged inside the tank body; one end of the pipeline is connected with the membrane filter in the tank; the other end of the pipeline leads out of the tank or leads out of the tank through a hollow stirring shaft. The membrane filter can be arranged on the wall of the tank through the pipeline or on the hollow stirring shaft, and the included angle between the membrane filter and the longitudinal axis of the tank is between 0 degree and 90 degrees. In the process of bio-fermentation, the fermentation tank can carry out membrane separation, the positive pressure inside the fermentation tank or / and the negative pressure outside the fermentation tank ensure that liquid-phase material can permeate the membrane and pass through the pipeline to reach other devices outside the fermentation tank, and suspended cells and intercepted granules are intercepted in the fermentation tank to keep fermenting. The novel fermentation tank utilizes the characteristic of the combination of the fermentation tank and the membrane separation, to realize the coupling of cell culture and product abstraction. The fermentation tank does not affect the growth and metabolism of cells, the reaction effect is good, the biochemical reaction system is stable, moreover, the cost is low, investment is little, and the fermentation tank is applicable to biological reaction.

Description

technical field [0001] The invention relates to an enzymatic or microbiological device, in particular to a biofermentation tank using membrane separation technology. Background technique [0002] Membrane separation technology has the following advantages: it is carried out at room temperature and the conditions are mild; there is no phase change of materials; low energy consumption; simple equipment and convenient operation and control. Membranes and membrane technologies have been widely used in chemical, pharmaceutical, food and beverage, electronics and biochemical industries. Membrane bioreactor (Membrane Reactor, MBR), an integrated system formed by the organic combination of membrane and bioreactor, has become a research hotspot in recent years. [0003] A variety of membrane bioreactors have been studied so far. The earliest membrane bioreactor is for the application of water treatment, and it is also the most mature membrane bioreactor in application so far, but t...

AI Technical Summary

Problems solved by technology

The earliest membrane bioreactor was aimed at the application of water treatment, and it is also the most mature membrane bioreactor in application so far, but this type of reactor is not suitable for the so-called biological fermentation, which is different from the purpose of the present invention

Existing membrane bioreactors cannot fully meet the requirements of biological fermentation production and application

Lin Xiao's "Inorganic Membrane Bioreactor" (ZL 03221776.5) and Lu Fuping's "Using Inorganic Membrane to Realize Microbial In-Situ Separation and Fermentation Method" (CN 1908176A) both place the membrane outside the fermenter, and the membrane and the fermenter It is a membrane circulation fermenter through pipelines connected in series; the disadvantage of this type of membrane bioreactor is that when the cells are in the membrane modules and pipelines, conditions such as dissolved oxygen cannot be controlled, and the pump produces violent agitation for the fluid, which is easy to affect cell growth and Metabolism causes damage and easily destroys the stability of the biochemical reaction system

Some people also put organic hollow fiber membranes in fermentation tanks, but these membranes have low mechanical strength, low flux, small processing capacity, difficult cleaning, poor chemical stability, short service life, and are not suitable for use in large bioreactors. use

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