Anti influenza use of main chemical component and active component in scabriculous herbamoslae
A technology of active ingredients and Fructus chinensis, which is applied in medical preparations containing active ingredients, plant/algae/fungus/moss ingredients, antitoxins, etc., can solve the complex drug preparation process, drug-resistant virus strain central nervous system No drug research results, etc.
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0061] Embodiment 1: Establish neuraminidase inhibitor screening model (references: Potier, M., L.Mameli, M.Belislem, L.Dallaire, and S.B.Melanxon. Fluorometric assay of neuraminidasewith a sodium (4-methylumbelliferyla-D-N -acetylneuraminate)substrate.Anal.Biochem., 1979,94:287-296.), by evaluating the neuraminidase inhibitory activity of 100,000 samples in the sample bank, it was found that the water extraction part of A. Acidase inhibitory activity, its IC 50 1 ~ 4ug / ml.
Embodiment 2
[0062] Example 2: After drying and pulverizing 30kg of the whole herb of A. chinensis, extract 3 times with 85% ethanol (2h, 1h×2), combine the extracts, evaporate to dryness under reduced pressure, and obtain the total ethanol extract (ER-ethanol total extract, 1.675kg), and then dissolved in water, extracted with petroleum ether to obtain the petroleum ether part (ER-petroleum ether layer, 0.012kg), and the remainder was extracted with ethyl acetate and n-butanol respectively to obtain the ethyl acetate part ( ER-ethyl acetate layer, 0.040kg) and n-butanol part (ER-n-butanol layer, 0.057kg), and finally the water layer part (ER-water layer, 0.725kg).
Embodiment 3
[0064] Petroleum ether is further separated to obtain betulinic acid, oleanolic acid and ursolic acid,
[0065] The ethyl acetate fraction (235.3 g) was further separated to obtain apigenin (55 mg), luteolin (113 mg), apiin (15 mg), luteolin (35 mg), and luteolin- 3'-glucuronic acid methyl ester (luteolin-3'-glycuronic methyl ester, 19mg), and lignans (27mg) and other components. The separation and purification results of Example 3 show that 3 triterpenoids, 5 flavonoids and 1 lignan are the main chemical components of the traditional Chinese medicine.
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com