Nano-granules reinforced ultra-high molecular weight polyethylene artificial joint material and production method thereof

An ultra-high molecular weight, nanoparticle technology, applied in the field of materials for implanted devices, can solve the problems of difficulty in improving the wear resistance of UHMWPE and difficult long-term use, and achieve the effects of improving lubrication, wetting and reducing wear.

Inactive Publication Date: 2009-04-01
NANJING UNIV OF SCI & TECH
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

Tests have shown that γ-ray irradiation crosslinking can increase the wear resistance of UHMWPE on a hip simulator by more than 90% (SM Kurtz, OK Muratoglu, M Evans, AA Edidin. Advances in the processing, sterilization, and crosslinking of ultra -high molecular weightpolyethylene for total joint arthritis.Biomaterials 1999; 20:1659-1688.), but γ-ray irradiation is difficult to improve the wear resistance of UHMWPE on the knee joint simulator (A.Wang, A.Essner, V.K.Polineni , C.Stark and J.H.Dumbleton, Tribology International 1998, 31, (1-3): 17-33), and γ-ray irradiation increases the overall brittleness of the material; electron beam irradiation can enhance the wear resistance of UHMWPE , but electron beam irradiation causes a deeper oxide layer on the surface of UHMWPE, which can only be used after removing the thicker oxide layer, and electron beam irradiation is line-of-sight processing, and part of the curved surface of the acetabular cup cannot be irradiated (O.K.Muratoglua, D.O.O'Connora, CR Bragdon, Gradient crosslinking of UHMWPE using irradiation in molten state for totaljoint arthritis.Biomaterials, 2002, 23:717-724); ion implantation can improve the surface crosslinking of UHMWPE while maintaining the overall original performance of UHMWPE degree, hardness and wear resistance, but the injection layer is too thin to be used for a long time

Method used

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  • Nano-granules reinforced ultra-high molecular weight polyethylene artificial joint material and production method thereof
  • Nano-granules reinforced ultra-high molecular weight polyethylene artificial joint material and production method thereof
  • Nano-granules reinforced ultra-high molecular weight polyethylene artificial joint material and production method thereof

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Embodiment 1

[0023] Embodiment 1: select ultra-high molecular weight polyethylene powder for use, molecular weight is 3,000,000; Filling material is to use nanometer SiO 2 Powder (note: other nanoparticles with good biocompatibility are acceptable, such as metal and alloy particles), with a purity of 99% and an average particle size of 10nm.

[0024] The preparation process of the composite material is as follows:

[0025] (1) be that 100m sieve is screened to high molecular weight polyethylene powder with aperture;

[0026] (2) Use 1% KH-570 coupling agent to nano-SiO 2 Particle surface modification;

[0027] (3) the mass fraction is respectively 1%, 3%, 6%, 10% nano-SiO 2 The powder and the UHMWPE powder are wet-mixed in an ethanol solution in a ball mill, the speed of the ball mill is 200 rpm, and each mixing process is clockwise and counterclockwise for 30 minutes;

[0028] (4) Ultrasonic dispersion is carried out for 10 minutes to the powder after wet mixing, and then dried in a d...

Embodiment 2

[0033] Embodiment 2: select ultra-high molecular weight polyethylene powder for use, and molecular weight is 5,000,000; Filling material is tetragonal nanometer ZrO 2 Powder with a purity of 99.9% and an average particle size of 40nm.

[0034] The preparation process of the composite material is as follows:

[0035] (1) be that 100m sieve is screened to high molecular weight polyethylene powder with aperture;

[0036] (2) Use 1.5% KH-570 coupling agent to nanometer ZrO 2 Particle surface modification;

[0037] (3) the mass fraction is respectively 1%, 2%, 3%, 5% nanometer ZrO 2 The powder and the UHMWPE powder are wet-mixed in an ethanol solution in a ball mill, the speed of the ball mill is 200 rpm, and each mixing process is clockwise and counterclockwise for 30 minutes;

[0038] (4) Ultrasonic dispersion is carried out for 10 minutes to the powder after wet mixing, and then dried in a drying oven;

[0039] (5) Add the dried mixed powder into the mold, hot-press molding...

Embodiment 3

[0043] Embodiment 3: Select ultra-high molecular weight polyethylene powder, molecular weight is 5,000,000; Filling material is α crystal form nanometer Al 2 o 3 Powder with a purity of 99.9% and an average particle size of 80nm.

[0044] The preparation process of the composite material is as follows:

[0045] (1) be that 100m sieve is screened to high molecular weight polyethylene powder with aperture;

[0046](2) Use 3% KH-570 coupling agent to nanometer Al 2 o 3 Particle surface modification;

[0047] (3) the mass fraction is respectively 1%, 2%, 3%, 5%, 10% nanometer Al 2 o 3 The powder and the UHMWPE powder are wet-mixed in an ethanol solution in a ball mill, the speed of the ball mill is 200 rpm, and each mixing process is clockwise and counterclockwise for 30 minutes;

[0048] (4) Ultrasonic disperse the powder after wet mixing for 10 minutes, and then dry in a drying oven;

[0049] (5) Add the dried mixed powder into the mold, hot-press molding at a pressure o...

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Abstract

The invention discloses a nanoparticle reinforced ultra high molecular weight polyethylene artificial joint material and a preparation method thereof. The nanoparticle reinforced ultra high molecular weight polyethylene artificial joint material takes nanoparticles which are filled in the ultra high molecular weight polyethylene as cross-linking points, thereby forming a polymer composite material with a network cross-linking structure. The method comprises the following steps: ultra high molecular weight polyethylene powder is subdivided and screened; ethanol solution containing a coupling agent is used for modifying the nanoparticles; the nanoparticles are fully mixed with the ultra high molecular weight polyethylene powder; the powder after the mixing is dispersed; the mixed powder is added in a mold, and the block composite material is prepared by hot-pressing forming. The filling amount of nanoparticles in the nanoparticle / UHMWPE composite material is low, which is less than 10 percent by weight; the wear rate of the composite material is decreased to one half to one fifth of pure UHMWPE, the friction coefficient is decreased to one half to one fourth of the pure UHMWPE, and the experimental results on a knee joint wear test machine particularly prove that the wear resistance thereof is significantly improved.

Description

technical field [0001] The invention belongs to a material for implant devices, which is suitable for artificial joint friction bearing material—nano particle reinforced ultra-high molecular weight polyethylene artificial joint material and its preparation method. Background technique [0002] Ultra-high molecular weight polyethylene (UHMWPE) has good chemical stability, impact resistance and friction and wear properties. It has been used as a joint friction bearing material for more than 40 years. Debris is the main factor leading to aseptic loosening and late failure of artificial joints. Irradiation can improve the degree of crosslinking, hardness and wear resistance of UHMWPE. Tests have shown that γ-ray irradiation crosslinking can increase the wear resistance of UHMWPE on a hip simulator by more than 90% (SM Kurtz, OK Muratoglu, M Evans, AA Edidin. Advances in the processing, sterilization, and crosslinking of ultra -high molecular weightpolyethylene for total joint ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/44A61L27/16A61L27/02A61F2/30
Inventor 熊党生汪婧雅
Owner NANJING UNIV OF SCI & TECH
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