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Preparation method of ofloxacin sustained-release capsules

A technology of ofloxacin and sustained-release capsules is applied in the field of ofloxacin sustained-release capsule preparations to achieve the effects of slowing absorption, smoothing the shape of the time curve, and avoiding sudden release

Inactive Publication Date: 2009-07-08
西安远大德天药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The technical problem to be solved by the present invention is to overcome the shortcomings of the above-mentioned ofloxacin sustained-release capsules, and provide a kind of gastrointestinal tract stimulation effect, good coating effect, particles are not easy to fall off, coating liquid is easy to adhere, and the environment in the production process Preparation method of ofloxacin sustained-release capsules with little pollution

Method used

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  • Preparation method of ofloxacin sustained-release capsules
  • Preparation method of ofloxacin sustained-release capsules
  • Preparation method of ofloxacin sustained-release capsules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Taking the production of 1000 ofloxacin sustained-release capsule products as an example, its preparation method is as follows:

[0049] 1. Ingredients

[0050] Weigh the medicinal active ingredients and auxiliary materials according to the following mass ratios:

[0051] Ofloxacin 200g

[0052] Microcrystalline Cellulose 42.43g

[0053] Lactose 28.28g

[0054] Citric acid 15g

[0055] The weight proportion of the used raw materials of above-mentioned medicine is:

[0056] Ofloxacin 70.00%

[0057] Microcrystalline Cellulose 14.85%

[0058] Lactose 9.90%

[0059] Citric acid 5.25%

[0060] 2. mix

[0061] Grind ofloxacin through a 120-mesh sieve, crush lactose through an 80-mesh sieve, and citric acid through an 80-mesh sieve, weigh ciprofloxacin hydrochloride, lactose, and citric acid according to the mass ratio and mix them uniformly with a mixer to prepare into a mixture.

[0062] 3. Prepare vegetarian pills

[0063] Grind the microcrystalline cellulose t...

Embodiment 2

[0085] Taking the production of 1000 ofloxacin sustained-release capsule products as an example, its preparation method is as follows:

[0086] In batching step 1 of the present invention, the consumption of used ofloxacin, the consumption of auxiliary material are identical with embodiment 1.

[0087] In step 3 of preparing the plain pill of the present invention, the polishing time is 2 minutes, and other steps are the same as in Example 1.

[0088] In the coating step 4 of the present invention, when the coating amount of Suwan 1000g is 4.0%, the coating solution is made from the raw materials of the following mass ratio:

[0089] Aqueous dispersion of ethyl acrylate-methyl methacrylate copolymer 10.98g

[0090] Aqueous dispersion of methacrylic acid-ethyl acrylate copolymer 87.50g

[0091] Talc powder 5.49g

[0092] Polyethylene glycol 6000 5.49g

[0093] Sodium Lauryl Sulfate 0.55g

[0094] Water 449.05mL

[0095] The mass percent of above-mentioned coating solution...

Embodiment 3

[0104] Taking the production of 1000 ofloxacin sustained-release capsule products as an example, its preparation method is as follows:

[0105] In batching step 1 of the present invention, the consumption of used ofloxacin, the consumption of auxiliary material are identical with embodiment 1.

[0106] In step 3 of preparing the plain pill of the present invention, the polishing time is 8 minutes, and other steps are the same as in Example 1.

[0107] In the coating step 4 of the present invention, when the coating amount of Suwan 1000g is 4.0%, the coating solution is made from the raw materials of the following mass ratio:

[0108] Aqueous dispersion of ethyl acrylate-methyl methacrylate copolymer 22.36g

[0109] Aqueous dispersion of methacrylic acid-ethyl acrylate copolymer 175.70g

[0110] Talc powder 10.98g

[0111] Polyethylene glycol 6000 10.98g

[0112] Sodium Lauryl Sulfate 0.11g

[0113] Water 328.93mL

[0114] The mass percent of above-mentioned coating solut...

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Abstract

A method for preparing ofloxacin sustained-release capsules comprises steps of preparing materials, mixing, preparing pills, coating and filling into capsules. In the coating process, granules do not easily fall off and coating liquid is easily attached so that sustained-release function can be achieved and medicine can be relatively well released. By employing the ofloxacin sustained-release capsules prepared by the method, experiments show that, absorption in vivo is slowed down, shape of a blood concentration-time curve becomes relatively flat, sudden release is avoided, and the ofloxacin sustained-release capsules can keep blood concentration remarkably superior to the conventional ofloxacin tablets and has sustained-release function. The ofloxacin sustained-release capsules are used for treating adult sensitive strain-induced urinary tract infections and genitourinary tract infections comprising simple urinary tract infections, complex urinary tract infections, bacterial prostatitis, gonococcal urethritis, cervicitis, intrauterine infections, appendagitis, etc.

Description

technical field [0001] The invention belongs to the technical field of medical preparations containing inorganic active ingredients, and in particular relates to ofloxacin sustained-release capsule preparations. Background technique [0002] Ofloxacin sustained-release capsules are suitable for adults with urinary tract infections and genitourinary tract infections caused by sensitive strains, including simple and complicated urinary tract infections, bacterial prostatitis, gonococcal urethritis, cervicitis, intrauterine In the treatment of infection and adnexitis, small doses have little effect on the gastrointestinal tract, but large doses may cause digestive tract discomfort, nausea, and vomiting. The existing coating materials use polymer materials to coat the compound drug pellets, which can control the release of drugs. Ethyl cellulose is a commonly used coating material, but when coated with organic solvents, the static electricity is serious and the pollution is rela...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/5383A61K9/58A61J3/07A61P31/04
Inventor 唐星黄惠锋任延成宋莹王亚轩
Owner 西安远大德天药业股份有限公司
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