Preparation method of ofloxacin sustained-release capsules

A technology of ofloxacin and sustained-release capsules is applied in the field of ofloxacin sustained-release capsule preparations to achieve the effects of slowing absorption, smoothing the shape of the time curve, and avoiding sudden release
CN101474187AInactive Publication Date: 2009-07-08西安远大德天药业股份有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
西安远大德天药业股份有限公司
Publication Date
2009-07-08
Estimated Expiration
Not applicable · inactive patent

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Abstract

A method for preparing ofloxacin sustained-release capsules comprises steps of preparing materials, mixing, preparing pills, coating and filling into capsules. In the coating process, granules do not easily fall off and coating liquid is easily attached so that sustained-release function can be achieved and medicine can be relatively well released. By employing the ofloxacin sustained-release capsules prepared by the method, experiments show that, absorption in vivo is slowed down, shape of a blood concentration-time curve becomes relatively flat, sudden release is avoided, and the ofloxacin sustained-release capsules can keep blood concentration remarkably superior to the conventional ofloxacin tablets and has sustained-release function. The ofloxacin sustained-release capsules are used for treating adult sensitive strain-induced urinary tract infections and genitourinary tract infections comprising simple urinary tract infections, complex urinary tract infections, bacterial prostatitis, gonococcal urethritis, cervicitis, intrauterine infections, appendagitis, etc.
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Description

technical field

[0001] The invention belongs to the technical field of medical preparations containing inorganic active ingredients, and in particular relates to ofloxacin sustained-release capsule preparations. Background technique

[0002] Ofloxacin sustained-release capsules are suitable for adults with urinary tract infections and genitourinary tract infections caused by sensitive strains, including simple and complicated urinary tract infections, bacterial prostatitis, gonococcal urethritis, cervicitis, intrauterine In the treatment of infection and adnexitis, small doses have little effect on the gastrointestinal tract, but large doses may cause digestive tract discomfort, nausea, and vomiting. The existing coating materials use polymer materials to coat the compound drug pellets, which can control the release of drugs. Ethyl cellulose is a commonly used coating material, but when coated with organic solvents, the static electricity is serious and the pollution is rela...

Claims

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