Polysaccharide/calcium orthophosphate composite bone cement and preparation method thereof

Abstract

The invention discloses a polysaccharide / autosolidification calcium phosphate composite bone cement composition, which comprises the following components in percentage by weight: 10 to 95 weight percent of autosolidification calcium phosphate bone cement and 5 to 90 weight percent of polysaccharide. The bone cement composition can obtain bone cement with high strength, good toughness, strong plasticity, quick solidification, and good biocompatibility and degradability, thereby overcoming the defects of inadequate toughness and slow degradation in human bodies existing in the prior calcium phosphate bone cement materials and the defects existing in a plurality of enhancement methods in the prior art, and better meeting the requirement of operation use.

Description

technical field [0001] The invention belongs to the field of medical biomaterials and relates to a novel organic / inorganic composite material used for filling or injecting to repair human hard tissue defects. Background technique [0002] The repair and treatment of bone defects has long been a thorny problem for surgeons. Scientists from all over the world have been devoting themselves to the research and development of ideal bone repair materials. In the mid-1980s, Brown and Chow in the United States invented a self-curing bioactive bone defect repair material—calcium phosphate cement (Calcium phosphate cement, CPC), which can be hydrated and solidified by itself in the physiological environment of the human body. It is finally transformed into hydroxyapatite (HA) which is similar to the composition of human bone, and the heat release is less during the curing process, and it can be shaped arbitrarily according to the shape of the bone defect, which has attracted great att...

AI Technical Summary

Problems solved by technology

However, the disadvantage of adding fiber molecules to the calcium phosphate bone cement mentioned above is that because there are interface problems between the inorganic cement and the polymer fibers, it generally only has a reinforcing effect when the amount of fibers added is very small, while toughening The effect is often not obvious; at the same time, since most of these added fibers do not degrade, it is impossible to take into account the mechanical properties and degradation properties of the composite material at the same time

The disadvantage of the above-mentioned bone cement is that the added components degrade slowly or do not degrade, which will affect the formation of new bone when used for bone repair

Calcium phosphate bone cement is an important bioactive bone repair material. Although its related research progresses rapidly, there are still some problems to be solved, such as insufficient strength and slow curing speed.

Most of the existing commonly used reinforcement methods introduce fibers or other external components. The interfacial bonding between the reinforcement and the matrix is ​​the key to the research of this type of composite material; most fibers and other external components can only be reinforced when the amount of addition is small. effect, it is difficult to simultaneously improve strength and toughness

At the same time, because many external components do not degrade or degrade slowly, it is more difficult to balance the mechanical properties and degradation properties of calcium phosphate bone cement

[0010] Therefore, there is an urgent need for a calcium phosphate composite bone cement and a preparation method thereof in this area. The bone cement has high strength, good toughness, strong plasticity, fast curing, good biocompatibility and degradability, thereby overcoming the existing calcium phosphate The lack of toughness of bone cement materials, the defects of slow degradation in the human body, and the defects of several reinforcement methods can better meet the requirements of surgical use