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Method for preparing protamine and dextran sulfate sodium microcapsule

A technology of dextran sodium sulfate and protamine, which is applied in the direction of microcapsule preparation and microsphere preparation, can solve the problems of polyelectrolyte non-degradability or template toxicity residue, harsh preparation conditions, application restrictions, etc., and is easy to promote and application, easy to obtain, cheap effect

Inactive Publication Date: 2009-09-16
NINGBO UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although many polyelectrolytes with new functions can be used to prepare microcapsules and obtain relatively perfect structures, their applications are limited due to factors such as harsh preparation conditions, non-degradability of polyelectrolytes, or residual template toxicity.

Method used

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  • Method for preparing protamine and dextran sulfate sodium microcapsule
  • Method for preparing protamine and dextran sulfate sodium microcapsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] (1), first mix the calcium chloride solution of 33.3 g / liter and the sodium polystyrene sulfonate solution of 1 g / liter, wherein the mass ratio of calcium chloride and sodium polystyrene sulfonate is 17:1, and then Under stirring at a rotating speed of 600rpm, the sodium carbonate solution having the same molarity and volume as the calcium chloride was quickly added to the calcium chloride solution, and reacted at a constant temperature of 10° C. for 6 minutes to obtain calcium carbonate microspheres. The calcium carbonate microspheres were centrifuged and washed for later use. The obtained microspheres are regular spherical, such as figure 1 Shown is the morphology of calcium carbonate microspheres, as can be seen from the figure, the calcium carbonate microspheres have good monodispersity, and the particle size is about 4 microns.

[0023] (2) Add calcium carbonate microspheres to 2 g / L protamine sulfate aqueous solution containing 23.4 g / L sodium chloride, disperse ...

Embodiment 2

[0028] (1), first mix the calcium chloride solution of 33.3 g / liter and the sodium polystyrene sulfonate solution of 1 g / liter, wherein the mass ratio of calcium chloride and sodium polystyrene sulfonate is 50:1, and then Under stirring at a rotating speed of 600rpm, the sodium carbonate solution having the same molarity and volume as the calcium chloride was quickly added to the calcium chloride solution, and reacted at a constant temperature of 50° C. for 6 minutes to obtain calcium carbonate microspheres. The calcium carbonate microspheres were centrifuged and washed for later use. The obtained microspheres are regular spherical, and the particle size is about 4.5 microns.

[0029] (2) Add calcium carbonate microspheres to 2 g / L protamine sulfate aqueous solution containing 23.4 g / L sodium chloride, disperse evenly, then place on a shaker to vibrate for 20-30 minutes, centrifuge, and drain The supernatant was dispersed with deionized water, then centrifuged, and washed wit...

Embodiment 3

[0034] (1), first mix the calcium chloride solution of 33.3 g / liter and the sodium polystyrene sulfonate solution of 1 g / liter, wherein the mass ratio of calcium chloride and sodium polystyrene sulfonate is 100:1, and then Under stirring at a rotating speed of 600rpm, the sodium carbonate solution having the same molarity and volume as the calcium chloride was quickly added to the calcium chloride solution, and reacted at a constant temperature of 80° C. for 6 minutes to obtain calcium carbonate microspheres. The calcium carbonate microspheres were centrifuged and washed for later use. The obtained microspheres are regular spherical, and the particle size is about 5 microns.

[0035] (2) Add calcium carbonate microspheres to 2 g / L protamine sulfate aqueous solution containing 23.4 g / L sodium chloride, disperse evenly, then place on a shaker to vibrate for 20-30 minutes, centrifuge, and drain The supernatant was dispersed with deionized water, then centrifuged, and washed with...

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Abstract

The invention relates to a method for preparing the protamine and dextran sulfate sodium microcapsule, comprising the following steps: reacting calcium chloride, sodium carbonate, sodium polystyrene sulfonate or polyallylamine hydrochloride, cetyl trimethyl ammonium bromide, PEO20-PPO70-PEO20 triblock copolymer, polydiallyldimethylamine chloride solution with stirring at the temperature of 10 to 80 DEG C to obtain the calcium carbonate microsphere; fully mixing the obtained calcium carbonate microsphere with the protamine water solution, adsorbing the protamine, removing the protamine not to be adsorbed, fully mixing the calcium carbonate microsphere with the protamine withdextran sulfate sodium containing inorganic salt to adsorb dextran sulfate sodium, removing the dextran sulfate sodium not to be adsorbed; alternately adsorbing to obtain the microcapsule with the protamine and dextran sulfate sodium multilayer membrane core-shell structure; dissolving calcium carbonate in ethylenediaminetetraacetic acid sodiumsalt to obtain the protamine and dextran sulfate sodium microcapsule.

Description

technical field [0001] The invention relates to a method for preparing microcapsules, in particular to a method for preparing microcapsules by electrostatic self-assembly. Background technique [0002] In 1997, G. Decher et al. ("Toward Layered Polymeric Multicomposites. Science", 1997, 277: 1232-1237) discovered that polymer chains with positive and negative charges, that is, polyelectrolytes, can be assembled alternately on the surface bands due to electrostatic forces. Charged flat plate, this technique is called electrostatic self-assembly (LbL), which opened the prelude to the study of layered assembled thin films, and later applied this method on the surface of microspheres, and then removed the template particles to obtain the polymer Electrolyte microcapsules. This method has the characteristics of simple preparation process, adjustable number of polyelectrolyte layers assembled on the particle surface, and functional modification of the polyelectrolyte constituting...

Claims

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Application Information

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IPC IPC(8): B01J13/02
Inventor 金谊邵琼芳陈斌刘新文王家荣房江华
Owner NINGBO UNIVERSITY OF TECHNOLOGY
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