Method for preparing protamine and dextran sulfate sodium microcapsule

A technology of dextran sodium sulfate and protamine, which is applied in the direction of microcapsule preparation and microsphere preparation, can solve the problems of polyelectrolyte non-degradability or template toxicity residue, harsh preparation conditions, application restrictions, etc., and is easy to promote and application, easy to obtain, cheap effect
CN101530767AInactive Publication Date: 2009-09-16NINGBO UNIVERSITY OF TECHNOLOGY
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
NINGBO UNIVERSITY OF TECHNOLOGY
Publication Date
2009-09-16
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a method for preparing the protamine and dextran sulfate sodium microcapsule, comprising the following steps: reacting calcium chloride, sodium carbonate, sodium polystyrene sulfonate or polyallylamine hydrochloride, cetyl trimethyl ammonium bromide, PEO20-PPO70-PEO20 triblock copolymer, polydiallyldimethylamine chloride solution with stirring at the temperature of 10 to 80 DEG C to obtain the calcium carbonate microsphere; fully mixing the obtained calcium carbonate microsphere with the protamine water solution, adsorbing the protamine, removing the protamine not to be adsorbed, fully mixing the calcium carbonate microsphere with the protamine withdextran sulfate sodium containing inorganic salt to adsorb dextran sulfate sodium, removing the dextran sulfate sodium not to be adsorbed; alternately adsorbing to obtain the microcapsule with the protamine and dextran sulfate sodium multilayer membrane core-shell structure; dissolving calcium carbonate in ethylenediaminetetraacetic acid sodiumsalt to obtain the protamine and dextran sulfate sodium microcapsule.
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Description

technical field

[0001] The invention relates to a method for preparing microcapsules, in particular to a method for preparing microcapsules by electrostatic self-assembly. Background technique

[0002] In 1997, G. Decher et al. ("Toward Layered Polymeric Multicomposites. Science", 1997, 277: 1232-1237) discovered that polymer chains with positive and negative charges, that is, polyelectrolytes, can be assembled alternately on the surface bands due to electrostatic forces. Charged flat plate, this technique is called electrostatic self-assembly (LbL), which opened the prelude to the study of layered assembled thin films, and later applied this method on the surface of microspheres, and then removed the template particles to obtain the polymer Electrolyte microcapsules. This method has the characteristics of simple preparation process, adjustable number of polyelectrolyte layers assembled on the particle surface, and functional modification of the polyelectrolyte constituting...

Claims

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