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Rehabilitation new dispersing tablet and preparation method thereof

A dispersible tablet and weight percentage technology, which is applied in the digestive system, pill delivery, medical raw materials derived from arthropods, etc., can solve the problems of unfavorable transportation, easy deterioration, easy precipitation, etc., and achieve rapid drug dissolution, low production cost, Easy transportation and stable effect

Inactive Publication Date: 2009-10-28
EASTERN LIAONING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The present invention is just to solve the shortcomings of traditional dosage forms that are easy to deteriorate, easy to precipitate, and not conducive to transportation, improve the curative effect, reduce side effects, combine the advantages of tablets and liquid preparations, improve product quality, and ensure product efficacy. Based on the selection principle of "three small and five convenient", the Kangfuxin dispersible tablet that can be rapidly disintegrated in contact with water to form a uniform suspension and its preparation method were invented

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Periplaneta americana 2000g

[0033] Microcrystalline Cellulose (MCC) 542g

[0034] Cross-linked polyvinylpyrrolidone (PVPP) 117g

[0035] Sodium Carboxymethyl Starch (CMS-Na) 17g

[0036] Micronized silica gel 4g

[0037] Magnesium Stearate 4g

[0038] 75% ethanol appropriate amount

[0039] Preparation method: take Periplaneta americana and crush it into coarse powder, use 3 times the amount of 70% alcohol to reflux extract 3 times at 64°C, combine the extracts, filter, recover ethanol, concentrate to a thick paste with a relative density of 1.35 (70°C), Vacuum-dried at 60°C, pulverized, and passed through a 100-mesh sieve to obtain dry extract powder, which was prepared by fully mixing dry extract powder, microcrystalline cellulose, cross-linked polyvinylpyrrolidone and sodium starch glycolate, and adding appropriate amount of 75% ethanol Soft materials are granulated with a 20-mesh sieve, dried at 60°C, granulated with a 20-mesh sieve, mixed with magnesium stea...

Embodiment 2

[0042] Periplaneta americana 2000g

[0043] Lactose 240g

[0044] 480g pregelatinized starch

[0045] Cross-linked polyvinylpyrrolidone 120g

[0046] Proper amount of ethanol

[0047] Magnesium Stearate 10g

[0048] Preparation method: take Periplaneta americana and crush it into coarse powder, use 3 times the amount of 70% ethanol to reflux extract at 64°C for 3 times, combine the extracts, filter, recover ethanol, concentrate to a thick paste with a relative density of 1.35 (70°C), Vacuum-dried at 60°C, crushed, and passed through a 100-mesh sieve to obtain dry extract powder, fully mix dry extract powder, lactose, pregelatinized starch, and cross-linked polyvinylpyrrolidone, and add appropriate amount of ethanol to make a soft material, 20 mesh Sieve to granulate, dry at 60°C, sieve through a 20-mesh sieve for granulation, add magnesium stearate, mix evenly, and press into tablets to obtain Fuxin Dispersible Tablets. The obtained dispersible tablets have the following ...

Embodiment 3

[0051] Periplaneta americana 2000g

[0052] Lactose 150g

[0053] Pregelatinized starch 206g

[0054] Microcrystalline Cellulose 537g

[0055] Low-substituted hydroxypropyl cellulose 79g

[0056] 75% ethanol appropriate amount

[0057] Magnesium stearate 8g

[0058]Preparation method: take Periplaneta americana and crush it into coarse powder, use 3 times the amount of 70% ethanol to reflux extract at 64°C for 3 times, combine the extracts, filter, recover ethanol, concentrate to a thick paste with a relative density of 1.35 (70°C), Vacuum-dried at 60°C, pulverized, and passed through a 100-mesh sieve to obtain dry extract powder, fully mix dry extract powder, lactose, pregelatinized starch and low-substituted hydroxypropyl cellulose, add appropriate amount of ethanol to make a soft material, Granulate with a 20-mesh sieve, dry at 60°C, granulate with a 20-mesh sieve, add magnesium stearate, mix evenly, and press into tablets to obtain Fuxin Dispersible Tablets. The obta...

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Abstract

The invention discloses a rehabilitation new dispersing tablet used for treating digestive system diseases and a preparation method thereof. The rehabilitation new dispersing tablet is prepared from a major material, namely 10 to 55 weight percent of rehabilitation new dry extract powder, and accessories comprising a disintegrant, a filling agent, a wetting agent and a lubricant through granulation and tabletting by a wet method, wherein the disintegrant can be added internally or externally or internally and externally. Compared with the prior solution, the rehabilitation new dispersing tablet has the advantages of good dispersing state, short disintegration time, quick medicament dissolution, convenient taking, low production cost, no need of special equipment, easy mass production, convenient carrying and transportation, stability and the like.

Description

technical field [0001] The invention relates to a traditional Chinese medicine dispersible tablet for treating peptic ulcer and a preparation method thereof Background technique [0002] Fufuxin is an extract separated and refined from the extract of Periplaneta americana. Its complex composition contains 18 kinds of amino acids, of which alanine is the most, and it also contains animal oil, protein, polyols and peptide active substances. Kangfuxin oral administration has obvious protective effect on pyloric ligation gastric ulcer and absolute ethanol gastric ulcer, can significantly reduce gastric juice secretion, total acid excretion and pepsin excretion, has curative effect on peptic ulcer, and can effectively prevent chronic Colitis, duodenitis, etc. Kangfuxin also has antioxidant effect, which can increase the activity of lymphocytes and serum lysozyme, increase the SOD value in the body, and regulate the physiological balance of the body. Rehabilitation has been used...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/64A61K9/20A61P1/04
Inventor 宋红光
Owner EASTERN LIAONING UNIV
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