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Method for preparing hydrophilic molecular imprinting microsphere by using ionic liquid as novel functional monomer by suspension method

A technology of molecularly imprinted microspheres and functional monomers, applied in chemical instruments and methods, and other chemical processes, can solve the problems of low imprinting efficiency, limited interaction types of related groups, and weak hydrophilicity, etc., to achieve selective High performance, strong rigidity, good hydrophilic effect

Inactive Publication Date: 2010-02-17
NANCHANG HANGKONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing hydrophilic monomers still have defects such as weak hydrophilicity, the type of interaction of related groups is limited to hydrogen bonding, and low imprinting efficiency.

Method used

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  • Method for preparing hydrophilic molecular imprinting microsphere by using ionic liquid as novel functional monomer by suspension method
  • Method for preparing hydrophilic molecular imprinting microsphere by using ionic liquid as novel functional monomer by suspension method
  • Method for preparing hydrophilic molecular imprinting microsphere by using ionic liquid as novel functional monomer by suspension method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Put 6.0000g of PVA124 and 150mL of water into a 250mL four-neck flask, stir to dissolve and heat to 85-90°C. Dissolve 0.6880 g of α-methacrylic acid functional monomer and theophylline in 20 mL of water, and add them into the four-neck bottle. Then 13.5200g TRIM, 0.2000g AIBN and 10mL of toluene were mixed and stirred, and when the AIBN was dissolved, they were added to the four-necked flask, and N 2 Seal it after 5 minutes, and stir at constant temperature (75°C) and constant speed (365rpm) for 8 hours to complete the reaction.

[0030] Elution process

[0031] The polymer obtained by the reaction was first washed twice with 100mL acetone and ethanol; (甲醇) :V (乙酸) = 9:1 solution elution, until the caffeine in the eluent can not detect the imprinted molecules in the high performance liquid chromatography, and then repeatedly washed with deionized water until neutral, and finally the eluted polymer was air-dried at room temperature Instant MIPs. When caffeine was u...

Embodiment 2

[0033] Put 6.0000g of PVA124 and 150mL of water into a 250mL four-neck flask, stir to dissolve and heat to 85-90°C. The synthesized 2.0000 ionic liquid functional monomer and 0.3883g of caffeine were dissolved in 20mL of water and added to the four-necked bottle. Then 13.5200g TRIM, 0.2000g AIBN and 10mL of toluene were mixed and stirred, and when the AIBN was dissolved, they were added to the four-necked flask, and N 2 Seal it after 5 minutes, and stir at constant temperature (75°C) and constant speed (365rpm) for 8 hours to complete the reaction. Such as figure 1 As shown, the abscissa represents the initial solubility of caffeine, and the ordinate represents the temperature, and the temperature is also rising with the increase of the caffeine solubility.

[0034] The elution process is the same as above

[0035] When theophylline was used as a competitive substrate, the separation factor of the obtained polymer in water environment was 1.91, and when cyromazine was used...

Embodiment 3

[0037] Put 6.0000g of PVA124 and 150mL of water into a 250mL four-neck flask, stir to dissolve and heat to 85-90°C. Dissolve 2.0000g of the synthesized new functional monomer and 0.3603g of theophylline in 20mL of water, and add them to the four-necked bottle. Then 13.5200g TRIM, 0.2000g AIBN and 10mL of toluene were mixed and stirred, and when the AIBN was dissolved, they were added to the four-necked flask, and N 2 Seal it after 5 minutes, and stir at constant temperature (75°C) and constant speed (365rpm) for 8 hours to complete the reaction.

[0038] The elution process is the same as above

[0039] When caffeine was used as a competitive substrate, the separation factor of the obtained polymer in aqueous environment was 1.41, and when cyromazine was used as a competitive substrate, the separation factor was 6.51. The microspheres of the obtained polymer were on average 50 μm.

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Abstract

The invention relates to a method for preparing hydrophilic molecular imprinting microsphere by using ionic liquid as a novel functional monomer by a suspension method. The method is characterized bycomprising the following steps: (1) synthesizing iminazole type ionic liquid with double-bond carboxylic acid by using alkyl imidazole and brominated trialkyl crylic acid; (2) adding a dispersing agent into water and stirring the water until the dispersing agent is fully dissolved; (3) carrying out self-assembly on template molecules and functional monomers; (4) mixing trimethylolpropane trimethacrylate, an initiating agent and a diluent; (5) mixing the three solutions, leading N2 to an obtained mixed solution and then sealing the mixed solution; (6) washing a polymer obtained by the reactionby an organic solvent; and (7) airing the polymer at normal temperature to obtain the hydrophilic molecular imprinting microsphere. The invention has the advantages that the synthesized molecular imprinting polymer has the characteristics of controllable size, strong rigidity, good hydrophilicity and high selectivity and is quite suitable for the enrichment, the separation and the analysis of analogs in foods, biological samples and aquatic environment samples.

Description

technical field [0001] The invention relates to a method for preparing hydrophilic molecularly imprinted microspheres by using ionic liquid as a novel functional monomer suspension method. Background technique [0002] In recent years, with the deepening of research on molecular imprinting technology and the expansion of application fields, the preparation technology and performance research of molecularly imprinted polymers (MIP) have been widely concerned and highly valued by scholars from all over the world. However, the preparation technology of MIP is mainly based on bulk polymerization, and the obtained product is in the form of lumps, which can be used after grinding and sieving to obtain particles of the required size. However, grinding will lead to the destruction of some binding groups, thereby reducing the performance of molecular recognition and selection, and the resulting particles are irregular in shape and poor in dispersibility. In addition, the product los...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/285B01J20/30
Inventor 罗旭彪占幼才涂新满颜流水罗胜联
Owner NANCHANG HANGKONG UNIVERSITY
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