Medicament for treating coronary disease and stenocardia and preparation method thereof

Abstract

The invention provides a medicament for treating coronary disease and stenocardia and a preparation method thereof. The method comprises the following steps: 1, putting 6 parts of hawthorn extract into a cavity of a granulator, adding 5 to 15 parts of hydroxypropyl beta cyclodextrin and 4 to 10 parts of calcium monohydrogen phosphate by weight into the cavity, stirring the mixture at high speed, injecting ethanol into the cavity, stirring the mixture once again, granulating the mixture and drying the granules; 2, putting 20 parts of pueraria flavonid and 2 parts of gypenosides by weight in a mixture, adding the mixture of 10 to 15 parts of pregelatinized starch and 0.7 to 1.4 parts of croscarmellose sodium in a material cavity of a one-step granulator, injecting hydroxypropyl beta cyclodextrin ethanol solution into the material cavity of the granulator, drying the materials for 1 hour after feed liquid is injected, and stabilizing the granules for later use; and 3, adding the granules into the mixture, adding 0.3 to 0.6 part of the croscarmellose sodium and 0.2 to 0.6 part of superfine silica powder into the mixture for mixing and tableting, coating the tablets with films or filling the tablets, and subpackaging the tablets. The medicament prepared by the method has remarkable curative effect and long quality guarantee period.

Description

technical field [0001] The invention relates to a medicine and a preparation method thereof, in particular to a medicine for treating coronary heart disease and angina pectoris and a preparation method thereof. Background technique [0002] Coronary heart disease and angina pectoris refer to clinical syndromes caused by coronary insufficiency, acute and temporary myocardial ischemia and hypoxia. The principle of treatment for coronary heart disease and angina pectoris is to improve the blood supply of the coronary arteries and reduce the oxygen consumption of the myocardium, while treating atherosclerosis. Therapeutic drugs are divided into three categories. [0003] Category 1: Nitrate preparations, the main function is to dilate coronary arteries, reduce resistance, increase blood flow in coronary circulation, reduce cardiac preload and myocardial oxygen demand, and relieve angina pectoris. Commonly used preparations are nitroglycerin, isoamyl nitrite, pentyl tetranitrat...

AI Technical Summary

Problems solved by technology

[0006] The above-mentioned chemical drugs can basically control the acute attack stage of the disease at present, and the effect is to relieve or reduce the attack of angina pectoris, but it cannot completely solve the problem of coronary artery stenosis and the problem of atherosclerosis in this disease.

Patent No.: ZL03134404.6; Invention Name: A drug for treating coronary heart disease and angina pectoris and its preparation method, disclosing a drug prescription composition of soft capsules for treating coronary heart disease and angina pectoris and its preparation method. At present, there are strict requirements on storage conditions (in the dark), and the disintegration time limit is exceeded before the expiration date. The content of the drug is easy to precipitate, and the liquid leakage is easy to occur, which affects the storage, absorption and curative effect of the drug, and seriously hinders the clinical practice. In addition, the production process of soft capsules is complicated, the quality is difficult to control, and the high material loss leads to low yield and high cost of finished products, which seriously hinders the clinical application of such products, making the advantages of prescription treatment unable to achieve economic advantages

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