Multi-arm star polyester/hyperbranched polyglycidyl ether and preparation method thereof

A technology of polyglycidyl ether and glycidyl ether, which is used in pharmaceutical formulations, medical preparations with non-active ingredients, and pharmaceutical sciences, etc., can solve problems such as organ damage, non-biodegradability, etc., and achieve a long sustained release time. , the effect of increasing the load

Inactive Publication Date: 2010-06-02
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the polymer provided by this invention is not biodegradable, and it may accumulate in different organs in the body when used as a drug carrier material, so as to cause organ damage or some unforeseen adverse consequences

Method used

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  • Multi-arm star polyester/hyperbranched polyglycidyl ether and preparation method thereof
  • Multi-arm star polyester/hyperbranched polyglycidyl ether and preparation method thereof
  • Multi-arm star polyester/hyperbranched polyglycidyl ether and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Mix 0.1 part of pentaerythritol core molecule with 30 parts of purified lactide, after vacuum drying, add 0.03 part of catalyst zinc powder to mix, use an oil pump to vacuumize and dry at room temperature for 10 hours, vacuum seal the tube at 110°C for 120 hours, cool Afterwards, the multi-arm star-shaped biodegradable polyester is obtained by the commonly used polyester purification method; 1 part of the multi-arm star-shaped biodegradable polyester obtained in the above steps is vacuum-dried and dissolved in 10 parts of dry dichloromethane In a solvent, add 0.1 part of sodium methoxide to react at a temperature of 50 °C in a dry atmosphere to obtain a macromolecular initiator, then add 0.01 part of glycidyl ether dropwise, react at a temperature of 0 °C for 48 hours, and purify it with a dialysis membrane with a pore size of 3000 after cooling. A multi-arm star polyester / hyperbranched polyglycidyl ether is obtained.

Embodiment 2

[0044] Mix 0.5 parts of trimethylolethane core molecules with 35 parts of purified ε-caprolactone, and after vacuum drying, add 0.01 parts of the catalyst stannous octoate to mix, vacuumize with an oil pump and dry at 60°C for 1 hour, vacuum The sealed tube was reacted at 100°C for 80 hours, and after cooling, the multi-armed star-shaped biodegradable polyester was obtained by the commonly used polyester purification method; after the 5 parts of the multi-armed star-shaped biodegradable polyester prepared in the above steps were vacuum-dried , dissolved in 25 parts of dry tetrahydrofuran solvent, in a dry atmosphere at a temperature of 130 ° C, add 5 parts of potassium methylate to react to obtain a macromolecular initiator, then add 10 parts of glycidyl ether dropwise, react at a temperature of 20 ° C for 30 hours, after cooling The multi-arm star polyester / hyperbranched polyglycidyl ether is obtained by purifying with a dialysis membrane with a pore size of 3000.

Embodiment 3

[0046] Mix 10 parts of polyester-64-hydroxy-1-carboxy-bismethylolpropionic acid core molecule with 100 parts of purified lactide, after vacuum drying, add 5 parts of catalyst zinc powder and mix, and use an oil pump to evacuate Dry at 100°C for 2 hours, vacuum-seal the tube and react at 180°C for 12 hours. After cooling, use the usual polyester purification method to obtain a multi-armed star-shaped biodegradable polyester; After the biodegradable polyester was vacuum-dried, it was dissolved in 500 parts of dry N, N-dimethylformamide and ethyl acetate solvent (3:2 mass ratio), and 3 parts of The macromolecular initiator was obtained by the reaction of potassium naphthalene, and then 0.4 parts of glycidyl ether was added dropwise, and reacted at a temperature of 30°C for 40 hours. After cooling, it was purified with a dialysis membrane with a pore size of 10,000 to obtain a multi-armed star-shaped polyester / hyperbranched polyglycidyl ether .

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Abstract

The invention discloses multi-arm star polyester / hyperbranched polyglycidyl ether which comprises biodegradable polyester and polyglycidyl ether, the composed molecular shape takes the shape of a star which comprises a core, a support arm and a hyperbranched part, wherein the core is a residual part after compounds containing at least three hydroxyls are reacted, the support arm is biodegradable polyester, the hyperbranched part is polyglycidyl ether and has a structural general formula as below, wherein R is hyperbranched polyglycidyl ether. The invention also discloses a preparation method of the multi-arm star polyester / hyperbranched polyglycidyl ether. The multi-arm star polyester / hyperbranched polyglycidyl ether not only has biodegradability, but also can satisfy the requirements of control release of different drugs, medical product materials and tissue engineering as the structure simultaneously contains a hydrophobic part and the hydrophilic hyperbranched part, especially a great deal of terminal hydroxyls reserved in the structure can also be bonded with other drugs and various ligands to form a multifunctional medicine carrier.

Description

technical field [0001] The invention belongs to the technical field of biodegradable polymer materials and their preparation, in particular to a biodegradable multi-arm star polyester / hyperbranched polyglycidyl ether and a preparation method thereof. The biodegradable multi-arm star polyester / hyperbranched polyglycidyl ether provided by the invention can be used as drug controlled release carrier material, medical polymer material and tissue engineering material. Background technique [0002] With the development of polymer structure design and synthesis technology, non-linear branched polymers, such as dendrimers, hyperbranched polymers, star polymers, etc. emerge in an endless stream, because these polymers have unique structures, various Compared with linear polymers, the properties are quite different and gradually come into people's field of vision. Among them, dendrimers and hyperbranched polymers refer to polymers with dendritic highly branched structures, while star...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G65/28C08G63/00A61K47/34A61L17/10A61L27/18A61L31/06
Inventor 陈元维罗祥林陈年操张翠
Owner SICHUAN UNIV
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