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Absorbable magnesium alloy bracket of inorganic and organic antiseptic biocompatible composite coating and preparation method thereof

A magnesium alloy stent, biocompatibility technology, applied in coating, anodizing, medical science and other directions, can solve the problem of no drug-loaded coating, fast degradation rate, etc., to improve surface biocompatibility, solve degradation The rate is too fast to solve the effect of excessive magnesium ion release concentration

Active Publication Date: 2014-04-09
中知在线股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the stent degrades too quickly in the body and has no drug-loaded coating

Method used

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  • Absorbable magnesium alloy bracket of inorganic and organic antiseptic biocompatible composite coating and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Magnesium alloy WE42 (mass fraction of Y3.7-4.3%, RE (Nd: 2.0-2.5%, HeavyE: balance): 2.4-4.4%, Zr> 0.4%, Shanxi Magnesium Industry Group) was carved into a stent by laser, Then put it in the mass concentration of 7% HCl, mass concentration of 8% FeCl 2 Ultrasonic treatment in the acid pickling solution for 30 minutes, then put it in a vacuum furnace for annealing treatment, raise the temperature to 1100°C at a rate of 3°C / min, hold it for 30 minutes, and then reduce it to 20 at a rate of 4°C / min After ℃, the ultrasonic cleaner with a power of 500W was ultrasonically cleaned in deionized water for 15 minutes and then dried. The organic-inorganic magnesium alloy composite coating on the surface of the cell experiment had good biocompatibility and the degradation products were non-toxic.

[0027] An inorganic anticorrosive coating is prepared on the dried magnesium alloy stent base. Using the method of micro-arc oxidation, the electrolyte composition is NaOH1-100g / L, Na 2 Si...

Embodiment 2

[0033] The experimental conditions and operation process are the same as in Example 1. In the process of preparing the micro-arc oxidation inorganic coating, the oxidation time is changed to 20-120min, and the oxidation current is changed to 0.01A, 0.05A, 0.1A, 0.2A, 0.4A , 0.6A, 0.8A, 1.0A, 1.2A, 1.4A, 1.6A, 2.0A, the organic-inorganic composite coating of magnesium alloy on the cell surface has good biocompatibility, and the degradation products are non-toxic.

[0034] The prepared stent was tested in artificial body fluid at 37°C. The results showed that the corrosion resistance of the inorganic-organic composite coated magnesium alloy stent prepared by PLLA sealing was much higher than that of the unsealed inorganic coated magnesium alloy stent. The corrosion resistance of magnesium alloy can be changed by changing the current parameters. The corrosion resistance of the micro-arc oxidation current density of 0.5A is 30 times that of the magnesium alloy substrate. The polymer c...

Embodiment 3

[0036] The experimental conditions and operation process are the same as in Example 1, except that the micro-arc oxidation time is changed to 20-120min, and the oxidation current density is 0.01-2.0A\cm 2 , Similar to Examples 1 and 2, except for the change: In the process of preparing the organic PLLA sealing coating, the molecular weight of the PLLA is changed, and the biocompatibility of the magnesium alloy organic-inorganic composite coating on the cell surface is good, and the degradation products are non-toxic.

[0037] The prepared stent was tested in artificial body fluid at 37°C. The results showed that the degradation cycle of PLLA-sealed magnesium alloys with different molecular weights was different. The polymer coating was degraded within 150-360 days, and the metal stent was degraded within 240-420 days. .

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Abstract

The invention relates to an absorbable magnesium alloy bracket of an inorganic and organic antiseptic biocompatible composite coating and a preparation method thereof. The absorbable magnesium alloy bracket of the inorganic and organic antiseptic biocompatible composite coating comprises a magnesium alloy bracket backbone and a composite coating. The composite coating consists of an inorganic antiseptic coating, a compact organic hole sealing coating, a drug releasing coating and a drug slow release coating; the surface layer of the absorbable magnesium alloy bracket backbone is an inorganic porous antiseptic coating, the compact organic hole sealing coating is arranged outside the inorganic antiseptic coating, the drug releasing coating is arranged outside the compact organic coating, and the drug slow release coating is arranged outside the drug releasing coating. The invention effectively improves the corrosion resistance of the magnesium alloy bracket backbone and controls releasing rate of magnesium ions; meanwhile, the organic membrane layer improves the surface biocompatibility; the degraded products have no side effect, can be absorbed by human bodies, and have good biocompatibility and blood compatibility; and the drug releasing coating can reduce burst release of drug and ensure sustained slow release of drug.

Description

Technical field [0001] The invention relates to a magnesium alloy stent surface modification technology, in particular to an absorbable magnesium alloy stent with an inorganic organic anticorrosive and biocompatible composite coating and a preparation method thereof. Background technique [0002] In 1964, Dotter et al. proposed the concept of percutaneous transluminal angioplasty, and planned to use silicone rubber or plastic to support blood vessels to keep blood flowing in the blood vessels. In 1969, they used metal rings as vascular stents in animals for the first time. Sigwart successfully performed the first coronary artery stent operation in 1987. After that, cardiovascular stents were widely accepted as the second milestone in the history of interventional treatment of coronary heart disease. By the beginning of the 21st century, the clinical application of drug-eluting stents represented by Cypher and TAXUS was hailed as the third milestone. [0003] Coronary stent placem...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/10A61L31/08A61L31/02A61L31/16A61L31/14C25D11/30
Inventor 许鑫华逯平
Owner 中知在线股份有限公司
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