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Production method of basement for enhancing raman scattering of molecule

A Raman scattering and manufacturing method technology, applied in the micro-nano field, can solve the problems of poor repeatability and stability, low detection sensitivity, and low Raman scattering efficiency of molecules to be measured, so as to improve molecular Raman scattering and enrichment effect of ability

Inactive Publication Date: 2010-07-14
INST OF OPTICS & ELECTRONICS - CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The problem to be solved by the present invention is to overcome the shortcomings of the existing rough metal structure substrate and nano metal sol in improving the Raman scattering efficiency of the molecules to be measured, low detection sensitivity, poor repeatability and stability, and provide a method for enhancing molecular Raman scattering. The substrate manufacturing method, the substrate utilizes the localized plasmon resonance enhancement effect of the metal micro-nano structure, adopts a surface modification layer, improves the external medium environment, and at the same time increases the number of molecules to be analyte enriched by the substrate and enhances the Raman scattering efficiency of the molecules to be analysed, realizing Efficient and maximized output of Raman scattering of molecules to be measured to meet the needs of high-sensitivity detection

Method used

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  • Production method of basement for enhancing raman scattering of molecule
  • Production method of basement for enhancing raman scattering of molecule
  • Production method of basement for enhancing raman scattering of molecule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] In TNT gas trace detection, the preparation method of the present invention is:

[0029] (1) Choose K9 glass as the base substrate, put it into the washing solution made of concentrated sulfuric acid with a concentration of 90% to 98% and hydrogen peroxide H2SO4: 30% H2O22 to 4:1 and heat it to 80°C to 120°C for 30 to 60 minutes , to remove impurities, then rinse repeatedly, then put ammonia, hydrogen peroxide and water into the solution NH3:H2O2:H2O / 1:1:5 for ultrasonic treatment for 20 to 60 minutes, then take out the substrate for repeated washing, save, and ready for use;

[0030] (2) Design a hexagonal triangular metal nanostructure, the metal structure material is gold, the characteristic size is 100nm, the period is 500nm, and the thickness is 10nm. The plasmon resonance frequency of this structure is about 420nm. Fabricating a metal micro-nano structure 2 on the base substrate 1 by nanoimprinting method;

[0031] (3) metallizing the micro-nano structure by vap...

Embodiment 2

[0036] In sucrose solution probing, substrate fabrication is achieved by the following steps

[0037] (1) Silicon is selected as the substrate, cleaned and treated for hydrophilicity.

[0038] (2) A nanostructure with a triangular distribution, a characteristic size of 50nm, and a period of 300nm is produced on the surface of the substrate by self-assembly of nanospheres.

[0039] (3) Metallize the nanostructure by magnetron sputtering, first sputter a layer of metallic silver, and then change the target to sputter a layer of metallic gold to obtain a double-layer metal with 50nm gold and 20nm thick silver Substrates for nanometallic structures.

[0040] (4) If the substrate is directly placed in the solution to be tested for detection, the adsorption of the substrate to be tested is as follows: Figure 4 shown. Add a layer of molecular biofilm 3 to the surface of the substrate and activate it: prepare a 1 mM solution of octanethiol (1-octanethiol, 1-OT) and sulfhydryl-cont...

Embodiment 3

[0043] In the detection of charcoal distance virus powder, the fabrication of the substrate is achieved through the following steps

[0044](1) select germanium as the substrate material, clean and do hydrophilic treatment;

[0045] (2) Nanoimprinting is used to produce a nanostructure layer with a characteristic size of 800nm, a period of 3μm, and a quadrilateral arrangement on the surface of the substrate;

[0046] (3) Metallize the micro-nano structure layer, first sputter a layer of metal gold, then change the target and sputter a layer of metal silver to obtain a nano-metal structure with a double-layer metal of 300nm gold and 100nm thick silver end;

[0047] (4) modifying the surface of the substrate obtained in step (3) to obtain a surface decoration layer, preparing an adsorption film to improve the ability of the substrate to enrich the molecules to be measured, and activating the substrate;

[0048] (5) Adding molecules to be measured to the substrate with the surf...

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Abstract

The invention provides a production method of a basement for enhancing the raman scattering of a molecule, which comprises following steps of: (1) selecting substrate material, cleaning and hydrophilically treating; (2) producing a micro nanometer structure layer on the surface of the substrate; (3) metallizing the micro nanometer structure layer to obtain the substrate with a nanometer metal structure; (4) decorating the surface of the substrate obtained by the step (3) to obtain a surface decoration layer, wherein the surface decoration is preparation of a gas sensitivity interface or a molecule biological film or an adsorbed film or a surface activated material according to the property of the molecule to be tested to improve the property of the basement to enrich the molecule to be tested and the action for activating the basement; (5) adding the molecule to be tested on the substrate with a surface decoration layer; and (6) changing external medium environment around the substrate to improve the enhancement effect of the raman scattering of the molecule to be tested. The external medium environment around the substrate comprises circumambient environment material, or excitation wave length, or optical field distribution or magnetic field distribution. The production method can be used for high sensitivity test; and the substrate has the advantages of high controllability,consistency, repeatability, stability and the like.

Description

technical field [0001] The invention belongs to the field of micro-nano technology, and relates to a substrate for enhancing molecular Raman scattering, in particular to an efficient and high-stability substrate for realizing molecular Raman enhancement by using the local surface plasmon resonance effect and surface modification mechanism of metal nanostructures. Background technique [0002] Raman scattering (RS) is a kind of scattering phenomenon of light. When the photon of the monochromatic incident light interacts with the molecule to be measured, an inelastic collision occurs, energy exchange occurs between the photon and the molecule, and the photon changes the direction and frequency of motion. Scattering occurs. Raman spectroscopy (RS) is known as the fingerprint of molecules. The spectrum is characterized by narrow band and rich information. It is applied to sensing technology, which has high specificity, no sample preparation, and can provide fast, repeatable, Ad...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/65B82B3/00
Inventor 邓启凌杜春雷杨兰英史立芳尹韶云
Owner INST OF OPTICS & ELECTRONICS - CHINESE ACAD OF SCI
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