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Flunarizine orally disintegrating tablet and preparation method thereof

A technology of flunarizine and orally disintegrating tablets, which is applied in the field of flunarizine orally disintegrating tablets and its preparation, can solve the problems of oral discomfort and difficult acceptance by patients, achieve no gritty feeling, reduce production steps, and reduce production costs. cost effect

Inactive Publication Date: 2010-11-24
上海医药科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But when this orally disintegrating tablet containing effervescent agent is used, the oral cavity feels uncomfortable because of producing a large number of bubbles, and the patient is difficult to accept

Method used

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  • Flunarizine orally disintegrating tablet and preparation method thereof
  • Flunarizine orally disintegrating tablet and preparation method thereof
  • Flunarizine orally disintegrating tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1: Flunarizine orally disintegrating tablet preparation 1

[0028] prescription:

[0029] Flunarizine 2.5g

[0030] Sorbitol 100g

[0031] Low-substituted hydroxypropyl cellulose 2.5g

[0032] Tartaric acid 1g

[0033] Magnesium Stearate 2g

[0034]

[0035] Made into 1000 pieces

[0036] Preparation process: first sieve the prescribed amount of flunarizine, sorbitol, low-substituted hydroxypropyl cellulose, and tartaric acid, and mix evenly; then add the prescribed amount of magnesium stearate to the above mixed powder, mix evenly, and directly Tablets are available.

Embodiment 2

[0037] Embodiment 2: Flunarizine orally disintegrating tablet preparation 2

[0038] prescription:

[0039] Flunarizine 5g

[0040] Microcrystalline Cellulose 80g

[0041] Lactose 50g

[0042] Sodium carboxymethyl starch 4g

[0043] Tartaric acid 2g

[0044] Micronized silica gel 2g

[0045] Magnesium Stearate 2g

[0046]

[0047] Made into 1000 pieces

[0048] Preparation process: first sieve the prescribed amount of flunarizine, microcrystalline cellulose, lactose, sodium carboxymethyl starch, and tartaric acid, and mix evenly; then add the prescribed amount of micropowder silica gel and magnesium stearate to the above mixed powder , mixed evenly, and directly compressed into tablets.

Embodiment 3

[0049] Embodiment 3: Flunarizine orally disintegrating tablet preparation 3

[0050] prescription:

[0051] Flunarizine 5g

[0052] Mannitol 200SD 80g

[0053] Lactose 50g

[0054] Crospovidone 10g

[0055] Tartaric acid 4g

[0056] Aspartame 1g

[0057] Micronized silica gel 2g

[0058] Magnesium Stearate 2g

[0059]

[0060] Made into 1000 pieces

[0061]Preparation process: first sieve the prescription amount of flunarizine, mannitol 200SD, lactose, crospovidone, aspartame, and tartaric acid, and mix them evenly; then add the prescription amount of micropowder silica gel, Magnesium stearate, mixed evenly, directly compressed into tablets.

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Abstract

The invention provides a flunarizine orally disintegrating tablet, which consists of flunarizine and pharmaceutic adjuvant, wherein the pharmaceutic adjuvant comprises a filler, a disintegrating agent, a flavoring agent, an effervescing agent, a lubricating agent and the like. Compared with the disintegrating time limit of a common flunarizine tablet, the flunarizine orally disintegrating tablet has the characteristic of quick response. Mouthfeel observation experiments show that the flunarizine orally disintegrating tablet has good mouthfeel and is easy to be accepted by the patient. In vitro dissolution experiment results show that the bioavailability of the flunarizine orally disintegrating tablet is obviously higher than that of the common flunarizine tablet. The flunarizine orally disintegrating tablet can be quickly dispersed without water or swallow action, and has the advantages of no sand feel, good patient compliance, quick response, and high bioavailability; meanwhile, the preparation process is simple and suitable for industrial production.

Description

technical field [0001] The invention relates to a pharmaceutical preparation, in particular to an orally disintegrating tablet dosage form, in particular to a flunarizine orally disintegrating tablet and a preparation method thereof. Background technique [0002] Flunarizine, chemical name (E)-1-[bis(4-fluorophenyl)methyl]-4-2(2-propenyl-3-phenyl)-piperazine, is a calcium channel Blocker drugs. The main pharmacological effects of flunarizine are: (1) relieve vasospasm, and have a lasting inhibitory effect on the persistent vasospasm caused by vasoconstrictor substances, especially on the basilar artery and internal carotid artery, and its effect is stronger than that of naoyizine 15 times; (2) vestibular inhibition, can increase cochlear arteriole blood flow, improve vestibular organ circulation; (3) antiepileptic effect, can block pathological calcium overload of nerve cells and prevent paroxysmal depolarization, cell (4) protect the myocardium and significantly reduce is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/495A61P7/02A61P9/10A61P25/06A61P25/08
Inventor 黄君勤曾垂宇苏恩云商鼎
Owner 上海医药科技发展有限公司
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