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Predation method of D-glucosamine hydrochloride

A technology of glucosamine hydrochloride and hydrochloric acid, which is applied in the field of medicine and chemical industry, can solve the problems of restricting the production and practical application of glucosamine hydrochloride products, long product production cycle, high hydrolysis temperature, etc., so as to shorten the hydrolysis reaction time and product cost Low, less environmental pollution effect

Inactive Publication Date: 2010-12-15
BINHAI NACHUAN MINSHENG CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method requires high hydrolysis temperature, long hydrolysis time, and low product yield, resulting in long product production cycle, high production cost, and relatively large environmental pollution, which severely limits the production of glucosamine hydrochloride products. and practical application

Method used

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  • Predation method of D-glucosamine hydrochloride
  • Predation method of D-glucosamine hydrochloride
  • Predation method of D-glucosamine hydrochloride

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0019] Get 200g of dried citric acid mycelium residue containing Aspergillus niger (Mucar rouxii) (from Jiangsu Yixing Xielian Biochemical Co., Ltd.) raw material in a distillation three-necked flask, add 12mol / L hydrochloric acid (HCL) 310ml, heat to 85 ℃ and keep warm for 30min, add dropwise 30% hydrogen peroxide (H 2 o 2 ) 7.5ml, under microwave conditions (pressure 0.3MPa, use 80% of total power 2kw, time 300s, XT-9900 intelligent microwave digestion instrument) to continue hydrolysis for 1.5h;

[0020] Filtrate the reaction mixture while it is hot, concentrate the filtrate under reduced pressure at 80°C to 20% of the original volume, and then cool to room temperature. After filtration, 12 grams of crude crystals are obtained. The crude product is dissolved in 36 grams of water, and 6g of activated carbon is added and incubated at 70°C for 30 minutes. Suction filtration, concentration under reduced pressure (temperature<70°C) to 20-30% of the original volume, cooling and ...

Embodiment approach 2

[0023] Take 500 g of dried citric acid mycelium residue containing Aspergillus niger (Mucar rouxii) (from Jiangsu Yixing Xielian Biochemical Co., Ltd.) raw material in a three-neck distillation flask, add 775 ml of 12mol hydrochloric acid (HCL), heat to 90 ° C and Keep warm for 1h, add dropwise 30% hydrogen peroxide (H 2 o 2 ) 15ml, under microwave conditions (pressure 0.4MPa, use 70% of the total power 2kw, time 300s) to continue hydrolysis for 1h;

[0024] Filter the reaction mixture while it is hot, concentrate the filtrate under reduced pressure at 80°C to 20% of the original volume, and then cool to room temperature. After filtration, 29 grams of crude crystals are obtained. The crude product is dissolved in 100 grams of water, and 20 g of activated carbon is added at 70° C. for 30 minutes. , suction filtration,

[0025] 8. He Yancai, Xu Qingqing, Xu Yanhong, Zhuang Yongjin. Extraction of chitin and chitosan from Aspergillus niger [J]. Biotechnology, 2000, (4).

[0026...

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Abstract

The invention discloses a predation method of D-glucosamine hydrochloride, belonging to the field of pharmaceutical chemicals. The predation method of the D-glucosamine hydrochloride comprises the following step of: preparing the D-glucosamine hydrochloride through hydrolysis under microwave promotion by taking filamentous fungi as raw materials and a hydrochloric acid and hydrogen peroxide as oxidizers. Compared with the traditional production process of the D-glucosamine hydrochloride, because the hydrogen peroxide is adopted as the additional oxidizer and the oxidative degradation of the raw materials is promoted by adopting a microwave radiation technology, the predation method can reduce the using amount of the hydrolytic hydrochloric acid by 30 percent and greatly shorten the time of hydrolysis reaction; in addition, the time of the hydrolysis reaction is shortened within 2 hours, and the yield of a product is enhanced to 2.9-3.4 percent.

Description

Technical field: [0001] The invention belongs to the field of medicine and chemical industry, and relates to a preparation method of D-glucosamine hydrochloride. Background technique: [0002] D-glucosamine hydrochloride (D-Glucosamine Hydrochloride, GAH) is an important derivative of chitin, white crystalline powder, molecular formula C 6 h 13 NO 5 HCI 【1，2】 . [0003] GAH has important physiological significance in the human body: it can participate in liver and kidney detoxification, and has anti-inflammatory and liver-protecting effects 【3】 ; It can be used to treat rheumatoid arthritis and gastric ulcer disease; used in combination with antibiotics, it can promote the absorption of antibiotics in the blood and reduce side effects; it can also inhibit the growth of cancer cells 【4】 . In the food industry, GAH is not only an important trace sugar component added to infant formula, but also a starting material for the synthesis of VB6 and riboflavin intermediates, an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12P19/02C12R1/785C12R1/645C12R1/685
Inventor 贺君陈俊
Owner BINHAI NACHUAN MINSHENG CHEM
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