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Composition containing enrofloxacin hexahydrate and application thereof to preparation of medicaments for treating or preventing diseases of domestic animals

A hexahydrate, enrofloxacin technology, applied in the field of veterinary medicine, can solve the problem of inability to determine enrofloxacin hexahydrate, lack of drug stability, drug metabolism, biochemical tests and challenge tests, lack of drug stability, Drug metabolism biochemical test and drug challenge test to achieve broad market prospects and value, good clinical effect, and the effect of promoting absorption and utilization

Inactive Publication Date: 2011-01-05
LUOYANG HUIZHONG ANIMAL MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are currently researches on the preparation and identification methods of enrofloxacin hexahydrate, but there is a lack of drug stability, drug metabolism, biochemical tests and methods for enrofloxacin hexahydrate and its composition for treating or preventing livestock diseases. Research on the challenge experiment
Especially for common livestock bacterial diseases and mycoplasma infection diseases, such as: mycoplasma pneumonia, pasteurellosis, colibacillosis, salmonellosis, streptococcal disease, actinomyces pleuropneumonia, mastitis, colibacillosis, pasteuria Bacterial disease and mastitis, etc., lack of research on drug stability, drug metabolism, biochemical tests and challenge tests, it is impossible to determine whether enrofloxacin hexahydrate can replace enrofloxacin and its combination currently widely used in veterinary clinics drug

Method used

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  • Composition containing enrofloxacin hexahydrate and application thereof to preparation of medicaments for treating or preventing diseases of domestic animals
  • Composition containing enrofloxacin hexahydrate and application thereof to preparation of medicaments for treating or preventing diseases of domestic animals
  • Composition containing enrofloxacin hexahydrate and application thereof to preparation of medicaments for treating or preventing diseases of domestic animals

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Example 1 Preparation of a composition drug containing 5% W / V enrofloxacin hexahydrate in terms of enrofloxacin (the same below) and its drug metabolism and efficacy test

[0050] 1. Preparation of Enrofloxacin Hexahydrate

[0051] Take 8L of isopropanol / water with a volume ratio of 1:1 and add it to a 10L reaction bottle, add 400g of enrofloxacin (Zhejiang Guobang Pharmaceutical Co., Ltd., batch number: 091122-6), stir and suspend at room temperature for one week, filter , the filter cake was washed twice with cold water, 4L each time, and the filter cake was placed at room temperature to dry naturally to obtain enrofloxacin hexahydrate.

[0052] Structural identification of enrofloxacin hexahydrate: identified by infrared spectroscopy and X-ray diffraction, see the infrared spectrum and X-ray diffraction patterns respectively figure 1 (The ordinate represents the absorption intensity, and the abscissa represents the wave number), figure 2 (The ordinate indicates in...

Embodiment 2

[0141] Example 2 Preparation of a composition containing 10% W / V enrofloxacin hexahydrate in terms of enrofloxacin (the same below) and its drug metabolism and drug efficacy test

[0142] 1. For the preparation of enrofloxacin hexahydrate, refer to Example 1 for the test method.

[0143] 2. Preparation of compositions and medicines containing 10% W / V enrofloxacin hexahydrate

[0144] 1) Preparation of 10% W / V enrofloxacin hexahydrate composition

[0145] Enrofloxacin hexahydrate: 10% W / V

[0146] Co-solvent: KOH 2%W / V

[0147] Preservative: n-Butanol 3% W / V

[0148] Carrier: water for injection to the full amount of 1000ml

[0149] Preparation steps:

[0150] 1) Preparation of KOH solution: Weigh 20g of KOH, add 100ml of water for injection, stir to dissolve and set the volume to 200ml;

[0151] 2) Mix 600ml of water for injection and 30g of n-butanol evenly, and control the temperature at 20°C-30°C during mixing;

[0152] 3) Add 135.1 g of enrofloxacin hexahydrate and ...

Embodiment 3

[0176] Example 3 Preparation of a composition containing 2% W / V enrofloxacin hexahydrate in terms of enrofloxacin (the same below) and its pharmacokinetic and efficacy tests

[0177] 1. For the preparation of enrofloxacin hexahydrate, refer to Example 1 for the test method.

[0178] 2. Preparation of 2% W / V enrofloxacin hexahydrate composition

[0179] Enrofloxacin hexahydrate: 2% W / V

[0180] Co-solvent: NaOH 0.4%W / V

[0181] Preservative: n-Butanol 5% W / V

[0182] Carrier: propylene glycol 25% V / V, water for injection to 1000ml

[0183] Preparation steps:

[0184] 1) Preparation of KOH solution: Weigh 4g of NaOH, add 50ml of water for injection, stir to dissolve and then dilute to 100ml;

[0185] 2) Take 600ml of water for injection and mix with 50g of n-butanol evenly, and control the temperature at 20°C-30°C during mixing;

[0186] 3) Add 27.0 g of enrofloxacin hexahydrate and stir to mix evenly;

[0187] 4) Slowly add the above NaOH solution and mix well;

[0188]...

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Abstract

The invention relates to a composition containing enrofloxacin hexahydrate and application thereof to the preparation of medicaments for treating or preventing diseases of domestic animals and mycoplasma infection diseases. The composition has the characteristics of high in-vivo plasma peak concentration of the domestic animals, high bioavailability, and pharmacokinetics and clinical effect superior to those of enrofloxacin composition medicaments, can replace enrofloxacin and a composition thereof, is applied to the preparation of veterinary medicaments which are used clinically and widely, and has the wide market prospect and high value.

Description

technical field [0001] The invention relates to a composition containing enrofloxacin hexahydrate and its application in the preparation of medicines for treating or preventing bacterial or mycoplasma infectious diseases in livestock, belonging to the field of veterinary medicine. Background technique [0002] Quinolones antibiotics are one of the most clinically used antibiotics in modern times. Quinolones antibiotics have been applied and developed for half a century. Many quinolones antibiotics with new characteristics are coming out continuously and widely used clinically. Enrofloxacin (ethyl ciprofloxacin) is the first fluoroquinolone drug specially used for livestock. It was first developed by Bayer in Germany in the 1980s and successfully developed in China in 1993. Enrofloxacin is a broad-spectrum antibacterial drug, which has the characteristics of broad antibacterial spectrum, strong bactericidal activity, wide distribution in the body, and no cross-resistance with...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/496A61P31/04A61P11/00A61P15/00
Inventor 张许科刘兴金李兴国
Owner LUOYANG HUIZHONG ANIMAL MEDICINE
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