Carbon foam biological scaffold as well as preparation method and application thereof

Abstract

The invention discloses a carbon foam biological scaffold as well as a preparation method and application thereof. The carbon foam biological scaffold is formed by carbonizing porous organic foam and phenolic resin adhered on the surface of the pore wall of the organic foam which are taken as presoma. The preparation method of the carbon foam biological scaffold comprises the following steps: processing the organic foam into a porous scaffold template; placing the porous scaffold template into the ethanol solution of the phenolic resin for dipping, drying the porous scaffold template, carrying out microwave heating and curing and the like to form the presoma of the carbon foam scaffold, and sintering through carbonization to obtain the carbon foam biological scaffold. The carbon foam biological scaffold has excellent aperture opening ratio and biocompatibility, and can be widely applied to the in vitro cell culture.

Description

technical field [0001] The invention relates to a tissue engineering biological material and its preparation method and application, in particular to a biological scaffold and its preparation method and application. Background technique [0002] Tissue engineering is an emerging discipline that uses the basic principles and methods of engineering science and life science to research and develop biological substitutes to restore, maintain and improve the function of human tissue. It belongs to the multidisciplinary and interdisciplinary field. Its research mainly includes Three aspects: seed cells, biomaterial scaffolds and growth factors. In recent years, with the progress of cell biology, molecular biology, informatics and computer science, finding ideal extracellular scaffold materials has become a research hotspot at this stage. [0003] The spatial structure composed of tissue engineering scaffold materials provides a place for cells to obtain nutrition, gas exchange an...

AI Technical Summary

Problems solved by technology

A large number of studies have shown that natural bio-scaffold materials are generally non-toxic, hydrophilic, and biocompatible, but their cost is relatively high, difficult to process and poor in repeatability; therefore, synthetic polymer bio-scaffolds are more commonly used in tissue engineering , such as polycaprolactone (PCL), polycaprolactide (PGA), polylactide (PLA) and its copolymer caprolactide-lactide (PLGA), etc., these materials have certain mechanical strength, performance Controllable, and can improve biological activity through a series of surface modifications, it is currently the most widely used biological scaffold material

[0005] Although a lot of research has been done on natural biomaterials (such as collagen and chitosan, etc.) (such as cell attachment, degradable regulation, biological activity, etc.) are still not well resolved

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