Method for preparing photo-curable bone repairing material from epoxy group-containing siloxane-clad modified hydroxyapatite

A hydroxyapatite and siloxane technology, which is applied in the field of biocomposite medical materials, can solve problems such as inorganic particle/polymer matrix interface fracture, achieve biocompatibility, improved mechanical properties, simple preparation process, and good biological properties. Effects of Compatibility and Mechanical Properties

Inactive Publication Date: 2011-02-09
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Lack of adhesion between the two phases often leads to fracture at the inorganic particle / polymer-based interface

Method used

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  • Method for preparing photo-curable bone repairing material from epoxy group-containing siloxane-clad modified hydroxyapatite
  • Method for preparing photo-curable bone repairing material from epoxy group-containing siloxane-clad modified hydroxyapatite

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Weigh 5.0 g of nano-hydroxyapatite, suspend it in 40.0 mL of ethyl acetate, stir it electromagnetically, control the temperature at 5° C., and protect it with nitrogen. Add dropwise an ethyl acetate solution in which 10.0 g of propyltriethoxysilane isocyanate and dibutyltin dilaurate are dissolved, react for 3 hours, wash, centrifuge, and dry in vacuo. Take 0.2g of the dried sample, 1.0g of water, 3.0g of 3-glycidyloxypropyltrimethoxysilane, and the photoinitiator diazonium salt content is 1.0% of the system, add 0.1mL of hydrochloric acid and 0.2mL of ethanol, Let the solution system slowly form a white gel, at a light intensity of 10mW / cm 2 , Polymerized for 5 minutes under a UV lamp with a wavelength of 200-500nm to obtain the product.

Embodiment 2

[0020] Weigh 5.0 g of nano-hydroxyapatite, suspend it in 40.0 mL of tetrahydrofuran, stir it electromagnetically, control the temperature at 20° C., and protect it with nitrogen. A tetrahydrofuran solution dissolved with 10.0 g of propyltrimethoxysilane isocyanate and triethylenediamine as a catalyst was added dropwise, and after reacting for 3 hours, it was washed, centrifuged, and dried in vacuum. Take 0.8g of dried sample, 1.0g of water, 3.0g of 3-glycidyl etheroxypropylmethyl diethoxysilane, and the content of photoinitiator diaryliodonium salt / 651 is 1.0% of the system, add 0.1mL ammonia water and 1.0mL methanol, let the solution system slowly form a white gel, under the light intensity of 50mW / cm 2 , Polymerized for 10 minutes under a UV lamp with a wavelength of 200-500nm to obtain the product. After mechanical property testing, the compressive strength of the sample is 650MPa.

Embodiment 3

[0022] Weigh 5.0 g of nano-hydroxyapatite, suspend it in 40.0 mL of N,N-dimethylformamide, stir it electromagnetically, control the temperature at 100° C., and protect it with argon. Add 10.0g of 3-glycidyl etheroxypropyltriethoxysilane and catalyst dimethylimidazole nitrogen, nitrogen-dimethylformamide solution dropwise, and react for 3 hours, wash, centrifuge, and vacuum dry . Take 1.6g of the dried sample, 1.0g of water, 3.0g of 3-glycidyloxypropyltriethoxysilane, the content of the photoinitiator triarylsulfonium salt is 1.0% of the system, add 0.1mL of sodium hydroxide and propanol 1.0mL, let the solution system slowly form a white gel, under the light intensity of 200mW / cm 2 , The product was obtained by polymerizing for 20 minutes under a UV lamp with a wavelength of 200-500nm. After mechanical property testing, the compressive strength of the sample was 650MPa.

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Abstract

The invention discloses a method for preparing a photo-curable bone repairing material from epoxy group-containing siloxane-clad modified hydroxyapatite, which belongs to the field of research on biomedical composite materials. The method comprises the following steps of: performing surface grafting modification on the hydroxyapatite; cladding the modified hydroxyapatite in siloxane by a sol gel method; and performing UV photopolymerization. The photo-curable bone repairing material has high biocompatibility and mechanical property and hydrophilcity; moreover, the material is in a flowing viscous sol state before being cured, so the material can be combined with tissues and subjected to injection molding for repairing the random defects of the tissues in vivo.

Description

technical field [0001] The invention relates to a method for preparing a light-cured bone repair material by coating modified hydroxyapatite with epoxy-containing siloxane, and belongs to the research field of biocomposite medical materials. Background technique [0002] Hydroxyapatite is a slightly water-soluble calcium salt of weakly alkaline phosphoric acid. It is also the main inorganic component of human bone tissue, accounting for more than 70% of human bone tissue. After implanted in the body, under the action of body fluids, calcium and Phosphorus will dissociate from the surface of the material to be absorbed by body tissues and grow new tissues. Compared with other inorganic materials, hydroxyapatite has high chemical stability and wear resistance, and has good biological activity and biocompatibility, so it is one of the potential biological materials. Synthetic nanoscale hydroxyapatite bioceramics are widely used in the repair of bone injuries due to their simil...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/50A61L27/46C08G77/44C08G77/14
Inventor 聂俊苏丹畅文凯马贵平
Owner BEIJING UNIV OF CHEM TECH
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