Method for extracting aucubin from aucuba japonica leaves

A technology for aucubin and aucubin, which is applied in the field of extracting aucubin by using macroporous resin and membrane separation technology, can solve the problems of large amount of organic reagents, high cost, only suitable for scientific research experiments, etc. Less, less harm, better effect
CN101974049AInactive Publication Date: 2011-02-16NANJING ZELANG AGRI DEV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
NANJING ZELANG AGRI DEV
Publication Date
2011-02-16
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a method for extracting aucubin from aucuba japonica leaves, which comprises the following steps of taking the aucuba japonica leaves as a raw material; extracting for 2 to 3 times by utilizing ethanol in a microwave mode; recovering the ethanol from an extracting solution; adding water in extract to be dispersed and filtered; adding a polarity macroporous resin column to absorb; eluting with 50 to 70% of the ethanol; ultra-filtering eluent by utilizing an ultra-filtration membrane; concentrating by utilizing a nano-filtration membrane; extracting a concentrated solution by adding ethyl acetate; concentrating and crystallizing the extracting solution; and washing crystals with chloroform and petroleum ether and drying in a low temperature and vacuum conditions. The process of the invention has the advantages of simple operation, low energy consumption, high extraction efficiency, the obtained product has high content, and the temperature in the process of production is easy to control. The method of the invention is easy to product in industrialization.
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Description

Technical field:

[0001] The present invention relates to a method for extracting aucubin from leaves of coral coral, in particular to a method for extracting aucubin by adopting macroporous resin and membrane separation technology. Background technique:

[0002] Aucubin is an iridoid glycoside.

[0003] Molecular formula: C 15 h 22 o 9 ;

[0004] Molecular weight: 346.33;

[0005] Molecular formula:

[0006]

[0007] Physical and chemical properties: Melting point 181°C (ethanol-ether), easily soluble in water, methanol, soluble in ethanol, insoluble in ether, chloroform, benzene and petroleum ether.

[0008] Aucubin is widely found in plants, especially in the genus Aucubin, which has the highest content. Pharmacological studies have shown that aucubin has the functions of clearing damp heat, diuresis, analgesia, lowering blood pressure, protecting liver and liver, and anti-tumor.

[0009] Aucubin Aucubin has a bisacetal structure in its molecular structure, whic...

Claims

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