Nanoparticle-reinforced polyether-ether-ketone joint prosthesis material as well as preparation method and application thereof

A polyetheretherketone, nanoparticle technology, applied in medical science, prosthesis and other directions, can solve the problems of replacement joint failure, short service life, high surgical technical requirements, and achieve the effect of improving hardness and wettability and reducing wear and tear.

Inactive Publication Date: 2011-05-18
NANJING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ultra-high molecular weight polyethylene/metal artificial joints are currently widely used clinically due to their price advantage. However, after long-term use, ultra-high molecular weight polyethylene will produce a large amount of wear and tear debris, which will lead to osteoly

Method used

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  • Nanoparticle-reinforced polyether-ether-ketone joint prosthesis material as well as preparation method and application thereof
  • Nanoparticle-reinforced polyether-ether-ketone joint prosthesis material as well as preparation method and application thereof
  • Nanoparticle-reinforced polyether-ether-ketone joint prosthesis material as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1: Polyetheretherketone powder is selected, with an average particle size of 100 μm; the filling material is crystalline nano-Al 2 o 3 Powder with a purity of 99% and an average particle size of 80nm.

[0024] The preparation process of the composite material is as follows:

[0025] (1) Screening polyether ether ketone powder with a sieve with an aperture of 100 μm;

[0026] (2) Use stearic acid coupling agent to nanometer Al 2 o 3 Particle surface modification;

[0027] (3) the mass fraction is respectively 0%, 1%, 3%, 5%, 7%, 9% nano-Al 2 o 3 Put the powder and PEEK powder into a ball mill tank, and wet mix them under ethanol solution. The speed of the ball mill is 200 rpm, and each mixing process is clockwise and counterclockwise for 60 minutes;

[0028] (4) Ultrasonic dispersion is carried out for 10 minutes to the powder after wet mixing, and then dried in a drying oven;

[0029] (5) Pour the mixed powder into the mold cavity, about 40 grams each ti...

Embodiment 2

[0033] Example 2: Select polyether ether ketone powder, the average particle size is 100 μm; the filling material is crystal nano-Al 2 o 3 Powder with a purity of 99% and an average particle size of 20nm.

[0034] The preparation process of the composite material is as follows:

[0035] (1) Screening polyether ether ketone powder with a sieve with an aperture of 100 μm;

[0036] (2) Use stearic acid coupling agent coupling agent to nanometer Al 2 o 3 Particle surface modification;

[0037] (3) the mass fraction is respectively 0%, 1%, 3%, 5%, 7%, 9% nano-Al 2 o 3 Put the powder and PEEK powder into a ball mill tank, and wet mix them under ethanol solution. The speed of the ball mill is 200 rpm, and each mixing process is clockwise and counterclockwise for 60 minutes;

[0038] (4) Ultrasonic dispersion is carried out for 10 minutes to the powder after wet mixing, and then dried in a drying oven;

[0039] (5) Pour the mixed powder into the mold cavity, about 40 grams eac...

Embodiment 3

[0043] Example 3 selects polyether ether ketone powder, with an average particle size of 100 μm; the filling material is crystal nano-Al 2 o 3 Powder with a purity of 99% and an average particle size of 100nm.

[0044] The preparation process of the composite material is as follows:

[0045] (1) Screening polyether ether ketone powder with a sieve with an aperture of 100 μm;

[0046] (2) Use stearic acid coupling agent coupling agent to nanometer Al 2 o 3 Particle surface modification;

[0047] (3) the mass fraction is respectively 0%, 1%, 3%, 5%, 7%, 9% nano-Al 2 o 3 Put the powder and PEEK powder into a ball mill tank, and wet mix them under ethanol solution. The speed of the ball mill is 200 rpm, and each mixing process is clockwise and counterclockwise for 60 minutes;

[0048] (4) Ultrasonic dispersion is carried out for 10 minutes to the powder after wet mixing, and then dried in a drying oven;

[0049] (5) Pour the mixed powder into the mold cavity, about 40 grams ...

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Abstract

The invention discloses a nanoparticle-reinforced polyether-ether-ketone joint prosthesis material as well as a preparation method and application thereof. Nanoparticles filled in polyether-ether-ketone serve as crosslinking points to form a polymer composite material of a net crosslinking structure; the composite material is used as manual hip joint in a joint prosthesis; the inner surface layer of the hip joint is made of a nanoparticle-reinforced polyether-ether-ketone joint prosthesis material, and the thickness of the inner surface layer is 2-4mm; and the outer surface layer of the hip joint is made of polyether-ether-ketone, and the thickness of the outer surface layer is 8-10mm. The nanoparticle/PEEK (polyether-ether-ketone) composite material prepared by the preparation method has low nanoparticle filling amount which is less than 10wt%. The abrasive resistance of the preferable composite material is improved by 8 times compared with that of the pure PEEK, a friction coefficient is lowered to 1/2 of that of the pure PEEK; the hardness and wettability of the nanoparticle-reinforced PEEK composite material are improved, and abrasion on friction couples can be lightened.

Description

technical field [0001] The invention belongs to implant materials and devices, in particular to a nanoparticle-reinforced polyetheretherketone artificial joint material and its preparation method and application. Background technique [0002] Polyether ether ketone (PEEK for short) is a semi-crystalline aromatic thermoplastic engineering plastic with excellent performance. It not only has excellent properties such as high temperature resistance, creep resistance, fatigue resistance, and wear resistance, it is called a super plastic; Moreover, it is a widely used biocompatible material, and its excellent biocompatibility has been confirmed by many in vivo and in vitro experiments, and has broad application prospects in the field of biomedicine. [0003] Nanoparticles are atomic groups or molecular groups composed of a very small number of atoms or molecules. They have the characteristics of small size effects, surface effects, and quantum size effects, which make them composi...

Claims

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Application Information

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IPC IPC(8): A61L27/44A61L27/46A61L27/50
Inventor 熊党生
Owner NANJING UNIV OF SCI & TECH
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