Preparation method of biological ceramic coating rich in calcium and phosphate phases on surface of magnesium alloy

A bioceramic and magnesium alloy technology, applied in the field of materials, can solve the problems of stress shielding, poor biological activity, inflamed tissue, etc., achieve good corrosion resistance and wear resistance, improve compactness and thickness, and stabilize spark discharge.

Active Publication Date: 2011-10-19
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

First, toxic metal ions or particles may be released during corrosion and wear, which can lead to inflammation and even tissue damage
Furthermore, since its elastic modulus does not match well with natural bone tissue, it is easy to cause stress shielding
Stress shielding reduces stimulation of new bone growth and remodeling and ultimately reduces implant stability
Third, current metal biomaterials are usually made into plates, threads, and needles to repair severe fractures. They are neutral in the body and exist in the form of permanent fixation. After the tissue heals, it must pass through a secondary Surgically removed, repeated surgeries increase patient infection rates and distress
At present, some bioceramic membranes prepared by micro-arc oxidation have problems such as small surface pores, a small proportion of dense layers, too fast coating degradation, and poor biological activity.

Method used

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  • Preparation method of biological ceramic coating rich in calcium and phosphate phases on surface of magnesium alloy
  • Preparation method of biological ceramic coating rich in calcium and phosphate phases on surface of magnesium alloy
  • Preparation method of biological ceramic coating rich in calcium and phosphate phases on surface of magnesium alloy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1 Preparation of a calcium-phosphorus-rich bioceramic coating on the surface of a magnesium alloy

[0038] Proceed as follows:

[0039] (1) Preparation of electrolyte: add (C 6 h 5 o 7 ) 2 Ca 3 4H 2 O as a calcium source, and adding Na 3 PO 4 As a phosphorus additive, add KOH, NH at the same time 4 HF 2 , N(CH 2 CH 2 Oh) 3 , C 3 h 8 o 3 and H 2 o 2 , to prepare an electrolyte with a certain concentration ratio of calcium to phosphorus. Among them, the concentration of KOH is 0.0891mol / L, NH 4 HF 2 The concentration is 0.1227mol / L, N(CH 2 CH 2 Oh) 3 The volume fraction is 0.5%, C 3 h 8 o 3 The volume fraction is 0.5%, H 2 o 2 The volume fraction is 0.75%;

[0040] The calcium source in the electrolyte used in each group of samples (C 6 h 5 o 7 ) 2 Ca 3 4H 2 O and phosphorus additive Na 3 PO 4 The specific content of is shown in Table 1-1:

[0041] Table 1-1 Composition and content of calcium and phosphorus sources in micro-arc...

Embodiment 2

[0050] Example 2 Preparation of a calcium-phosphorus-rich bioceramic coating on the surface of a magnesium alloy

[0051] Proceed as follows:

[0052] (1) Preparation of electrolyte: add (C 6 h 5 o 7 ) 2 Ca 3 4H 2 O as a calcium source, and adding Na 3 PO 4 As a phosphorus additive, add KOH, NH at the same time 4 HF 2 , N(CH 2 CH 2 Oh) 3 , C 3 h 8 o 3 and H 2 o 2 , to prepare an electrolyte with a certain concentration ratio of calcium to phosphorus. Among them, (C 6 h 5 o 7 ) 2 Ca 3 4H 2 The concentration of O is 0.005mol / L, Na 3 PO 4 The concentration of KOH is 0.005mol / L, the concentration of KOH is 0.0891mol / L, and the concentration of NH 4 HF 2 The concentration is 0.1227mol / L, N(CH 2 CH 2 Oh) 3 The volume fraction is 0.5%, C 3 h 8 o 3 The volume fraction is 0.5%, H 2 o 2 The volume fraction is 0.75%;

[0053] (2) Preparation of base material: Divide the plate into 8×10×12mm by wire cutting 3 Drill holes and tap threads on the small su...

Embodiment 3

[0065] Example 3 Preparation of bioceramic coatings rich in calcium and phosphorus phases on the surface of magnesium alloys

[0066] Proceed as follows:

[0067] (1) Preparation of electrolyte: add (C 6 h 5 o 7 ) 2 Ca 3 4H 2 O as a calcium source, and adding Na 3 PO 4 As a phosphorus additive, add KOH, NH at the same time 4 HF 2 , N(CH 2 CH 2 Oh) 3 , C 3 h 8 o 3 and H 2 o 2 , to prepare an electrolyte with a certain concentration ratio of calcium to phosphorus. Among them, (C 6 h 5 o 7 ) 2 Ca 3 4H 2 O is 0.005mol / L, Na 3 PO 4 is 0.005mol / L, the concentration of KOH is 0.0891mol / L, and the concentration of NH 4 HF 2 The concentration is 0.1227mol / L, N(CH 2 CH 2 Oh) 3 The volume fraction is 0.5%, C 3 h 8 o 3 The volume fraction is 0.5%, H 2 o 2 The volume fraction is 0.75%;

[0068] (2) Preparation of base material: Divide the plate into 8×10×12mm by wire cutting 3 Drill holes and tap threads on the small surface of the cuboid to facilitate ...

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Abstract

The invention relates to a preparation method of a biological ceramic coating rich in calcium and phosphate phases on the surface of magnesium alloy, comprising the following steps of: adding (C6H5O7)2Ca3.4H2O and Na3PO4 to deionized water, and simultaneously adding KOH, NH4HF2, N(CH2CH2OH)3, C3H8O3 and H2O2 to prepare an electrolyte with a certain concentration ratio of calcium and phosphate; disposing the magnesium alloy in the electrolyte as an anode which is prepared through micro arc oxidation energization reaction. The calcium-phosphate ceramic coating obtained by the preparation methodconsists of three layers of a loose layer, a transition layer and a compact layer, wherein the surface of the loose layer consists of a plurality of uniformly distributed micropores, the transition layer is between the loose layer and the compact layer, and the compact layer and a substrate body form good metallurgical bonding; therefore, the coating has high rigidity, high density, high bonding force and good corrosion resistance and abrasion resistance; simultaneously, the mouse acute systemic toxicity test indicates that the coating has good biocompatibility, and the simulated body fluid soaking test indicates that the coating has good biological activity.

Description

technical field [0001] The invention relates to a preparation method of a bioceramic coating, which belongs to the technical field of materials. Background technique [0002] Due to their high mechanical strength and fracture toughness, metal materials are more suitable for repairing human tissues with certain load-bearing requirements than ceramic or organic materials. Metallic biomaterials currently recognized and widely used include stainless steel, titanium, and cobalt-chromium-based alloys. These metallic biomaterials have many limitations. First, toxic metal ions or particles may be released during corrosion and wear, which can lead to inflammation and even tissue damage. Furthermore, since its elastic modulus does not match well with natural bone tissue, it is easy to cause stress shielding. Stress shielding reduces the stimulation of new bone growth and remodeling and ultimately reduces the stability of the implant. Third, current metal biomaterials are usually m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C25D11/30C25D11/36
Inventor 陈传忠潘尧坤王佃刚于慧君
Owner SHANDONG UNIV
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