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Traditional Chinese medicine composition with effect of preventing and treating cancers and application of Chinese medicinal composition

A composition and technology of traditional Chinese medicine, applied in the field of traditional Chinese medicine composition, can solve the problems of human toxic and side effects, limit the curative effect of drugs, and low immune function, and achieve the effects of avoiding liver damage, effectively preventing and treating cancer, and avoiding side effects

Active Publication Date: 2014-03-05
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the treatment of cancer, although the traditional radiotherapy and chemotherapy have made great progress, because it kills cancer cells, it also produces different degrees of toxic side effects on the human body, mainly bone marrow suppression and low immune function. Cause leukopenia, etc., and sometimes even have to interrupt treatment, which also limits the efficacy of drugs

Method used

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  • Traditional Chinese medicine composition with effect of preventing and treating cancers and application of Chinese medicinal composition
  • Traditional Chinese medicine composition with effect of preventing and treating cancers and application of Chinese medicinal composition
  • Traditional Chinese medicine composition with effect of preventing and treating cancers and application of Chinese medicinal composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Example 1 (Ethanol Extract of Semen Xanthophylla, Ethanol Extract of Angelica Sinensis, and the Composition of Ethanol Extract of Semen Xanthophyll Angelica Sarcoma S180 Solid Tumor in Mice)

[0014] The present invention first investigates the effect of ET and angelica ethanol extract (AE) composition on mouse sarcoma S180 solid tumor.

[0015] 1.1 Experimental materials

[0016] 1.1.1 Test animals

[0017] ICR mice, Weight 18-22g, purchased from Shanghai Slack Experimental Animal Co., Ltd., animal certificate number: SCXK (Shanghai 2007-0005). The mice were reared at a temperature of (22±1)°C, a relative humidity of (65±10)%, and lighting time of 12 hours per day.

[0018] 1.1.2 Test drug and its preparation

[0019] Ethanol extract (ET) of Xanthogonia chinensis tuber slices coarse powder, extracted three times with 10 times the amount of 80% ethanol for 3 hours each time, the filtrates were combined and then concentrated under reduced pressure until there was no...

Embodiment 2

[0036] Example 2 (composition powder suspension, water extract, 70% ethanol extract, ethyl acetate extract, acetone extract, 120# gasoline extract, artificial gastric juice extract in vivo anti-tumor effect research)

[0037] After confirming that the ethanol extract composition of xanthophyll angelica has strong anti-S180 solid tumor effect, the present invention further investigates the in vivo anti-tumor effect of the suspension of the traditional Chinese medicine composition of the present invention and various extracts thereof.

[0038] 2.1 Experimental materials

[0039] 2.1.1 Test animals (same as 1.1.1 of Example 1)

[0040] 2.1.2 Test drug and its preparation

[0041] The whole powder suspension of the composition: 36g of xanthophyll, 36g of angelica, pulverized, passed through a 150-mesh sieve, and suspended in 180mL of distilled water.

[0042] Water extract of the composition: 36g of xanthophyllum, 36g of angelica, add 10 times the amount of water, reflux extract...

Embodiment 3

[0054] Embodiment 3 (in vitro anticancer activity research of Chinese medicine composition and active ingredient thereof)

[0055] Through whole animal experiments, it is found that the Chinese medicine composition of the present invention has an anti-tumor effect, and the inventor separates and obtains diterpene lactones component lutein B (Kawasaki T, Komori T, Setoguchi S. Furanoid norditerpenes from Dioscoreacae plants.1.Diosbulins A, B, and C from Dioscorea bulbifera form a spontanea.Chem Pharm Bull, 1968; 16:2430-2435.) (purity above 98%); isolated and purified from Angelica sinensis polysaccharide (Shang Peng , Yang Tiehong, Jia Min, Mei Qibing, Zhao Wenming, Cao Zhixian, Zhao Dehua. Separation, purification and analysis of Angelica polysaccharides. Journal of Fourth Military Medical University, 2001, 22(14): 1311-1314.) (content at 95% above), organic acid components ferulic acid (Sun Y, Li S, Song H, Tian S. Extraction of ferulic acid from Angelica sinensis with super...

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Abstract

The invention discloses a composition with an effect of preventing and treating cancers. The composition is mainly prepared from the following Chinese herbal medicines in percentage by mass: 20 to 85 percent of airpotato yam rhizome and 15 to 80 percent of Chinese angelica. The Chinese medicinal composition has the effect of preventing and treating the cancers, can eliminate the limit that liver injury is easily induced by chemotherapeutic medicinal medicines, is suitable for treating various cancers such as liver cancer, gastric cancer, breast cancer, lung cancer, bladder cancer, ovarian cancer, prostate cancer, esophagus cancer, pancreatic cancer, colon cancer, colorectal cancer, skin cancer, thyroid cancer, cervical carcinoma, leukemia and the like, can be used for preparing anti-cancer medicaments, realizes the application of the airpotato yam rhizome and Chinese angelica compositions to the preparation of medicaments for treating the cancers, develops the application range and the medicinal value of the airpotato yam rhizome and the Chinese angelica and makes creative contribution to the development of traditional Chinese medicine.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition capable of preventing and treating cancer. In addition, the present invention also relates to the medical application of the traditional Chinese medicine composition. Background technique [0002] Cancer is one of the major diseases that seriously threaten human health and life. In the treatment of cancer, although the traditional radiotherapy and chemotherapy have made great progress, because it kills cancer cells, it also produces different degrees of toxic side effects on the human body, mainly bone marrow suppression and low immune function. Cause leukopenia, etc., sometimes even have to interrupt treatment, which also limits the efficacy of drugs. In order to overcome a series of ills caused by traditional radiotherapy and chemotherapy, pharmaceutical workers have been exploring continuously in recent years, and the application of herbal medicines to prevent and treat cancer has...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8945A61P35/00
Inventor 王峥涛季莉莉王君明刘海王长虹
Owner SHANGHAI UNIV OF T C M
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