Intra-intestinal nutrient emulsion for tumor patients and preparation method thereof

An enteral nutrition emulsion, a technology for cancer patients, applied in the field of enteral nutrition emulsion, can solve the problems of poor fat utilization and achieve the effect of enhancing the body's resistance and promoting immune function

Inactive Publication Date: 2012-02-08
费森尤斯卡比华瑞制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Studies on animals and humans have found that body tissues can use fat as an energy substrate without restriction, but tumors use glucose poorly due to the lack of key enzymes that oxidize free fatty acids and degrade ketone bodies. Oxidation for energy

Method used

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  • Intra-intestinal nutrient emulsion for tumor patients and preparation method thereof
  • Intra-intestinal nutrient emulsion for tumor patients and preparation method thereof
  • Intra-intestinal nutrient emulsion for tumor patients and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] The feeding formula is shown in Table 3 below.

[0040] Table 3 Example 1 feeding formula.

[0041] Vitamin D3 (100000IU / g)

1.984mg

Biotin

0.125mg

folic acid

0.141mg

Thiamine hydrochloride

1.664mg

riboflavin sodium phosphate

2.504mg

Pyridoxine Hydrochloride

2.112mg

Vitamin B12

3.280μg

lactose

0.653mg

Nicotinamide

10.800mg

thbrthdrexvbdr

5.040mg

Vitamin K1

0.095mg

glucose

9.425 mg

Vitamin C

448mg

Maltodextrin (DE value 11-16)

58.936g

sucrose

25.6g

sodium caseinate

42.16g

whey protein

11.2g

inulin

5.974g

soybean polysaccharide

7.04g

potassium citrate

1.992g

magnesium oxide

0.104g

calcium phosphate

0.208g

calcium carbonate

0.552g

magnesium chloride

0.768g

potassium chloride

1g ...

Embodiment 2

[0054] The feeding formula is shown in Table 5 below.

[0055] Table 5 embodiment 2 feeding formula

[0056]

[0057]

[0058] The preparation method is the same as in Example 1.

[0059] Table 6 below shows the test results of the product after 0 months and 12 months of airtight storage below 25°C (not frozen).

[0060] Table 6 embodiment 2 product airtight storage after 12 months inspection result

[0061]

[0062]

Embodiment 3

[0064] The feeding formula is shown in Table 7 below.

[0065] Table 7 embodiment 3 feeding formula

[0066]

[0067]

[0068] The preparation method is the same as in Example 1.

[0069] The test results of the products after 0 months and 12 months of airtight storage below 25°C (not frozen) are shown in Table 8 below.

[0070] The inspection result after 12 months of table 8 embodiment 3 product airtight preservation

[0071]

[0072]

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PUM

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Abstract

The invention relates to an intra-intestinal nutrient emulsion for tumor patients and a preparation method thereof, belonging to the technical field of nutrient medicament preparation. The intra-intestinal nutrient emulsion is prepared by preparation of primary emulsion, dilution, storage, packaging, and sterilization. The intra-intestinal nutrient emulsion contains protein, fat, carbohydrates, vitamins, minerals, microelements, dietary fibers and other nutrients. The energy distribution of the intra-intestinal nutrient emulsion is as follows: 18% of protein, 50% of fat and 32% of carbohydrates, thereby increasing the energy supply ratio of fat and reducing the energy supply ratio of carbohydrates. The intra-intestinal nutrient emulsion is designed according to the tumor patients and meets the metabolism need of the tumor patients. The whole production process of the emulsion is carried out under nitrogen protection, and through sterilization of a rotary sterilization kettle, the effective ingredients of the product can be better retained.

Description

technical field [0001] The invention relates to an enteral nutrition emulsion which is especially suitable for use by tumor patients, and also relates to a preparation method thereof, which belongs to the technical field of preparation of nutritional medicines. Background technique [0002] Epidemiological studies have found that cancer patients are a group with a high incidence of malnutrition, and cachexia usually indicates a poor prognosis. Cancer cachexia has been found as a common symptom as early as 1932. The incidence of malnutrition in tumor patients is as high as 65%, and about 22% of tumor patients die directly from malnutrition. Malnutrition in tumor patients can lead to: consumption of lean tissue mass and weight loss; delayed wound healing; decreased immune function; reduced tolerance and sensitivity to various treatments; multi-organ dysfunction or failure; length of hospital stay Prolonged, the cost increases; the case fatality rate and mortality rate increas...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K38/17A61P3/02A61K31/07A61K31/122A61K31/14A61K31/194A61K31/196A61K31/22A61K31/23A61K31/355A61K31/375A61K31/4184A61K31/4415A61K31/455A61K31/51A61K31/519A61K31/525A61K31/593A61K31/661A61K31/70A61K31/7004A61K31/7016A61K31/714A61K31/715A61K31/733A61K33/04A61K33/08A61K33/10A61K33/14A61K33/16A61K33/18A61K33/24A61K33/30A61K33/32A61K33/34A61K33/42A61K35/12A61K35/60A61K36/55
Inventor 陈晋苏
Owner 费森尤斯卡比华瑞制药有限公司
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