Application of iridoid in preparation of anti-osteoporosis medicines

An iridoid and osteoporosis technology, which is applied in the field of medicine, can solve the problems of not knowing the active substances of Ligustrum lucidum, not deeply researching the active ingredients of Ligustrum lucidum, etc., so as to promote the differentiation of osteocytes and promote the proliferation of cells. , the effect of promoting alkaline phosphatase activity
CN102389440BInactive Publication Date: 2014-08-20魏园
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
魏园
Publication Date
2014-08-20
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the technical field of medicine, and relates to the application of an iridoid compound in the preparation of anti-osteoporosis drugs. The application of the iridoid compound of general formula I of the present invention in the preparation of medicines for treating and / or preventing osteoporosis. The experiment found that the extract of iridoids with the general formula I was tracked and separated based on the ALP activity in UMR106 cells, and the effects of the extract and the separated components on osteoblast proliferation and antioxidant activity Research has been carried out, showing that the iridoid compounds with the general formula I can significantly promote the activity of alkaline phosphatase and promote the differentiation of osteoblasts, so this type of compound has an anti-osteoporosis effect and can be used to prepare Medicines to treat or prevent osteoporosis. Among them, privetin and compound G13 have the effect of significantly promoting the activity of alkaline phosphatase and promoting the differentiation of osteoblasts, and the effect of privetin can also significantly promote the proliferation of UMR-106 cells, which is used for anti-osteoporosis When the effect is better.
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Description

technical field

[0001] The invention belongs to the technical field of medicine, and in particular relates to the application of iridoid compounds in the preparation of anti-osteoporosis drugs. Background technique

[0002] Osteoporosis is a disease characterized by damage to the microstructure of bone tissue, a decrease in the proportion of bone mineral composition and bone matrix, bone thinning, a decrease in the number of bone trabeculae, increased bone fragility, and increased risk of fracture. Diseases of systemic bone metabolism disorders. Osteoporosis has become an important issue affecting the health of our people and social medical security, and has become the second leading cause of death in the elderly, second only to cardiovascular and cerebrovascular diseases. According to the survey, it is estimated that in 2006, about 69.44 million people (15.34 million males and 54.1 million females) suffered from osteoporosis, and about 213.9 million people had low bone mas...

Claims

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