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Preparation method of super-micro molecular iron dextran

A technology of ultra-micromolecular dextran and molecular dextran, which is applied in the field of preparation technology of glucose polymer and iron dextran to achieve the effects of shortening complexation time, reducing production costs and reducing emissions

Active Publication Date: 2012-05-02
GUANGXI RES INST OF CHEM IND CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to overcome the problems existing in the above oxidation process, complexation process and desalination process, and reduce potential safety hazards in production, the present invention improves the oxidation, complexation and desalination processes in the synthesis process of iron dextran

Method used

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  • Preparation method of super-micro molecular iron dextran

Examples

Experimental program
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Effect test

example 1

[0025] (1) Application of hydrogen peroxide / alkali solution to oxidize ultra-fine molecular dextran

[0026] In a 500ml three-necked flask heated with a stirrer and a water bath, add 18g of ultra-micromolecular dextran (weight average molecular weight of 3000-6000Da) and 40ml of purified water, start the stirrer, heat up to 80°C, gelatinize for 20 minutes, and then add 7g , 30% sodium hydroxide solution, then add 9ml, 20% hydrogen peroxide solution, after adding, react for 50 minutes to obtain an orange-red solution, and then reduce the solution temperature to room temperature, neutralize it with 6N hydrochloric acid solution to pH is 4.0-5.0, the oxidized ultra-micromolecule dextran solution is obtained.

[0027] (2) Preparation of ultra-micromolecular iron dextran

[0028] The oxidized ultra-micromolecule dextran solution prepared by the above method is heated to 80 ° C while stirring, and 100 ml of 35% ferric chloride solution and 80 ml of 30% sodium hydroxide solution are...

example 2

[0031] (1) Application of hydrogen peroxide / alkali solution to oxidize ultra-fine molecular dextran

[0032] In a 500ml three-necked flask heated with a stirrer and a water bath, add 18g of ultra-micromolecular dextran (weight average molecular weight of 3000-6000Da) and 35ml of purified water, start the stirrer, heat up to 60°C, gelatinize for 40 minutes, and then add 9g , 20% sodium hydroxide solution, then add 6ml, 25% hydrogen peroxide solution, after adding, react for 30 minutes to obtain an orange-red solution, and then reduce the solution temperature to room temperature, neutralize it with 6N hydrochloric acid solution to pH is 4.0-5.0, the oxidized ultra-micromolecule dextran solution is obtained.

[0033] (2) Preparation of ultra-micromolecular iron dextran

[0034]The oxidized ultrafine molecular dextran solution prepared by the above method was heated up to 65°C while stirring, and 120ml of 35% ferric chloride solution and 83ml of 35% sodium hydroxide solution were...

example 3

[0037] (1) Application of hydrogen peroxide / alkali solution to oxidize ultra-micromolecular dextran

[0038] In a 500ml three-necked flask equipped with a stirrer and heated by a water bath, add 18g of ultra-micromolecular dextran (weight average molecular weight 3000-6000Da) and 70ml of purified water, start the stirrer, heat up to 70°C, gelatinize for 30 minutes, and then add 6g , 40% sodium hydroxide solution, then add 2ml, 27% hydrogen peroxide solution, after the addition, react for 20 minutes to obtain an orange-red solution, then lower the solution temperature to room temperature, and neutralize it to pH with 6N hydrochloric acid solution If it is 4.0-5.0, an oxidized ultramicromolecular dextran solution is obtained.

[0039] (2) Preparation of Ultrafine Molecular Iron Dextran

[0040] The oxidized ultramicromolecular dextran solution prepared by the above method was heated up to 90°C while stirring, and 90ml of 30% ferric chloride solution and 75ml of 25% sodium hydro...

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Abstract

The invention discloses a method for preparing super-micro molecular iron dextran by using super-micro molecular dextran (a weight-average molecular weight being 3,000-6,000Da) as a raw material. After the super-micro molecular dextran is subjected to oxidation, complexing, desalting, concentration preparation, filtration and encapsulation sterilization, an iron dextran injection product with an iron content of 25-250 mg / ml can be obtained, and the super-micro molecular iron dextran can be used for preventing and treating the iron-deficiency anemia of piglets and livestocks. According to the method for preparing the super-micro molecular iron dextran, a conventional potassium cyanide method and an alkali method are replaced by adopting oxydol / aqueous alkali oxidation, and a sodium hypochlorite method is improved; an alcohol precipitation method is replaced by using an electric dialyser method to remove the sodium chloride in iron dextran solution; simultaneously, the impurity removal working procedure of an intermediate product is further omitted; the production cost is decreased; the energy consumption is decreased; the production period is shortened; the toxicity is decreased; the emission of waste gas, waste water and industrial residues is reduced; the environmental pollution is reduced; and the production potential safety hazard caused by the usage of flammable and explosive alcohol is eliminated.

Description

technical field [0001] The invention relates to a preparation method of a glucose polymer, also known as iron dextran, in particular to a preparation process of iron dextran with a weight average molecular weight of 3000-6000 Da, which is mainly used as an iron supplement and belongs to the field of fine chemicals. Background technique [0002] Dextran (dextran) is a kind of high molecular polymer formed by the polymerization of several glucose, also known as dextran. Due to the different number of polymerized glucose molecules, products with different molecular weights are produced, including: high molecular weight dextran (weight average molecular weight) 100-200kDa), medium-molecular dextran (weight-average molecular weight 60-80kDa), low-molecular-weight dextran (weight-average molecular weight 20-40kDa), small-molecular-weight dextran (weight-average molecular weight 10-20kDa), micromolecular dextran (weight-average molecular weight 7-10kDa) ) and special micromolecule ...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/721A61P7/06A61P3/12
Inventor 许朝芳张丽娟柯敏李致宝韦少平翁德洪
Owner GUANGXI RES INST OF CHEM IND CO LTD
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