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Method for preparing bioactive glass ceramic material for bone defect restoration

A technology of bioactive glass and bioglass, applied in medical science, prosthesis, etc., can solve the problems of high brittleness and low mechanical strength, and achieve the effect of large output, good mechanical strength, and simple and easy preparation process

Inactive Publication Date: 2012-05-02
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, traditional bioglass scaffolds generally have the disadvantages of high brittleness and low mechanical strength.

Method used

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  • Method for preparing bioactive glass ceramic material for bone defect restoration
  • Method for preparing bioactive glass ceramic material for bone defect restoration

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Using Na 2 O-CaO-SiO 2 -P 2 o5 Bioglass powder.

[0035] (1) After fully mixing 58.63g sodium carbonate, 52.33g calcium carbonate, 18.36g tricalcium phosphate and 63.00g silicon dioxide, put them into a platinum crucible and melt at 1400°C for 120min, then pour the molten glass into deionized water Quenching with water to obtain amorphous phase bioactive glass. After filtering out the water, dry in an electric blast drying oven at 60°C for 24 hours, ball mill in a planetary ball mill at a speed of 480rpm for 3 hours, and pass through a 200-mesh sieve to obtain Na 2 O-CaO-SiO 2 -P 2 o 5 Biological glass powder, each material is composed of: 24.5% calcium oxide, 6g phosphorus pentoxide, 24.5% sodium oxide, 45% silicon dioxide;

[0036] (2) Add 100g Na 2 O-CaO-SiO 2 -P 2 o 5 The bio-glass powder was added to 100mL polyacrylamide solution with a volume fraction of 6%, and ball milled for 3 hours to mix to obtain a bio-glass slurry with a volume fraction of 50%;

...

Embodiment 2

[0040] Using Na 2 O-CaO-SiO 2 -P 2 o 5 Bioglass powder and CaO-SiO 2 -P 2 o 5 A mixture of bioglass powders, where Na 2 O-CaO-P 2 o 5 -SiO 2 The mass fraction of biological glass powder is 99%, CaO-P 2 o 5 -SiO 2 The mass fraction of biological glass powder is 1%.

[0041] (1) Mix 59.82g of sodium carbonate, 53.40g of calcium carbonate, 15.30g of tricalcium phosphate and 63.00g of silicon dioxide, put them into a platinum crucible and melt at 1400°C for 120min, then pour the molten glass into deionized Quenching in water to obtain amorphous phase bioactive glass, after filtering out the water, dry in an electric blast drying oven at 60°C for 24h, ball mill in a planetary ball mill at a speed of 480rpm for 3h, and pass through a 200-mesh sieve to obtain Na 2 O-CaO-SiO 2 -P 2 o 5 Biological glass powder, each material is composed of: 25% calcium oxide, 5g phosphorus pentoxide, 25% sodium oxide, 45% silicon dioxide;

[0042] (2) Add 18.72mL of deionized water, 3....

Embodiment 3

[0047] Using Na 2 O-CaO-SiO 2 -P 2 o 5 Bioglass powder and CaO-SiO 2 -P 2 o 5 A mixture of bioglass powders, where Na 2 O-CaO-P 2 o 5 -SiO 2 The mass fraction of biological glass powder is 50%, CaO-P 2 o 5 -SiO 2 The mass fraction of biological glass powder is 50%.

[0048] (1)) After fully mixing 39.32g sodium carbonate, 35.09g calcium carbonate, 13.11g tricalcium phosphate and 48.00g silicon dioxide, put them into a platinum crucible and melt at 1400°C for 120min, then pour the molten glass into Quenching in ionized water to obtain amorphous phase bioactive glass. After filtering the water, dry it in an electric blast drying oven at 60°C for 24 hours, ball mill it in a planetary ball mill at a speed of 480rpm for 3 hours, and pass through a 200-mesh sieve to obtain Na 2 O-CaO-SiO 2 -P 2 o 5 Biological glass powder, the composition of each material is: 23% calcium oxide, 6% phosphorus pentoxide, 23% sodium oxide and 48% silicon dioxide;

[0049] (2) Add 93.6m...

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Abstract

The invention discloses a method for preparing a bioactive glass ceramic material for bone defect restoration, which comprises the steps of: sieving the biological glass powder, adding the polyacrylamide solution, ball milling and mixing uniformly to obtain the biological glass slurry; pouring the slurry into a macromolecular reverse mould by centrifugal grouting, curing, drying and sintering at a temperature of between 900 DEG C and 1000 DEG C controlled by a program to remove the macromolecular reverse mould to prepare the bioactive glass ceramic material for bone defect restoration. The shape of the bioactive glass ceramic material for bone defect restoration prepared by the invention can be decided according to clinical demand, and the bioactive glass ceramic material for bone defect restoration has good mechanical strength, biocompatibility and degradability, high compression strength, good anti-dispersion performance and activity and adjustable and controllable degradation time. The preparation method provided by the invention has a simple process and low cost.

Description

technical field [0001] The invention belongs to the field of bioactive materials, and relates to bone tissue repair, filling and tissue engineering repair materials, in particular to a preparation method of bioactive glass-ceramic materials used for bone defect repair. Background technique [0002] Skeletal lesion is a clinical common disease and frequently-occurring disease. Through the development of bone repair and bone substitute materials, it can help patients repair defective or missing bone tissue and better restore the function of human tissue. In bone tissue engineering, an ideal repair material should meet the following conditions: good biocompatibility, biodegradability, plasticity, three-dimensional porous and interconnected pore structure and certain mechanical strength. In the field of bone defect repair research, there is an urgent need for scaffold materials that match the mechanical strength of human bone, have good cell compatibility, and promote the growt...

Claims

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Application Information

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IPC IPC(8): C03C10/00A61L27/10
Inventor 陈晓峰李正茂赵娜如
Owner SOUTH CHINA UNIV OF TECH
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