Kukoamine B salt, preparation method thereof and purpose thereof

A technology of chrysanthemum and its compounds, which are applied in the preparation of carboxylic acid amides, chemical instruments and methods, and the preparation of organic compounds, and can solve problems such as unsure curative effect, septic shock, adverse effects, etc.
CN102464591AActive Publication Date: 2012-05-23THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
Publication Date
2012-05-23

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Abstract

The invention relates to a kukoamine B salt, a preparation method thereof and a purpose of the kukoamine B salt in preparation of medicines for preventing and treating sepsis. Experiments show that the kukoamine B salt has a good inhibition effect on main pathogenic factors mediating the sepsis and can be used to prepare medicines for preventing and treating the sepsis. The kukoamine B salt and various pharmaceutically acceptable carriers and / or diluents can be prepared into various preparations, so an efficient control means is provided for such intractable diseases on condition that definite and effective sepsis treatment measures are clinically lacked at present.
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Description

technical field

[0001] The invention belongs to the technical field of medicines, and in particular relates to a chrysamine B salt, a preparation method thereof, and an application of the chrysamine B salt in the preparation of medicines for preventing and treating sepsis. Background technique

[0002] Sepsis is an infectious agent-mediated systemic inflammatory response syndrome (systemic inflammatory response syndrome, SIRS), which is a common complication in patients with burns, trauma, tumors and infectious diseases, and has become a globally recognized cause of intensive care unit disease. The leading cause of death in (ICU) patients. The existing clinical treatment methods for sepsis are mainly the early use of antibiotics and the correction of ischemic hypoxic damage, and the conventional treatment of organ failure and shock. There is no specific treatment. Drug treatment is usually based on empirical use of non-specific drugs such as glucocorticoids, insulin, and im...

Claims

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