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Euonymus alatus extract, blood-sugar-reducing activity thereof and application of euonymus alatus extract to preparation of products for reducing blood sugar

A technology of extract and ghost arrow feather, applied in the application field of preparation of hypoglycemic products, can solve problems such as gastrointestinal reactions, get rid of causes and prevent complications

Inactive Publication Date: 2012-06-27
石任兵
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The current hypoglycemic drugs are still mainly Western medicines, which have side effects such as hypoglycemia and gastrointestinal reactions, and cannot fundamentally eliminate the cause and prevent complications

Method used

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  • Euonymus alatus extract, blood-sugar-reducing activity thereof and application of euonymus alatus extract to preparation of products for reducing blood sugar
  • Euonymus alatus extract, blood-sugar-reducing activity thereof and application of euonymus alatus extract to preparation of products for reducing blood sugar
  • Euonymus alatus extract, blood-sugar-reducing activity thereof and application of euonymus alatus extract to preparation of products for reducing blood sugar

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] Embodiment 1: Capsules

[0068] Get 1 kg of ghost arrow feather, 50% ethanol 16L reflux extraction 3 times, extract 1.5 hours each time, recover the solvent under reduced pressure to dryness, add water to dilute, make the solution concentration be 0.05g / mL (calculated by the amount of crude drug), at 4000 Centrifuge for 15min at a rotating speed of rpm, take the supernatant and pass it through 3LAB~8 macroporous adsorption resins, the adsorption flow rate is 3BV / h, the diameter-height ratio of the resin column is 1:9, and the sample loading is 0.25g / mL (based on the amount of raw medicinal materials). ), washed with water for 3 times the volume of the resin, the impurity removal flow rate was 3BV / h, 70% ethanol was eluted for 5 times the resin volume, and the elution flow rate was 3BV / h, the 70% ethanol eluate was collected, the solvent was recovered, and dried under reduced pressure. That is to obtain the ghost arrow feather extract of the present invention, add conven...

Embodiment 2

[0074] Embodiment 2: tablet

[0075] Get 1 kg of ghost arrow feather, 70% ethanol 16L reflux extraction 2 times, extract 2 hours each time, recover the solvent under reduced pressure to dryness, add water to dilute, make the solution concentration be 0.1g / mL (in terms of raw medicinal material), at 3000 Centrifuge for 20min at a speed of rpm, take the supernatant and pass it through 3L SP825 macroporous adsorption resin, the adsorption flow rate is 6BV / h, the diameter-to-height ratio of the resin column is 1:12, and the sample loading is 0.5g / mL (based on the amount of crude drug) ), washed with water for 5 times of resin volume, the impurity removal flow rate is 6BV / h, 50% ethanol elutes 6 times of resin volume, and the elution flow rate is 6BV / h, collects 50% ethanol eluate, reclaims solvent, and drys under reduced pressure, namely Obtain the ghost arrow feather extract of the present invention, add conventional adjuvant, make tablet according to conventional process.

[00...

Embodiment 3

[0081] Embodiment 3: pill

[0082] Take 1 kg of ghost arrow feather, decoct 3 times with 12L of water, extract for 1 hour each time, recover the solvent under reduced pressure to dryness, add water to dilute to make the solution concentration 0.15g / mL (based on the amount of crude drug), and extract at 2500 rpm Centrifuge at a speed of 10 minutes for 30 minutes, take the supernatant and prepare it by liquid-liquid countercurrent extraction method, extract with petroleum ether to remove fat-soluble impurities, then extract with ethyl acetate and n-butanol, and recover the solvent to dryness to obtain the ghost arrow feather extraction of the present invention Add conventional excipients, and make pills according to the conventional process.

[0083] Determination method of total flavonoid content:

[0084] Preparation of reference substance solution: Weigh an appropriate amount of catechin reference substance, accurately weigh it, put it in a 10ml volumetric flask, add methano...

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Abstract

The invention relates to a euonymus alatus extract and a preparation process, a quality control method, the blood-sugar-reducing activity of the euonymus alatus extract and application of the euonymus alatus extract to the preparation of products for reducing blood sugar. The euonymus alatus extract can be prepared by any one of a solvent extracting method, a macroporous adsorbent resin method, a supercritical fluid extraction method, column chromatography, liquid-liquid counter-current partition chromatography and the like or a combination of the methods. The prepared euonymus alatus extract comprises the following active ingredients: flavonoids, phenols, alkaloids, triterpenoids, sterides, organic acids and polysaccharides, wherein the flavonoids and the phenols are main ingredients, and the content of general flavones is between 5 and 100 weight percent. Blood-sugar-reducing experiments of mice which suffer from diabetes caused by mesoxyalyurea prove that the raising of the blood sugar after the intragastric administration of glucose is inhibited effectively, and the euonymus alatus extract has a certain treatment effect on experimental diabetes caused by pancreas islet beta cell injury caused by the mesoxyalyurea, and can be applied to the preparation of the products for reducing the blood sugar.

Description

technical field [0001] The invention relates to a ghost arrow feather extract, its preparation process, its quality control method, its hypoglycemic activity and its application in the preparation of hypoglycemic products. Background technique [0002] With the increasing prevalence of diabetes mellitus (DM) year by year, diabetes has seriously threatened human health. Diabetes is a diabetes mellitus caused by genetic factors, immune dysfunction, microbial infection and its toxins, free radical toxins, mental factors, etc. , protein, fat, water and electrolytes and a series of metabolic disorder syndromes often lead to serious complications such as coronary heart disease, stroke, thrombosis, diabetic nephropathy, diabetic retinopathy, peripheral arterial occlusion and edema, etc. [0003] The current hypoglycemic drugs are still mainly western medicines, which have side effects such as hypoglycemia and gastrointestinal reactions, and cannot fundamentally get rid of the caus...

Claims

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Application Information

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IPC IPC(8): A61K36/37A61P3/10A23L1/29A23L33/00
Inventor 石任兵张兰珍姜艳艳巴寅颖刘倩颖
Owner 石任兵
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