Method for preparing manganese dioxide nanoparticles with bovine serum albumin as template

A technology of bovine serum albumin and manganese dioxide, which is applied in the field of controlled synthesis of manganese dioxide nanoparticles based on bovine serum albumin as a biological template, can solve the problems of harsh experimental conditions, poor dispersibility, complicated operation, etc. Good biocompatibility, mild effect

Inactive Publication Date: 2012-06-27
SICHUAN UNIV
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  • Abstract
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Problems solved by technology

[0006] The purpose of the present invention is to solve the defects of harsh experimental conditions, complex operation, poor dispersion, easy agglomeration, and large particle size in the traditional method for synthesizing manganese dioxide, and to provide a method using bovine serum albumin as a biological template to control the synthetic particle size to A Simple Preparation Method of 4.8 nm Manganese Dioxide

Method used

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  • Method for preparing manganese dioxide nanoparticles with bovine serum albumin as template
  • Method for preparing manganese dioxide nanoparticles with bovine serum albumin as template
  • Method for preparing manganese dioxide nanoparticles with bovine serum albumin as template

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Embodiment 1

[0021] During the preparation process, add 10 mL of 25 mg bovine serum albumin, 0.01 mol L -1 The phosphate buffer solution of the above-mentioned solution was put into four 50 mL single-necked bottles, and then 5 μmol of manganese acetate, manganese chloride, manganese sulfate or manganese nitrate solution were added respectively, stirred at a constant speed on a magnetic stirrer for 2 min, and the reaction temperature was 20 °C at room temperature. Then add 50 μL, 1 mol L -1 Sodium hydroxide aqueous solution, continue to stir for 6-8 hours, the solution becomes a stable system. After 48 hours of dialysis and high-speed centrifugation, the nano-particle manganese dioxide with uniform particle size can be obtained. Store at 4°C.

Embodiment 2

[0023] During the preparation process, add 10 mL of 25 mg bovine serum albumin, 0.01 mol L -1 The phosphate buffer solution of the solution was put into three 50 mL single-necked bottles, and then 5 μmol manganese acetate solution was added respectively, and stirred at a constant speed on a magnetic stirrer for 2 min, and the reaction temperature was 20 °C at room temperature. Then add 50 μL, 1 mol L -1 Sodium hydroxide aqueous solution, potassium hydroxide aqueous solution or ammonia water, continue to stir for 6-8 hours, the solution becomes a stable system. After 48 hours of dialysis and high-speed centrifugation, the nano-particle manganese dioxide with uniform particle size can be obtained. Store at 4°C.

Embodiment 3

[0025] During the preparation process, add 10 mL of 25 mg bovine serum albumin, 0.01 mol L -1 The phosphate buffer solution of the solution was put into eleven 50 mL single-necked bottles, and then 5 μmol manganese acetate solution was added, stirred at a constant speed on a magnetic stirrer for 2 min, and the reaction temperature was 20 °C at room temperature. Then add different amounts of 1 mol L -1 The sodium hydroxide aqueous solution adjusted the pH to 8.10, 8.35, 9.06, 10.00, 10.68, 10.90, 11.28, 11.38, 11.47, 11.54, 11.62, and continued to stir for 6-8 hours, and the solution became a stable system. After 48 hours of dialysis and high-speed centrifugation, the nano-particle manganese dioxide with uniform particle size can be obtained. Store at 4°C.

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Abstract

The invention provides a preparation method for controlling to synthesize manganese dioxide nanoparticles with bovine serum albumin as a biological template, which belongs to the technical field of manganese dioxide synthesis and nano materials. A process has the following steps that: a certain amount of bovine serum albumin is dissolved in phosphate buffer solution, manganese acetate solution is added in, the mixed solution is mixed and reacts for 2min, then sodium hydroxide is added in, the pH value is adjusted to be strong alkaline, the reaction is carried out for 6h to 8h at room temperature, and the manganese dioxide nanoparticles with the grain size of 4.8nm are obtained after 2 days of dialysis and high-speed centrifugal separation. The method has the advantages that: the preparation method is simple, the reaction conditions are mild, the cost is low, little reagent is required, the use is environmental-friendly, and the manganese dioxide nanoparticles with good dispersibility, good stability, good biocompatibility, smaller grain size, consistent dimension and uniform shape and appearance are obtained. We think the manganese dioxide nanoparticles with smaller and uniform grain size have huge potential application prospect in absorption, catalysis, bio-marking and other fields.

Description

technical field [0001] The invention relates to a method for preparing manganese dioxide nanoparticles, which belongs to the technical field of manganese dioxide synthesis and nanomaterials, in particular to a method for controlling the synthesis of manganese dioxide nanoparticles based on bovine serum albumin as a biological template. Background technique [0002] With the increasing development of nanotechnology, the quantum size effect, small size effect, surface effect and macroscopic tunnel effect of nanoparticles have attracted widespread attention. These special properties make nanomaterials have broad application prospects in optics, electricity, magnetism, catalysis and so on. In recent years, manganese dioxide, as an oxide with important industrial uses, has attracted widespread attention in various fields. Therefore, with its unique structure, excellent performance and low cost, nano-manganese dioxide is widely used in secondary batteries, stealth, magnetic mater...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01G45/02B82Y40/00
Inventor 吕弋刘星王琦
Owner SICHUAN UNIV
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