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Method for preparing medical titanium material with long-acting antibacterial property and good biocompatibility

A technology of biocompatibility, titanium material, applied in the field of preparation of functionalized titanium material, can solve the problems of cytotoxicity, inability to achieve antibacterial effect, etc., and achieve low preparation cost, long-term antibacterial performance, and good biocompatibility. Effect

Inactive Publication Date: 2012-07-04
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Previous research results have shown that appropriate nanotube diameter and tube length can promote cell function; titanium dioxide nanotubes have good antibacterial properties after being loaded with antibiotics, but due to the rapid release of antibiotics, they cannot achieve a durable antibacterial effect; titanium dioxide nanotubes in After being loaded with silver nanoparticles, it has relatively long-lasting antibacterial ability, but it has certain toxicity to cells

Method used

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  • Method for preparing medical titanium material with long-acting antibacterial property and good biocompatibility
  • Method for preparing medical titanium material with long-acting antibacterial property and good biocompatibility
  • Method for preparing medical titanium material with long-acting antibacterial property and good biocompatibility

Examples

Experimental program
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Effect test

Embodiment 1

[0028] Example 1. Preparation of medical titanium material with long-term antibacterial properties and good biocompatibility

[0029] a. Pretreatment of titanium material: ultrasonically clean the titanium material with acetone, isopropanol and methanol for 20 minutes, then wash with deionized water 3 times, dry at 40°C, and set aside;

[0030] b. Construction of titanium dioxide nanotube array: Dissolve ammonium fluoride with a 1:1 volume ratio of glycerol-water mixed solution to prepare an ammonium fluoride solution with a concentration of 0.27 mol / L as the electrolyte; obtain step a The titanium material is used as the anode, platinum is used as the cathode, placed in the above ammonium fluoride electrolyte, and anodized at a constant voltage of 30V for 30 minutes; the treated titanium material is washed 5 times with water, dried at 40°C, and ready for use; Referred to as "Titanium Dioxide Nanotubes";

[0031] c. Loading of silver nanoparticles: fix the titanium material obt...

Embodiment 2

[0035] Example 2. Preparation of medical titanium material with long-term antibacterial properties and good biocompatibility

[0036] a. Pretreatment of titanium material: ultrasonically clean the titanium material with acetone, isopropanol and methanol for 20 minutes, then wash with deionized water 3 times, dry at 40°C, and set aside;

[0037] b. Construction of titanium dioxide nanotube array: Dissolve ammonium fluoride with a 1:1 volume ratio of glycerol-water mixed solution to prepare an ammonium fluoride solution with a concentration of 0.25 mol / L as an electrolyte; obtain step a The titanium material is used as the anode, platinum is used as the cathode, placed in the above ammonium fluoride electrolyte, and anodized at a constant voltage of 30V for 45 minutes; the treated titanium material is washed 5 times with water, dried at 40°C, and ready for use; Referred to as "Titanium Dioxide Nanotubes";

[0038] c. Loading of silver nanoparticles: fix the titanium material obta...

Embodiment 3

[0040] Example 3. Preparation of medical titanium material with long-term antibacterial properties and good biocompatibility

[0041] a. Pretreatment of titanium material: ultrasonically clean the titanium material with acetone, isopropanol and methanol for 20 minutes, then wash with deionized water 3 times, dry at 40°C, and set aside;

[0042] b. Construction of titanium dioxide nanotube array: Dissolve ammonium fluoride with a 1:1 volume ratio of glycerol-water mixed solution to prepare an ammonium fluoride solution with a concentration of 0.30mol / L as an electrolyte; obtain step a The titanium material as the anode, platinum as the cathode, placed in the above ammonium fluoride electrolyte, anodized at a constant voltage of 30V for 60 minutes; the treated titanium material was washed 5 times with water, dried at 40°C, and ready for use; Referred to as "Titanium Dioxide Nanotubes";

[0043] c. Loading of silver nanoparticles: fix the titanium material obtained in step b on a ...

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Abstract

The invention discloses a method for preparing a medical titanium material with long-acting antibacterial property and good biocompatibility. The method comprises the following steps of: firstly forming a titanium dioxide nanotube array with regular and orderly height on the surface of the titanium material by anodic oxidation process; then adding a silver salt solution into the titanium dioxide nanotubes by spin-coating process, and heating at a high temperature to make the silver salt decompose into sliver nanoparticles in the titanium dioxide nanotubes; and finally modifying the material surface with a quaternary ammonium salt QAS, to obtain the final product of medical titanium material with long-acting antibacterial property and good biocompatibility. The preparation method is simple, does not need a special equipment and has a low preparation cost.

Description

technical field [0001] The invention belongs to the field of medical materials and relates to a preparation method of a functionalized titanium material. Background technique [0002] Titanium and titanium alloys have an elastic modulus similar to that of human bone, excellent corrosion resistance, good biocompatibility and processing performance. Since the 1970s, they have been widely used as implant materials in dental implants, artificial joints and Dental implants etc. Bacterial infection is one of the most common reasons for failure of biomaterial implants. If severe infection occurs, the implant will need to be removed and a new operation will be required. Therefore, an ideal implant requires not only good biocompatibility but also long-lasting antimicrobial properties. [0003] Previous research results have shown that appropriate nanotube diameter and tube length can promote cell function; titanium dioxide nanotubes have good antibacterial properties after being l...

Claims

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Application Information

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IPC IPC(8): A61K6/04A61L27/42A61L27/54C23C28/00C25D11/26C23C18/08B05D1/40B05D3/00B05D3/06B05D7/14
Inventor 蔡开勇陈秀勇方佳佳来敏
Owner CHONGQING UNIV
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