Traditional Chinese medicine compound preparation for treating acne and seborrheic dermatitis, and preparation method and application of the compound preparation

A seborrheic dermatitis, compound technology, applied in seborrheic dermatitis drugs, using pure Chinese medicine prescription extracts to prepare and treat acne, it can solve the complex pathogenesis of acne and seborrheic dermatitis, low utilization rate of active ingredients, It is difficult to achieve the expected effect and other problems, to achieve the effect of product stability guarantee, significant drug effect and reasonable composition

Inactive Publication Date: 2012-07-25
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The pathogenesis of acne and seborrheic dermatitis is complicated, and it is related to excessive keratinization of hair follicles, increased sebum secretion rate of sebaceous glands, increase and accumulation of microorganisms in hair follicles and sebaceous glands, skin microcirculation disorders, family inheritance, and the use of certain cosmetics and drugs , so the simple use of metronidazole, chloramphenicol, erythromycin and other chemical drugs is difficult to achieve the desired effect, and drug resistance is the biggest drawback of antibiotic application
[0005] Traditional Chinese medicine has the advantages of multi-components, which can simultaneously exert effects on multiple factors of acne and seborrheic dermatitis. However, there are many types of traditional Chinese medicine compound prescriptions, and the simple and old preparation process will lead to low utilization rate of active ingredients, long treatment time and low therapeutic effect. poor disadvantage

Method used

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  • Traditional Chinese medicine compound preparation for treating acne and seborrheic dermatitis, and preparation method and application of the compound preparation
  • Traditional Chinese medicine compound preparation for treating acne and seborrheic dermatitis, and preparation method and application of the compound preparation
  • Traditional Chinese medicine compound preparation for treating acne and seborrheic dermatitis, and preparation method and application of the compound preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] 1. Extraction of active ingredients (effective parts) of traditional Chinese medicine compound:

[0056] (1) Take 50 grams of orris root, crush it into 20-60 mesh powder, extract with 1000 mL of 75% ethanol under reflux for 3-5 times, filter, combine the extracts, recover the ethanol, and obtain the effective parts for later use;

[0057] (2) Take 100g of Ligusticum decoction pieces, 200g of Angelica decoction pieces, 120g of Chuanxiong decoction pieces, 100g of Guizhi decoction pieces, and 80g of Herba Asarum, mix and grind them into 20-60 mesh powders respectively or according to the prescription ratio, add petroleum ether (60℃ -90°C) 1200mL, soak for 3 hours, filter, extract the dregs twice in the same way, combine the petroleum ether extract, recover the petroleum ether under reduced pressure below 40°C, and obtain the effective part;

[0058] (3) Combine the extracts to obtain the effective part of the Chinese medicine compound.

[0059] 2. Preparation of O / W crea...

Embodiment 2

[0076] Embodiment 2 Skin irritation and pharmacodynamics experiment of Chinese medicine compound preparation of the present invention

[0077] 1. Skin irritation test

[0078] 1. Single administration skin irritation test of cream prepared by prescription 1

[0079] Eight healthy New Zealand rabbits were used. The hair on both sides of the rabbit's back and spine was removed with electric clippers 24 hours before the administration, and the two sides were about 5 cm × 10 cm. The experiment used the same body comparison, the left hair removal area was the intact skin test area, the left front was the administration area with 1.0 g of prescription 1 cream, the left back was the control area given the cream blank matrix; the right hair removal area was the damaged skin In the test area, use a sterile No. 7 injection needle to draw a "#" shaped wound on the skin before administration. The length of the wound is 2 cm, and the interval between the wounds is 1 cm. Spend. The right...

Embodiment 3

[0102] Example 3 Therapeutic effect of the cream prepared by prescription 1 on animal acne models

[0103] Animal model preparation: 18 big-eared white rabbits, half male and half male, weighing 2.5±0.5kg. Coal tar acne model was established by smearing coal tar on rabbit ears for 14 days. After modeling, they were randomly divided into 3 groups, namely model group, treatment group and control group.

[0104] Treatment: The model group was smeared with normal saline 3 times a day; the treatment group was smeared with 3.0% cream 3 times a day, 1.0g each time, and recovered after 5 days; the control group was smeared with chloramphenicol tincture, 3 times a day, 1.0mL each time.

[0105] The results of treatment showed that, as figure 1 As shown, compared with chloramphenicol tincture, the 3.0% cream prepared by prescription 1 can significantly improve the skin lesions after 5 days, the rabbit ears are soft, the subcutaneous blood vessels are obvious, the color is similar to t...

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Abstract

The invention discloses a traditional Chinese medicine compound preparation for treating acne and seborrheic dermatitis, comprising an active component extract and adjuvants. The active component extract is prepared from the following raw materials by weight: 2-25 parts of cassia twig, 1-15 parts of Herba Asari (Asarum heterotropoides and/or Asarum sieboldii), and at least two components of 3-35 parts of Angelica sinensis, 3-35 parts of Ligusticum chuanxiong, 1-25 parts of orris root, and 3-30 parts of Rhizoma Ligustici (Ligusticum sinense and/or Ligusticum jeholense). The compound preparation is simple and reasonable in prescription, significant in efficacy, and low in toxic and side effects. The extracts of Angelica sinensis, Ligusticum chuanxiong, Rhizoma Ligustici (Ligusticum sinense and/or Ligusticum jeholense), cassia twig, and Herba Asari (Asarum heterotropoides and/or Asarum sieboldii) are not only the effective fractions for treatment of acne and seborrheic dermatitis, but also act as a skin penetration enhancer for the abovementioned extracts and an orris root extract. According to the invention, the effective components of various medicines are extracted and then prepared into a dosage form for an external use with stable property and high convenience, and the obtained preparation can quickly and effectively treat skin diseases, such as acne and seborrheic dermatitis.

Description

technical field [0001] The invention relates to a traditional Chinese medicine compound preparation for treating acne and seborrheic dermatitis and a preparation method thereof, in particular to preparing a medicine for treating acne and seborrheic dermatitis by using extracts of pure traditional Chinese medicine prescriptions. Background technique [0002] Acne is a chronic inflammatory lesion of hair follicles and sebaceous glands related to sebum metabolism. It is commonly called "acne" because it tends to occur during puberty. The pathogenesis of acne is related to the metabolism of sebum, and puberty is a high-incidence stage. [0003] Seborrheic dermatitis is an inflammatory skin disease that occurs in areas of seborrhea. It mostly occurs in places where there are more sebaceous glands, such as the scalp, face, chest and folds. It is prone to recurrent attacks, often accompanied by folliculitis and blepharitis, and often accompanied by acne and rosacea mite dermatiti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/88A61P17/08A61P17/10
Inventor 王庆伟刘雪英李军昌
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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