Preparation method and application of surface artemisinin molecule imprinting adsorbing material of vegetable sponge

A technology of molecular imprinting and adsorption materials, applied in the direction of selective adsorption, chemical instruments and methods, ion exchange, etc., can solve the problems of uneven distribution of imprinted sites, reduced utilization of imprinted sites, mechanical properties of template leakage, etc. The effect of improving farmers' income, excellent mechanical stability, good physical and chemical stability

Inactive Publication Date: 2013-11-20
UNIV OF JINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method requires a simple device and strong universality, but there are usually the following problems: (1) The controllability is poor during the grinding process, and some irregular particles are inevitably generated, and some imprinted spots are destroyed at the same time.
The qualified particles obtained after sieving are generally less than 50%, resulting in obvious waste; (2) there are too deep embedding of template molecules, difficulty in elution, template leakage and low mechanical properties; (3) uneven distribution of imprinted sites , some of them are located above the particle pores, and their mass transfer rate is faster, while others are embedded in the polymer body, which is affected by steric hindrance, has poor accessibility, and the rate of recombining template molecules is slow, thereby reducing the number of imprinted sites. Utilization of

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] (1) Loofah pretreatment: loofah is derived from loofah fruit, which is obtained by peeling and removing the core, cutting loofah into small pieces, washing with water, drying in vacuum, crushing, and sieving with a 60-mesh sieve;

[0021] (2) Alkaline treatment of loofah: 50% of the total mass of loofah with pulverization, mixed with 5% NaOH solution and 20% ethanol solution to azeotrope for 0.5h, washed with deionized water to pH after cooling is 7, dried at 60°C after suction filtration to obtain alkalized loofah;

[0022] (3) Acylated loofah: Add 5.0g of alkalized loofah and 20g of chloroform into a stoppered conical flask, stir for 10min under the protection of argon, add 2g of acryloyl chloride dropwise with a constant pressure funnel, drop After stirring for 10 minutes, add 3.5 mL of triethylamine dropwise with a constant pressure funnel. After the dropwise addition, stir at room temperature for 24 hours, filter, wash with chloroform and methanol in turn, and dry ...

Embodiment 2

[0026] 1) Loofah pretreatment: loofah is derived from loofah fruit, which is obtained by peeling and removing the core, cutting loofah into small pieces, washing with water, drying in vacuum, crushing, and sieving with a 60-mesh sieve;

[0027] (2) Alkali treatment of loofah: 50% of the total mass of loofah with pulverization, with a concentration of 5% NaOH solution and 20% ethanol solution to mix and immerse in azeotropic 1.0h, wash with deionized water to pH after cooling is 7, dried at 60°C after suction filtration to obtain alkalized loofah;

[0028](3) Acylated loofah: Add 4.0g of alkalized loofah and 15g of chloroform into a stoppered conical flask, stir for 10min under the protection of argon, add 2g of acryloyl chloride dropwise with a constant pressure funnel, drop After stirring for 10 minutes, add 2.5 mL of triethylamine dropwise with a constant pressure funnel. After the dropwise addition, stir at room temperature for 30 hours, filter, wash with chloroform and met...

Embodiment 3

[0032] (1) Loofah pretreatment: loofah is derived from loofah fruit, which is obtained by peeling and removing the core, cutting loofah into small pieces, washing with water, drying in vacuum, crushing, and sieving with a 60-mesh sieve;

[0033] (2) Alkali treatment of loofah: 50% of the total mass of loofah with pulverization, with a concentration of 5% NaOH solution and 20% ethanol solution to mix and immerse in azeotropic 2h, wash with deionized water after cooling until the pH is 7. After suction filtration, dry at 60°C to obtain alkalized loofah;

[0034] (3) Acylated loofah: In a stoppered conical flask, add 3.6g alkalized loofah and 25g chloroform, stir for 10min under the protection of argon, add 2.0g acryloyl chloride dropwise with a constant pressure funnel, Stir for 10 minutes after dropping, then add 3.0 mL of triethylamine dropwise with a constant pressure funnel, after the dropwise addition, stir at room temperature for 24 hours, filter, wash with chloroform and ...

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Abstract

The invention discloses a surface artemisinin molecule imprinting adsorbing material of a vegetable sponge. The material is characterized characterized by being prepared by the following steps of: preparing a polymer by selecting vegetable sponge as a substrate material, taking artemisinin as a template molecule, taking itaconic acid and acrylamide as functional monomers, taking ethylene glycol dimethacrylate as a cross-linking agent, taking azodiisobutyronitrile as an initiator and taking N,N-dimethylformamide as a solvent; and removing the artemisinin by using a hexane-diethyl ether mixed solution. The invention further provides a preparation method and an application method of the surface artemisinin molecule imprinting adsorbing material of the vegetable sponge. The surface artemisinin molecule imprinting adsorbing material of the vegetable sponge can separate the artemisinin with a structural analogue under normal pressure and temperature conditions; and the surface artemisinin molecule molecular imprinting adsorbing material of the vegetable sponge has the advantages of specificity, selectivity, good mechanical performance, good chemical stability, fast adsorbing speed, easiness for being eluted, biodegradability, simple process, regeneration capability, environmental friendliness and the like.

Description

technical field [0001] The invention relates to a preparation method and application technology of a molecular imprinted adsorption material, in particular to a preparation method of an artemisinin molecular imprinted adsorption material on the surface of loofah and its application technology in drug detection and purification. Background technique [0002] Artemisinin is a new type of sesquiterpene lactone containing peroxy bridge isolated from Artemisia annua. It has pharmacological activities such as antimalarial, antibacterial, antipyretic, and immune enhancement. It has low toxicity and no side effects. It is recommended by the World Health Organization drug of choice in the treatment of malaria. The detection and purification of active ingredients of artemisinin are very important to the quality of medicines. In terms of extraction and separation of natural medicines with very low active ingredients, supercritical CO has unique advantages. 2 Extraction is low in price...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J20/286B01J20/30B01D15/08C07D493/20
Inventor 李慧芝许崇娟陈亚明王志玲
Owner UNIV OF JINAN
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