Method for preparing protein ribonuclease protein crystal modified lead sulfide nanorod

A protein ribonucleic acid and ribonuclease technology, applied in the field of functional materials and drug treatment materials, can solve problems such as harsh reaction conditions and complex reaction steps, and achieve the effects of good biocompatibility, simple operation and mild conditions

Active Publication Date: 2012-07-25
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these methods generally require complex reaction steps and harsh reaction conditions, and generally the obtained nanomaterials are micron-scale

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Using water as a solvent, mix 5 ml of 0.1 mmol / L lead nitrate and 5 ml of 12.5 mg / L ribonuclease, adjust the pH to 5.5, and stir for 3 minutes at 25°C. Then add 5 milliliters of 0.1 mmol / L sodium sulfide, stir and react at 25 degrees Celsius for 5 minutes, then move this solution to a temperature-controllable microwave reactor, the microwave power is 100W, and carry out heating reaction, control temperature: 100 degrees Celsius, The heating time is 1 minute, and lead sulfide nanorods are obtained.

Embodiment 2

[0023] Using water as a solvent, mix 1 ml of 0.01 mmol / L lead nitrate and 5 ml of 12.5 mg / L ribonuclease, adjust the pH value to 8, and stir at 25 degrees Celsius for 30 minutes. Then add 1 milliliter of 0.01 mmol / L sulfurized acetamide, stir and react at 25 degrees Celsius for 5 minutes, then move the solution to a temperature-controllable microwave reactor with a microwave power of 500W for heating reaction, control temperature: 80 degrees Celsius , the heating time was 5 minutes, and lead sulfide nanorods were obtained.

Embodiment 3

[0025] Using water as a solvent, mix 5 ml of 0.05 mmol / L lead chlorate and 5 ml of 50 mg / L ribonuclease, adjust the pH to 12, and stir for 60 minutes at 25°C. Then add 5 milliliters of a mixture of 0.05 mmol / L thiourea and ammonium thioacetate, stir and react at 25 degrees Celsius for 5 minutes, then move the solution to a temperature-controllable microwave reactor with a microwave power of 250W for heating reaction , control the temperature: 90 degrees Celsius, and heat for 30 minutes to obtain lead sulfide nanorods.

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Abstract

The invention discloses a method for preparing a protein ribonuclease protein crystal modified lead sulfide nanorod. The method includes preparing chelation liquor at first; leading amino acid perssad in protein ribonuclease protein crystal to be in cross-linking bonding with semiconductor metal ions; adding a sulfur source; and using a protein crystal cluster as a framework, bonding free lead in a reaction system with sulfur ions so as to drive lead sulfide nano particles to continuously grow, and controlling the reaction temperature and time and the concentration of reactant so as to prepare the nanorod structure. A lead sulfide ball nano structure has an important effect for promoting various subjects and professions including photoelectric conversion, photocatalysis, slow release of medicine, gene vectors and the like. The method has the advantages of simplicity in operation, mild condition, low cost and environmental protection, the synthetic lead sulfide nanorod is water-soluble and stable and is fine in biocompatibility, and the method is a simple method for preparing functional nano materials.

Description

technical field [0001] The invention relates to a preparation method of protein ribonuclease protein crystal-modified lead sulfide nanorods, which belongs to functional materials and medical treatment materials. Background technique [0002] Semiconductor sulfide materials have been widely used in optical conductors, medical imaging, and solar cells due to their unique optical, electrical, and thermal properties. Although the preparation, size and shape control of semiconductor sulfides have always been the research difficulties, due to the incomparable nanoscale effects of nanomaterials compared with other material effects, such as larger specific surface area and larger stock displacement. The latest research shows that semiconductor quantum dots such as lead sulfide, silver sulfide and copper sulfide have good optical properties in the near-infrared band, and are an ideal material for biomedical imaging, as well as nano-semiconductor sulfide and titanium oxide. Nanoscale...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01G21/21B82B3/00B82Y40/00B82Y30/00
Inventor 崔大祥陈俊阮静孔毅飞
Owner SHANGHAI JIAO TONG UNIV
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