Drug composition for treating senile vaginitis and preparation method thereof

A composition and vaginitis technology, applied in the field of medicine, can solve the problems of not inhibiting ovulation, influence and the like, and achieve the effects of broad antibacterial spectrum, strong antibacterial activity and enhanced resistance

Inactive Publication Date: 2012-09-05
ZHUHAI COLLEGE OF JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, it has a feedback inhibitory effect on the hypothalamus and pituitary gland, but does not inhibit ovulation, and only has a significant impact on the corpus luteum energy

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] This embodiment is moxifloxacin hydrochloride / estriol compound suppository:

[0015] prescription

[0016] Moxifloxacin hydrochloride 140g, estriol 0.45g, lanolin 10g, semi-synthetic fatty acid glyceride 840g, Tween-80 10g, a total of 1000 pieces were prepared.

[0017] Preparation:

[0018] Heat and melt semi-synthetic fatty acid glycerides, lanolin, and Tween-80 in a water bath, add moxifloxacin hydrochloride solution, and estriol into the melted matrix, stir well, cool slightly, take out and pour into the coated liquid In the vaginal suppository mold of paraffin wax, release from the mold after solidification, pack, and obtain.

Embodiment 2

[0020] This embodiment is moxifloxacin hydrochloride / estriol compound suppository:

[0021] prescription:

[0022] Moxifloxacin hydrochloride 130g, estriol 0.4g, polyoxyethylene 40 stearate 400g, polyethylene glycol-4000 400g, polyethylene glycol-400 120g, Tween-80 10g, a total of 1000 pieces were prepared

[0023] Preparation:

[0024] Polyoxyethylene 40 stearate, polyethylene glycol 4000, polyethylene glycol 400, and Tween-80 were heated and melted in a water bath, then moxifloxacin hydrochloride and estriol were added to the melted matrix, fully Stir evenly, take it out and pour it into a vaginal suppository mold coated with liquid paraffin and cetyl alcohol, release it after solidification, and pack it.

Embodiment 3

[0026] The present embodiment is moxifloxacin hydrochloride / estriol compound gel:

[0027] prescription:

[0028] Moxifloxacin hydrochloride 2.5g, estriol 0.01g, carbomer 1.5g, propylene glycol 25ml, Span-85 0.7g, triethanolamine 2g, laurocaprolactone 0.6g

[0029] Preparation:

[0030] Dissolve moxifloxacin hydrochloride in an appropriate amount of purified water and set aside. Another mixture of carbomer, propylene glycol, laurocapram, Span-85 and an appropriate amount of water was uniformly mixed, and triethanolamine was added while stirring to obtain a gel matrix. Add moxifloxacin hydrochloride solution and estriol into the above matrix under stirring, mix evenly, add purified water to 1000ml, and stir evenly again to obtain the product.

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PUM

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Abstract

The invention provides a drug composition for treating senile vaginitis and a preparation method thereof. The drug composition takes estriol and moxifloxacin hydrochloride as the main active ingredients, is mainly used for treating such symptoms of senile vaginitis as vaginal wall atrophy, mucosa thinning, local resistance decrease and inflammations caused by bacteria invasion and reproduction and has the functions of recovering the activity of the vaginal epithelial cell and suppressing growth and reproduction of bacteria in the vagina. The drug composition is used for preferably preparing such dosage forms for intravaginal administration as suppositories, gels and ointments.

Description

technical field [0001] The present invention relates to the technical field of medicine, specifically a pharmaceutical composition for treating senile vaginitis and a preparation method thereof, as well as ointments, suppositories and gels made of the composition as effective medicinal ingredients Or other pharmaceutical preparations administered intravaginally. technical background [0002] Senile vaginitis is common in postmenopausal women. Due to ovarian function decline, estrogen level decreases, vaginal wall atrophy, mucous membrane becomes thinner, glycogen content in epithelial cells decreases, vaginal pH value increases, and local resistance decreases, leading to bacterial infection. Invasion and reproduction cause inflammation, and easily spread to the urinary system to cause urethritis, cystitis, and urinary incontinence, affecting the quality of life of postmenopausal women. [0003] Antibiotic systemic or local vaginal treatment can inhibit the growth and reprod...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/565A61P15/02A61P31/04A61K31/4709
Inventor 滕利荣江连海赵明智吴丽艳金元宝王艳珍王立英张瑶刘明石孟凡欣杨东生国程悦
Owner ZHUHAI COLLEGE OF JILIN UNIV
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