Chinese medicine composition for controlling metabolic diseases as well as preparation method and application thereof

A technology for metabolic diseases and compositions is applied in the field of traditional Chinese medicine compositions for preventing and treating metabolic diseases, and achieves the effects of inhibiting proliferation of fat cells, economical preparation process, and lowering blood lipids and blood sugar.

Inactive Publication Date: 2012-09-26
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In modern medical research, although there are clinical and experimental reports on the effects of Astragalus, Pueraria Radix, Morus alba and their extracts on treating diabetes, there is no research on the combination of three herb extracts to treat metabolic syndrome

Method used

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  • Chinese medicine composition for controlling metabolic diseases as well as preparation method and application thereof
  • Chinese medicine composition for controlling metabolic diseases as well as preparation method and application thereof
  • Chinese medicine composition for controlling metabolic diseases as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Take dried astragalus, kudzu root and mulberry bark, 600g each, crush them, divide them into three parts, use 50%, 75% and 95% ethanol by volume respectively, and the solid-liquid ratio is 1:6~1:10 (that is, 600g Add 3.6-6L of different volumes of ethanol to the medicinal material), heat and reflux 2-3 times, each time for 1-5 hours, combine the extracts, dry under reduced pressure to obtain the extracts, and the weights are 120g, 150g and 90g respectively.

Embodiment 2

[0035] Dried Astragalus membranaceus and Morus alba decoction pieces each 200g, kudzu root 400g, pulverized, add 5-8L of water to decoct for 1-5 hours, filter, repeat decoction 2-3 times, combine decoction with water, concentrate in appropriate amount to obtain decoction, or on this basis On the other hand, it is processed into oral liquid through ethanol precipitation, filtration and other processes.

[0036] The dosage form can take the following methods:

[0037] After the extracts are combined, add dextrin, spray dry to make fine powder, make powder or dry granulate into granules; or add sodium hydroxymethyl starch, micro silica gel, soluble starch, lactose, magnesium stearate, etc., mix Uniformly, make granules with 95% ethanol or compress into tablets after drying at 80°C; or add appropriate amount of micro-silica gel, mix well, and put into capsules to make capsules; or add citric acid and starch to some fine powders to make granules , adding sodium bicarbonate and sta...

Embodiment 3

[0039] 3.1 Purpose of the experiment: Study on the therapeutic effect of AMP-1915 on metabolic diseases in obese mice induced by high-fat diet

[0040] 3.2 Experimental method

[0041] 3.2.1 Preparation of animal models

[0042] After three months of induction with high-fat diet, fasting blood glucose and body weight of C57BL / 6 mice were significantly improved compared with the negative control group (fed with low-fat diet), which proved that the model was established successfully.

[0043] 3.2.2 Experimental grouping

[0044] 21 C57BL / 6 female mice were randomly divided into 3 groups according to body weight from the day of modeling, 7 mice in the negative control group (Chow), and 14 mice in the modeling group. Three months after modeling, the modeling group was randomly divided into positive model group (HF) and AMP-1915 drug treatment group (HF+AMP) with 7 rats in each group.

[0045] 3.2.3 Administration

[0046] AMP-1915 was mixed into high-fat feed at a certain dose...

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Abstract

The invention relates to a Chinese medicine composition for controlling metabolic diseases as well as a preparation method and application thereof, belongs to the technical field of traditional Chinese medicine, and in particular relates to a Chinese medicine composition prepared from astragalus membranaceus, kudzu vine root and white mulberry root-bark. The Chinese medicine composition has the effects of inhibiting adipocyte proliferation and reducing blood fat and blood sugar and can be applied to preparation of medicaments or health-care products for controlling the metabolic diseases.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for preventing and treating metabolic diseases, a preparation method and application of the composition, and belongs to the technical field of traditional Chinese medicine. Background technique [0002] Metabolic syndrome is a syndrome combined with hypertension and abnormal glucose and lipid metabolism. Accompanied by elevated low-density lipoprotein and low high-density lipoprotein cholesterol. Its common symptoms are obesity, diabetes, hyperlipidemia, and atherosclerosis. [0003] Hyperlipidemia includes hypercholesterolemia, hypertriglyceridemia, and compound hyperlipidemia in which both are high. High cholesterol leads to atherosclerosis, which in turn leads to coronary heart disease and stroke; while hypertriglyceridemia is closely related to the occurrence of obesity, fatty liver and type II diabetes. [0004] The initial cause of metabolic syndrome is obesity and weight gain...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/605A61P3/04A61P3/06A61P9/10
Inventor 黄诚范圣洁陆雄刘改改郭露张玉张璐顾明
Owner SHANGHAI UNIV OF T C M
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