Multiple emulsion of arbutin and preparation method thereof

A technology of multiple emulsions and arbutin, which is applied in the directions of pharmaceutical formulations, cosmetic preparations, toiletry preparations, etc., can solve the problems of arbutin's poor stability and low bioavailability, and achieve improved drug loading and preparation methods. Simple, good compatibility effect

Inactive Publication Date: 2012-10-03
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Technical problem: the object of the present invention is to provide a kind of arbutin multiple emulsion with high stability and good compatibility, which solves the problems of poor arbutin stability and low bioavailability in the prior art

Method used

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  • Multiple emulsion of arbutin and preparation method thereof
  • Multiple emulsion of arbutin and preparation method thereof
  • Multiple emulsion of arbutin and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] The preparation of embodiment 1 arbutin multiple emulsion

[0041] Composition formula

[0042]

[0043] Such as figure 1 Shown, the preparation steps of this embodiment are as follows:

[0044] 1. Weigh 4.0 grams of glyceryl monostearate, 10.0 grams of soybean lecithin, and 26.0 grams of Camellia oleifera seed oil into a beaker, and heat in a water bath at 65°C.

[0045] 2. Weigh 0.5 grams of arbutin, put 39.5 grams of deionized water into a beaker, and heat it in a water bath at 50°C as the inner water phase;

[0046] 3. Weigh 0.8 g of sucrose ester, put 39.2 g of deionized water into a beaker, and heat in a water bath at 65° C. as the external water phase.

[0047] 4. Add the inner water phase to the oil phase and stir evenly. At the same time, turn on the high-pressure homogenizer and preheat it with deionized water at 65°C;

[0048] 5. Inject the uniformly stirred high-temperature emulsion system into a high-pressure homogenizer, adjust the homogenization pr...

Embodiment 2

[0050] The preparation of embodiment 2 arbutin multiple emulsions

[0051] Composition formula

[0052]

[0053] Preparation steps:

[0054] 1. Weigh 4.0 grams of glyceryl monostearate, 10.0 grams of soybean lecithin, and 26.0 grams of aloe vera oil into a beaker, and heat in a water bath at 55°C;

[0055] 2. Weigh 0.5 grams of arbutin, put 39.5 grams of deionized water into a beaker, and heat it in a water bath at 50°C as the inner water phase;

[0056] 3. Weigh 0.8 g of sucrose ester, put 39.2 g of deionized water into a beaker, and heat in a water bath at 55°C as the external water phase;

[0057] 4. Add the inner water phase to the oil phase, stir evenly, and shear. At the same time, turn on the high-pressure homogenizer and preheat it with 55°C deionized water;

[0058] 5. Inject the uniformly stirred high-temperature emulsion system into the high-pressure homogenizer, adjust the homogenization pressure to 50MPa, and the flow rate to 42dm 3 / h, homogenize for 1min ...

Embodiment 3

[0060] The preparation of embodiment 3 arbutin multiple emulsions

[0061] Composition formula

[0062]

[0063]

[0064] Preparation steps:

[0065] 1. Weigh 4.0 grams of glyceryl monostearate, 10.0 grams of soybean lecithin, and 26.0 grams of soybean oil into a beaker, and heat in a water bath at 70°C;

[0066] 2. Weigh 0.5 grams of arbutin, put 39.5 grams of deionized water into a beaker, and heat it in a water bath at 50°C as the inner water phase;

[0067] 3. Weigh 0.8 g of sucrose ester, put 39.2 g of deionized water into a beaker, and heat in a water bath at 70°C as the external water phase;

[0068] 4. Add the inner water phase to the oil phase, stir evenly, and shear. At the same time, turn on the high-pressure homogenizer and preheat it with 70°C deionized water;

[0069] 5. Inject the uniformly stirred high-temperature emulsion system into the high-pressure homogenizer, adjust the homogenization pressure to 50MPa, and the flow rate to 42dm 3 / h, homogenize...

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Abstract

The invention discloses multiple emulsion of arbutin. The carrier is loaded with active components of the arbutin. The multiple emulsion is characterized by comprising the following components in percent by weight: 0.5-2% of arbutin, 0.5-2% of hydrophilic emulsifier, 8-15% of lipophilic emulsifier, 25-40% of composite lipid material and the balance of deionized water, wherein the composite lipid material is mixture of a solid lipid material and a liquid lipid material; the lipid material is at least one of the compounds: glycerin monostearate, oil-tea camellia seed oil, aloe oil, macadamia nut oil, avocado oil, acetylated monoglyceride, caprylic capric triglyceride, canola oil, sunflower seed oil and soybean oil. The multiple emulsion disclosed by the invention has good stability and water solubility; and the preparation method is simple and controllable, is good in repeatability and can be applied to preparation of cosmetics containing the arbutin.

Description

technical field [0001] The invention belongs to the technical field of carrier systems in cosmetic preparation technology, and relates to a nanoscale carrier and a preparation method thereof, in particular to a multiple emulsion with arbutin as an active ingredient and a preparation method thereof. Background technique [0002] Arbutin is white needle-like crystal or powder, and has two different phase isomers, namely α and β types, and the chemical names are 4-hydroxybenzene-α-D-glucopyranoside and 4-hydroxybenzene-β —D-glucopyranoside. Arbutin is easily soluble in hot water, methanol, ethanol, propylene glycol, and glycerol aqueous solution, but insoluble in ether, chloroform, petroleum ether, etc., with a melting point of 198-201°C. It is a naturally occurring chemical that was first found in the leaves of plants of the Bearberry genus. This genus is mainly distributed in Western Europe and North America, and there is no report on its distribution in China. Later studi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/92A61K8/60A61K8/06A61Q19/00A61Q19/02
Inventor 夏强陈衍玲
Owner SOUTHEAST UNIV
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