Enrofloxacin injection for livestock and preparation method thereof
A technology of enrofloxacin and injection, applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, organic active ingredients, etc., can solve the problems of production crystallization, increased drug residues, limited solubility, etc., and achieve frost resistance Good, less adverse reactions, strong efficacy
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[0041] Example 1: Preparation of 2.5m / v% (g / mL) veterinary enrofloxacin injection
[0042] A kind of enrofloxacin injection for veterinary use, the formula of this injection per 100mL is as follows:
[0043] Enrofloxacin 2.5g,
[0044] Artesunate 0.25g,
[0045] Trimethoprim 0.5g,
[0046] Flunixin meglumine 0.125g,
[0047] L-arginine 5g,
[0048] 0.1g sodium sulfite,
[0049] Sodium ethylenediaminetetraacetate 0.01g,
[0050] Propylene glycol 10mL,
[0051] 5mL of ethanol,
[0052] Add water for injection to 100 mL.
[0053] The veterinary enrofloxacin injection of the above formula is prepared according to the following steps:
[0054] 1) Add L-arginine to 20 mL of water for injection, heat to 55°C to dissolve, add enrofloxacin after dissolution, and stir to obtain liquid A.
[0055] 2) Dissolve sodium sulfite and sodium ethylenediaminetetraacetate in 5mL water for injection under stirring to obtain liquid B.
[0056] 3) Heat propylene glycol to 80°C, add trimethoprim, and after the dissolutio...
Example Embodiment
[0060] Example 2: Preparation of 5m / v% (g / mL) veterinary enrofloxacin injection
[0061] A kind of enrofloxacin injection for veterinary use, the formula of this injection per 100mL is as follows:
[0062] Enrofloxacin 5g,
[0063] Artesunate 0.5g,
[0064] Trimethoprim 1g,
[0065] Flunixin meglumine 0.25g,
[0066] L-arginine 8g,
[0067] Sodium thiosulfate 0.2g,
[0068] Sodium ethylenediaminetetraacetate 0.02g,
[0069] Propylene glycol 20mL,
[0070] 15mL of ethanol,
[0071] Add water for injection to 100 mL.
[0072] The preparation steps of the injection are the same as in Example 1.
Example Embodiment
[0073] Example 3: Preparation of 7.5m / v% (g / mL) veterinary enrofloxacin injection
[0074] A kind of enrofloxacin injection for veterinary use, the formula of this injection per 100mL is as follows:
[0075] Enrofloxacin 7.5g,
[0076] Artesunate 0.75g,
[0077] Trimethoprim 1.5g,
[0078] Flunixin meglumine 0.375g,
[0079] L-Arginine 9g
[0080] Sodium thiosulfate 0.25g,
[0081] Sodium ethylenediaminetetraacetate 0.03g,
[0082] Propylene glycol 25mL,
[0083] 15mL of ethanol,
[0084] Add water for injection to 100 mL.
[0085] The preparation steps of the injection are the same as in Example 1.
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