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Enrofloxacin injection for livestock and preparation method thereof

A technology of enrofloxacin and injection, applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, organic active ingredients, etc., can solve the problems of production crystallization, increased drug residues, limited solubility, etc., and achieve frost resistance Good, less adverse reactions, strong efficacy

Active Publication Date: 2012-10-03
武汉回盛生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the limited solubility of enrofloxacin in alkaline solution, problems such as crystallization and poor frost resistance are prone to occur in production, so it will be more difficult to challenge high concentrations
In addition, quinolones are widely distributed in the body. In order to achieve an effective therapeutic effect, the dose of the drug should be increased, which will easily cause the increase of the drug residue in other tissues and produce some toxic and side effects.

Method used

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  • Enrofloxacin injection for livestock and preparation method thereof
  • Enrofloxacin injection for livestock and preparation method thereof
  • Enrofloxacin injection for livestock and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Example 1: Preparation of 2.5m / v% (g / mL) Enrofloxacin Injection for Veterinary Use

[0042] A kind of veterinary enrofloxacin injection, the formula of every 100mL of this injection is as follows:

[0043] Enrofloxacin 2.5g,

[0044] Artesunate 0.25g,

[0045] Trimethoprim 0.5g,

[0046] Flunixin meglumine 0.125g,

[0047] L-Arginine 5g,

[0048] Sodium sulfite 0.1g,

[0049] Sodium edetate 0.01g,

[0050] Propylene glycol 10mL,

[0051] Ethanol 5mL,

[0052] Add water for injection to 100mL.

[0053] The veterinary enrofloxacin injection of the above formula is prepared according to the following steps:

[0054] 1) Add L-arginine to 20mL of water for injection, heat to 55°C to dissolve, add enrofloxacin after dissolution and stir evenly to obtain liquid A.

[0055] 2) Sodium sulfite and sodium edetate were dissolved in 5 mL of water for injection under stirring to obtain liquid B.

[0056] 3) Heat the propylene glycol to 80°C, add trimethoprim, after the dis...

Embodiment 2

[0060] Example 2: Preparation of 5m / v% (g / mL) Enrofloxacin Injection for Veterinary Use

[0061] A kind of veterinary enrofloxacin injection, the formula of every 100mL of this injection is as follows:

[0062] Enrofloxacin 5g,

[0063] Artesunate 0.5g,

[0064] Trimethoprim 1g,

[0065] Flunixin meglumine 0.25g,

[0066] L-Arginine 8g,

[0067] Sodium thiosulfate 0.2g,

[0068] Sodium edetate 0.02g,

[0069] Propylene glycol 20mL,

[0070] Ethanol 15mL,

[0071] Add water for injection to 100mL.

[0072] The preparation steps of the injection are the same as in Example 1.

Embodiment 3

[0073] Example 3: Preparation of 7.5m / v% (g / mL) Enrofloxacin Injection for Veterinary Use

[0074] A kind of veterinary enrofloxacin injection, the formula of every 100mL of this injection is as follows:

[0075] Enrofloxacin 7.5g,

[0076] Artesunate 0.75g,

[0077] Trimethoprim 1.5g,

[0078] Flunixin meglumine 0.375g,

[0079] L-Arginine 9g

[0080] Sodium thiosulfate 0.25g,

[0081] Sodium edetate 0.03g,

[0082] Propylene glycol 25mL,

[0083] Ethanol 15mL,

[0084] Add water for injection to 100mL.

[0085] The preparation steps of the injection are the same as in Example 1.

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Abstract

The invention relates to the technical field of a pharmaceutical preparation for livestock and specifically discloses an enrofloxacin injection for the livestock and a preparation method thereof. The raw material of the injection is composed of enrofloxacin, artesunate, trimethoprim, flunixin meglumine, L-arginine, antioxidant, chelant, compound organic solvent and water for injection. The enrofloxacin injection for the livestock can effectively enhance the antibacterial effect of the drug, has an excellent anti-inflammatory effect and is mainly used for treating serious mixed infection caused by sensitive bacteria and mycoplasma of the livestock; the generation of drug resistance is effectively reduced; and the toxic and side effects are reduced. The preparation method for the enrofloxacin injection for the livestock provided by the invention is simple, low-cost, high in stability, convenient in use, and suitable for industrial production.

Description

technical field [0001] The invention relates to the technical field of veterinary pharmaceutical preparations, in particular to a veterinary enrofloxacin injection and a preparation method of the injection. Background technique [0002] Enrofloxacin is a third-generation fluoroquinolone broad-spectrum antibacterial drug specially used for animals. It has a broad-spectrum bactericidal effect and can kill Gram-negative bacilli, cocci, positive bacteria, mycoplasma, and chlamydia. It is effective for both quiescent and growing bacteria. Sensitive bacteria die within 20-30 minutes after contact with this product. It has strong bactericidal activity, high efficiency and low toxicity. It is mainly used clinically to treat enteritis, pneumonia, mastitis and soft tissue infectious diseases caused by livestock and poultry bacteria and mycoplasma. [0003] Meinen et al. (1995) showed that the bactericidal effect of enrofloxacin is concentration-dependent. In tissues and plasma, the ...

Claims

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Application Information

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IPC IPC(8): A61K31/505A61K31/496A61K31/357A61K31/44A61K9/08A61P31/04A61P29/00A61P33/02
Inventor 张卫元张永丹操继跃陈翠兰肖飞周瑜刘国庆
Owner 武汉回盛生物科技股份有限公司
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