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Degradable absorptive poly lactic-co-glycolic acid (PLGA)-Mg series composite medical implant and preparation method thereof

A composite material, PLGA technology, applied in the field of biodegradable absorbable PLGA-Mg composite medical implants and its preparation, to achieve the effects of reducing corrosion rate, promoting adhesion and growth, and delaying degradation

Inactive Publication Date: 2012-11-07
郑玉峰 +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, magnesium will form calcium and phosphate deposits on the surface of the composite during the degradation process, which can promote the adhesion and growth of bone cells to a certain extent, and solve the above-mentioned problems existing in the existing degradable and absorbable biomedical metal materials.

Method used

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  • Degradable absorptive poly lactic-co-glycolic acid (PLGA)-Mg series composite medical implant and preparation method thereof
  • Degradable absorptive poly lactic-co-glycolic acid (PLGA)-Mg series composite medical implant and preparation method thereof
  • Degradable absorptive poly lactic-co-glycolic acid (PLGA)-Mg series composite medical implant and preparation method thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0029] The steps of the preparation method of the medical degradable and absorbable PLGA-Mg composite material implant of the present invention are as follows:

[0030] Step 1: Dissolve the polymer PLGA in dichloromethane at a mass volume ratio of 1:10. After the polymer PLGA is completely dissolved, add 0.5 to 4% magnesium wire according to the weight percentage of the polymer PLGA, and mechanically Stir well;

[0031] Step 2: At room temperature, after 2 / 3 of the dichloromethane volatilizes, pour the polymer PLGA solution on a polytetrafluoroethylene sheet, let the dichloromethane completely volatilize, and obtain PLGA-Mg on the polytetrafluoroethylene sheet Composite material sheet, remove the PLGA-Mg composite material sheet;

[0032] Step 3: Machining to make a dense structure PLGA-Mg system composite degradable material implant;

[0033] The mechanical processing method is hot pressing, and the hot pressing is to keep the PLGA-Mg composite material sheet obtained in st...

Embodiment 1

[0036] Dissolve PLGA in dichloromethane at a mass volume ratio of 1:10, and then divide it into two parts, and then add 2% and 4% magnesium with a length of 3mm to the two parts of the solution according to the weight percentage of the polymer PLGA. After the dichloromethane volatilizes 2 / 3, then pour the two mixed solutions with a certain viscosity on the polytetrafluoroethylene board, and after the mixed solvent is completely volatilized, remove the two parts from the polytetrafluoroethylene board. Composite material film, then preheat the two composite material films obtained above at 140°C for 15 minutes, after preheating, press at 20MPa and 120°C for 10 minutes to form two blanks, and wait for the blanks to be heated at room temperature PLGA-Mg composites were obtained after natural cooling

Embodiment 2

[0038] Two pieces of composite materials obtained in Example 1 are cut into width 2mm, length 40mm, thin sheet of thickness 1mm, carry out tensile test under room temperature condition, adopt 0.5mm / min tensile rate to stretch, obtain such as figure 1 The tensile property curve of the PLGA-Mg composite material at room temperature is shown.

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Abstract

The invention provides a medical degradable absorptive poly lactic-co-glycolic acid (PLGA)-Mg series composite implant, which comprises the following components in percentage by weight: 0.5 to 4 percent of magnesium wire (Mg), the balance of PLGA, and one or more of aluminum (Al), zinc (Zn) and manganese (Mn), wherein the main component of the magnesium wire is magnesium; and the PLGA-Mg series composite implant has a compact structure, is a therapeutic bone repair instrument, and is used for preparing bone tissue repair scaffolds, bone connectors, fixing screws, fixing rivets, bone clamping plates and the like. The invention also provides a preparation method for the composite implant. A macromolecular coverage layer is formed on the surface of the magnesium wire by compounding the magnesium wire and the PLGA, so that the corrosion rate of magnesium is reduced, and degradation of the magnesium is delayed; high mechanical strength is provided for the medical implant by the PLGA series composite material; and sediment of calcium and phosphorus salts is formed on the surface of the compound in the degradation process of the magnesium, so that adhesion and growth of bone cells can be promoted to a certain degree.

Description

technical field [0001] The invention belongs to the technical field of medical devices, and relates to the design of a PLGA-Mg composite material suitable as a degradable orthopedic implant device, in particular to a non-toxic, good tissue compatibility, mechanical properties and degradation rate degradable The invention discloses a degradable and absorbable PLGA-Mg composite material medical implant and a preparation method thereof. Background technique [0002] At present, biodegradable materials for medical use are mainly degradable polymer materials, which mainly include polylactic acid (PLA), polyglycolic acid (PGA), polycaprolactone (PCL) and their copolymers, natural polysaccharide materials (fiber protein, chitin) and natural protein materials (collagen, fibrin), etc. Although degradable polymer materials can be completely absorbed by the human body, they have low strength and poor mechanical properties, making it difficult to provide structural support. In additio...

Claims

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Application Information

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IPC IPC(8): A61L27/44A61L31/12
Inventor 郑玉峰吴远浩李楠李扬德李卫荣
Owner 郑玉峰
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