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Method for preparing melamine-formaldehyde resin fluorescent microspheres

A technology of melamine and fluorescent microspheres, which is applied in the preparation of microspheres, microcapsule preparations, chemical instruments and methods, etc., can solve the problems of uniformity reduction of microspheres, limitation of dye types, restrictions, etc., and achieve good monodispersity effect

Inactive Publication Date: 2012-11-28
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this reaction requires fluorescent molecules with special reactive groups, which limits the types of dyes, and because the fluorescent molecules are connected to the polymerized monomer, the uniformity of the microspheres obtained by polymerization decreases, thus limiting the use of this method.

Method used

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  • Method for preparing melamine-formaldehyde resin fluorescent microspheres
  • Method for preparing melamine-formaldehyde resin fluorescent microspheres
  • Method for preparing melamine-formaldehyde resin fluorescent microspheres

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Prepare fluorescein-melamine-formaldehyde resin fluorescent microspheres, comprising the following steps:

[0022] Step 1. Mix 2.6 g of melamine and 11 g of formaldehyde solution with a mass percent concentration of 40%, add 0.1 mol / L nitric acid solution, adjust the pH to 4, and stir and react at 80°C to prepare a soluble prepolymer of melamine-formaldehyde solution;

[0023] Step 2, adding fluorescent dye fluorescein to the prepolymer solution obtained in step 1, the mass ratio of the added fluorescent dye to melamine is 1.5:100, the dye molecules are adsorbed and wrapped inside the branched prepolymer molecules, Obtain the prepolymer solution that encapsulates the dye;

[0024] Step 3, mixing the dyed prepolymer solution obtained in step 2 with deionized water, the ratio of deionized water to melamine is 10:0.3 by mass ratio, adding 0.1mol / L sodium hydroxide solution to adjust the pH of the system to be 6 , and reacted at 80°C for 40 minutes. During this process, i...

Embodiment 2

[0028] Prepare coumarin 30-melamine-formaldehyde resin fluorescent microspheres, comprising the following steps:

[0029] Step 1. Mix 2.6 g of melamine and 5.2 g of formaldehyde solution with a mass percent concentration of 40%, add 0.1 mol / L nitric acid solution, adjust the pH to 6, and stir and react at 20°C to prepare a soluble prepolymer of melamine-formaldehyde substance solution;

[0030] Step 2. Add fluorescent dye coumarin 30 dye powder to the prepolymer solution obtained in step 1. The mass ratio of the added fluorescent dye to melamine is 1:100. The dye molecules are adsorbed and wrapped in the branched prepolymer solution. Inside the molecule, the prepolymer solution wrapped with the dye is obtained;

[0031] Step 3, mixing the dyed prepolymer solution obtained in step 2 with deionized water, the ratio of deionized water to melamine is 10:0.4 by mass ratio, adding 0.1mol / L nitric acid solution to adjust the pH of the system to be 2, and then React at 90°C for 40 m...

Embodiment 3

[0034] The preparation of acridine orange-melamine-formaldehyde resin fluorescent microspheres includes the following steps:

[0035] Step 1. Mix 2.6 g of melamine and 11 g of formaldehyde solution with a mass percentage concentration of 40%, add 0.1 mol / L sodium hydroxide solution, adjust the pH to 9, and stir the reaction at 50 ° C to prepare the soluble pre-melamine-formaldehyde solution. polymer solution;

[0036] Step 2: Add the fluorescent dye acridine orange dye powder into the prepolymer solution obtained in step 1, and the mass ratio of the added fluorescent dye to the mass of melamine is 0.5:100, and the dye molecules are adsorbed and wrapped in the branched prepolymer. Inside the molecule, the prepolymer solution encapsulated with the dye is obtained;

[0037] Step 3: Mix the dyed prepolymer solution obtained in step 2 with deionized water, the ratio of deionized water to melamine is 10:0.3 by mass ratio, add 0.1mol / L nitric acid solution to adjust the pH of the sy...

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Abstract

The invention discloses a method for preparing melamine-formaldehyde resin fluorescent microspheres. The method comprises the following steps of: preparing soluble melamine-formaldehyde prepolymer by using melamine and formaldehyde as raw materials; adding fluorochrome into the prepared prepolymer solution, and adsorbing fluorochrome molecules to wrap the branched prepolymer molecules; and heating to perform further intramolecular and intermolecular polycondensation on the prepolymer to obtain monodisperse fluorescent microspheres of which the particle size can be controlled and which can wrap various fluorochromes. The fluorescent microspheres prepared by the method have the characteristics of stable fluorescence property, organic solvent resistance, high temperature resistance and the like, and have wide application prospect in the fields of tissue marking, immunological detection, correction of fluorescence optical equipment and the like.

Description

technical field [0001] The invention relates to a preparation method of polymer material fluorescent microspheres, in particular to a preparation method of melamine-formaldehyde resin fluorescent microspheres. Background technique [0002] Fluorescent microspheres refer to solid particles with diameters ranging from nanometers to micrometers, loaded with fluorescent substances, and excited by external energy to fluoresce. Due to the large specific surface area, strong adsorption, strong surface reaction ability and stable and efficient luminous efficiency of fluorescent microspheres, the application in the field of biology has attracted more and more attention. In recent years, with the in-depth study of fluorescent probe technology, people have been able to prepare a variety of fluorescent microspheres with particle sizes ranging from nanometers to micrometers. [0003] At present, there are mainly the following methods for preparing fluorescent microspheres with fluoresce...

Claims

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Application Information

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IPC IPC(8): C09K11/06B01J13/14
Inventor 吴道澄李艳秦雷杨飞龙吴宥伸
Owner XI AN JIAOTONG UNIV
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