Temperature response type injectable hydrogel and preparation method and usage thereof

A temperature-responsive, water-for-injection technology, applied in pharmaceutical formulations, medical preparations of non-active ingredients, prostheses, etc., can solve the problems of complex production process, poor controllability of gel properties, and difficult purification, and achieve the goal of preparing The effect of simple process

Inactive Publication Date: 2012-12-19
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This type of gel can also undergo sol-gel transformation after injection, but the production proce...

Method used

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  • Temperature response type injectable hydrogel and preparation method and usage thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Step 1: Select polyethylene glycol 2000 as the hydrophilic segment, and use succinic anhydride as the cross-linking agent to carboxylic acid, chlorination and secondary esterification of cholesterol to obtain cholesterol-polyethylene glycol-2000-cholesterol. Namely component A.

[0040] Step 2: Oxidize dextran with a molecular weight of 40 kDa in an aqueous solution of periodic acid with a molar ratio of 20% periodic acid / sugar ring, and dialyze with deionized water until the final conductivity of the dialysis medium is less than 1 μS / cm Then, the product obtained after freeze-drying and the aminated β-cyclodextrin in aqueous solution 30-50 o After the reaction is completed at C, it is dialyzed again until the final conductivity of the dialysis medium is lower than 1 μS / cm and then freeze-dried. The content of β-cyclodextrin measured by phenolphthalein probe method is 0.5-0.6g / g, which is component B.

[0041] Step 3: According to the mass ratio of component A and component...

Embodiment 2

[0043] Cholesterol-polyethylene glycol-2000-cholesterol was prepared according to the method in step one and step two of Example 1, that is, β-cyclodextrin with the content of component A and β-cyclodextrin of 0.5-0.6g / g Fine grafted aldehyde dextran, component B.

[0044] According to the mass ratio of component A and component B as component A / component B=7 / 3, the sum of the mass of component A and component B is 20% of the total mass, and weigh component A, component B, Water: Mix component A and component B with water to swell to obtain a stable gel, which has certain strength and self-repairing properties, and has a slow release effect on hydrophilic and protein drugs.

Embodiment 3

[0046] Cholesterol-polyethylene glycol-2000-cholesterol was prepared according to the method in step one and step two of Example 1, that is, β-cyclodextrin with the content of component A and β-cyclodextrin of 0.5-0.6g / g Fine grafted aldehyde dextran, component B.

[0047] According to the mass ratio of component A and component B as component A / component B = 1 / 1, the sum of the mass of component A and component B is 20% of the total mass, and weigh component A, component B, Water: Mix component A and component B with water to swell to obtain a stable gel, which has certain strength, injectability and self-repair, and has a sustained release effect on hydrophilic and protein drugs.

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Abstract

The invention relates to a temperature response type injectable hydrogel and a preparation method and the usage of the injectable hydrogel; the hydrogel comprises component A, component B and water, wherein the component A is cholesterol-polyethylene glycol-cholesterol; and the component B is amination beta cyclodextrin graft hydroformylation glucan. The preparation process of the injectable hydrogel is simple and convenient, and the prepared injectable hydrogel has a certain strength and toughness as well as self-repairability; compared with the prior art, the invention improves the controllability of the performances of the hydrogel, and further improves the biocompatibility of the hydrogel; the hydrogel prepared by the invention has biodegradability and can be etabolized by human body; and the hydrogel has temperature responsiveness and injectability, and can be used for a drug carrier, embolism material and tissue engineering material.

Description

technical field [0001] The invention relates to polymer materials, in particular to a temperature-responsive injectable hydrogel and its preparation method and application. Background technique [0002] Hydrogels are aggregates with a three-dimensional network structure formed by cross-linking hydrophilic polymers. Although it is insoluble in water, the hydrophilic part of this aggregate can bind a large amount of water, so that the entire gel swells. Such high water retention properties and flexible characteristics make the structure of the hydrogel very similar to that of human tissue. Hydrogel materials are easy to modify, synthesize, and adjust properties. Ordinary hydrogels can be loaded with a large amount of water-soluble drugs, and after modification, they can also have good retention properties for oil-soluble drugs, and are more capable of loading Living cells or tissues that serve as scaffolding for growth. [0003] In situ hydrogel means that the gel is admini...

Claims

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Application Information

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IPC IPC(8): C08L51/02C08L71/08C08J3/075C08G65/48C08B37/02A61K47/40A61K47/36A61K9/06A61L31/06A61L31/04A61L31/14A61L27/26A61L27/52
Inventor 刘芝兰别拓铭刘佳程序王若郦王磊张留杰卓仁禧
Owner WUHAN UNIV
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