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Synthesizing method of cocoyl amino acid sodium

A technology of cocoyl amino acid sodium and a synthetic method, which is applied in the synthesis of cocoyl amino acid sodium prepared from cocoyl chloride, the synthesis field of cocoyl amino acid sodium, can solve environmental pollution, cannot meet the requirements of high-end market product quality, Problems affecting the application performance of high-end surfactants, etc., to achieve high reaction yield, good product quality, and no three wastes

Inactive Publication Date: 2013-01-09
CHANGSHA PUJI BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Contain more by-product phosphoric acid in the acyl chloride that phosphorus oxychloride method obtains, contain more sulfide in the acyl chloride that thionyl chloride method obtains, residual phosphorus, sulfur in the cocoyl amino acid sodium produced by it, will Affects the application performance of high-end surfactants and cannot meet the product quality requirements of the high-end market
At the same time, phosphorus trichloride is used as a chlorination reagent to produce a large amount of phosphorus-containing wastewater, and the sulfur dioxide produced by the thionyl chloride process has serious environmental pollution.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] In a 500mL four-neck flask equipped with a thermometer, a reflux condenser, an air duct, and agitation, add 284g (1mol) of coconut oil and 1.5g (0.02mol) of N,N-dimethylformamide, and heat up to 60°C. Control the reaction temperature to 70-80°C, within 5-10 hours, feed 110g (1.1mol) of phosgene, after the reaction is completed, vacuum distill, collect fractions at 160-200°C (533Pa) to obtain 262g of cocoyl chloride, with a yield of 87 %.

[0019] In a 1000mL four-necked flask equipped with a thermometer, a dropping funnel, and stirring, add 191g (1mol) of sodium glutamate, dissolve it in 570g of water, stir at room temperature to dissolve it completely, and make a 25% aqueous solution. Put 331g (1.1mol) of acid chloride into a dry dropping funnel, control the temperature in an ice-water bath at 20-25°C, add cocoyl chloride under stirring, and add 25% aqueous sodium hydroxide solution dropwise at the same time to keep the reaction solution constant At pH = 8 ~ 10, until...

Embodiment 2

[0021] Cocoyl chloride is synthesized with embodiment 1.

[0022] In a 1000mL four-neck flask equipped with a thermometer, a dropping funnel, and stirring, add 111g (1mol) of sodium sarcosinate, dissolve it in 333g of water, stir at room temperature to dissolve it completely, and then make a 25% aqueous solution, and add coconut oil Put 331g (1.1mol) of acid chloride into a dry dropping funnel, control the temperature in an ice-water bath at 15-20°C, add cocoyl chloride under stirring, and drop 25% aqueous sodium hydroxide solution at the same time to keep the reaction solution constant At pH = 8 ~ 10, until the addition is complete; continue to react for 4 ~ 5 h. After the reaction, cool at -5 to 5°C to precipitate crystals, filter with suction, and dry to obtain 342 g of sodium cocoyl sarcosinate with a yield of 91%.

Embodiment 3

[0024] Cocoyl chloride is synthesized with embodiment 1.

[0025] In a 1000mL four-neck flask equipped with a thermometer, a dropping funnel, and stirring, add 97g (1mol) of sodium glycinate, dissolve it in 291g of water, stir it at room temperature to dissolve it completely, and make a 25% aqueous solution. Add 331g of cocoyl chloride (1.1mol) into a dry dropping funnel, control the temperature in an ice-water bath at 15-20°C, add cocoyl chloride under stirring, and at the same time add 25% aqueous sodium hydroxide solution dropwise to keep the reaction solution at pH = 8 ~ 10, until the addition is complete; continue to react for 4 ~ 5 h. After the reaction, cool at 0-5°C to precipitate crystals, filter with suction, and dry to obtain 322 g of sodium cocoyl glycinate with a yield of 89%.

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Abstract

The invention relates to a synthesizing method of cocoyl amino acid sodium. The synthesizing method of the cocoyl amino acid sodium comprises the following steps of: taking cocinic acid and phosgene as raw materials, reacting the cocinic acid and the phosgene for 1-20 hours at a temperature of 60-100 DEG C at the presence of an organic amide catalyst, distilling reaction products in an vacuum environment after the reaction to obtain acyl chloride, and dropping the oleoyl chloride obtained through the phosgenation into amino acid sodium solution for reaction, wherein the pH value is controlled to 8-10, the reaction temperature is 15-20 DEG C, and the reaction time is 4-5 hours. The synthesizing method of the cocoyl amino acid sodium provided by the invention has the advantages of reasonable process, high reaction yield, high product quality, substantially no three wastes, no residual phosphorus and sulfur in the product, capability of being widely applied to the production of high-end surfactant, higher practical value as well as higher social and economical benefits.

Description

technical field [0001] The invention relates to a synthetic method of sodium cocoyl amino acid in the field of surfactants, in particular to a synthetic method for preparing sodium cocoyl amino acid from cocoyl chloride synthesized by a phosgene method. Background technique [0002] Sodium cocoyl amino acid is a kind of amino acid type anionic surfactant. Because of its excellent surface activity, low irritation and low toxicity, it is widely used in low irritation detergents, cosmetics, toothpaste and food, and can also be used in silk Dyeing and finishing, anti-rust additives, metal processing, mineral flotation and oil extraction and other industries. Its surface tension and wettability are similar to those of the penetrant JFC (polyoxyethylene ether); the foam power is better than that of sodium lauryl sulfate, a foaming agent commonly used in toothpaste. It has anti-caries properties; it has wide compatibility with other ingredients, which is lacking in other existing ...

Claims

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Application Information

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IPC IPC(8): C07C233/47C07C231/02
Inventor 李耀莲
Owner CHANGSHA PUJI BIOTECH
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