Process method for synthesizing medical biodegradable polylactic acid by performing polycondensation on lactic acid through catalysis of 1,5,7-triazabicyclo[4.4.0]decane-5-ene (TBD)

A technology for catalyzing lactic acid and biodegradation, applied in the field of drug degradation materials, can solve problems such as potential safety hazards, and achieve the effects of short time, easy industrialization and low cost of raw materials
CN102875779AInactive Publication Date: 2013-01-16NANJING UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
NANJING UNIV
Publication Date
2013-01-16
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a method for synthesizing medical biodegradable polylactic acid by directly performing polycondensation on lactic acid through catalysis of 1,5,7-triazabicyclo[4.4.0]decane-5-ene (TBD). According to the method, the polylactic acid product which is high in biosecurity is obtained by taking the TBD as a catalyst, and an industrial grade lactic acid aqueous solution of which the mass content is 90 percent as monomers, and by solvent-free (body) and two-stage condensation polymerization. According to the method, a tin catalyst which has cytotoxicity is eliminated, and the used catalyst has biocompatibility and biosecurity; the synthesized polylactic acid does not contain any metal and other toxic component and is suitable for medical and medicinal fields; the environment-friendly biodegradable polylactic acid is synthesized by an environment-friendly process (in which any reagent is not used and any toxic product is not generated) by using the environment-friendly catalyst; the polymerization reaction is convenient to realize and practicable; raw materials are low in cost, and the industrial production is easy to realize; and the synthesized product is narrow in molecular weight distribution, and the molecular weight can be regulated from 1.0*10<4> to 4.0*10<4>.
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Description

Technical field:

[0001] The invention belongs to the technical field of drug degradable materials, and relates to a process method for synthesizing polylactic acid with high biological safety by using bicyclic guanidine to catalyze lactic acid. Background technique:

[0002] In recent years, with the rapid development of medicine and biomedicine, the demand for degradable materials that can be applied to controlled release and targeted drug carriers, hard tissue repair materials, and bioactive scaffold materials in biological tissue engineering has increased dramatically. Biodegradable polylactic acid has good biocompatibility. As a drug carrier, it can improve drug efficacy, reduce dosage and drug side effects, etc., making it have many important applications in pharmaceutical science and biomedicine. At present, the production of commercialized polylactic acid is mainly synthesized by the ring-opening polycondensation method of stannous octoate and the direct polycondensat...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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