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Microwave assisted preparation of hydroxyapatite hollow sphere

A hydroxyapatite, microwave-assisted technology, applied in phosphorus compounds, nanotechnology for materials and surface science, nanotechnology, etc., can solve the problems of increasing process complexity, production cost, environmental pollution, etc., and achieve good application The effect of prospect, simple preparation process and convenient operation

Active Publication Date: 2013-01-30
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The template added by this method needs to be cleaned in subsequent processing, thus increasing the complexity of the process and production costs, and causing environmental pollution
At present, there are few reports in the literature on the direct synthesis of hydroxyapatite hollow spheres using organic biological phosphorus sources.

Method used

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  • Microwave assisted preparation of hydroxyapatite hollow sphere
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  • Microwave assisted preparation of hydroxyapatite hollow sphere

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] At room temperature, 0.111 g of CaCl 2 Dissolve in 30 ml of deionized water to form liquid A, and dissolve 0.196 g of creatine phosphate sodium salt in 10 ml of deionized water to form liquid B. After adjusting liquid A with 1 mol / L hydrochloric acid to make its pH equal to 5, add liquid B dropwise, and use magnetic stirring during this process to keep the pH at about 5. After the dropwise addition was completed, the mixed clear solution was transferred to a microwave reactor (capacity 60 ml) and reacted at 120 °C for 10 min. After the reaction system was naturally cooled to room temperature, the product was taken out and centrifuged. The separated product was washed three times with deionized water, once with absolute ethanol, and dried in air at 60°C to obtain image 3 The structure of the hydroxyapatite hollow sphere shown is that the hydroxyapatite hollow sphere is assembled by nanosheets, and the diameter of the hollow sphere is about 800 nanometers.

Embodiment 2

[0046] At room temperature, 0.111 g of CaCl 2 Dissolve in 30 ml of deionized water to form liquid A, and dissolve 0.196 g of creatine phosphate sodium salt in 10 ml of deionized water to form liquid B. After adjusting liquid A with 1 mol / L sodium hydroxide to make its pH equal to 10, add liquid B dropwise, and use magnetic stirring during this process to keep the pH at about 10. After the dropwise addition was completed, the mixed clear solution was transferred to a microwave reactor (capacity 60 ml) and reacted at 120 °C for 10 min. After the reaction system was naturally cooled to room temperature, the product was taken out and centrifuged. The separated product was washed three times with deionized water, once with absolute ethanol, and dried in air at 60°C to obtain Figure 4 The calcium phosphate hollow sphere structure shown is assembled from nanosheets, and the average diameter of the hollow spheres is 900 nanometers. see figure 1 It can be known that the calcium pho...

Embodiment 3

[0048] At room temperature, 0.022 g of CaCl 2 Dissolve in 30 ml of deionized water to form liquid A, and dissolve 0.039 g of creatine phosphate sodium salt in 10 ml of deionized water to form liquid B. After adjusting liquid A with 1 mol / L sodium hydroxide to make its pH equal to 10, add liquid B dropwise, and use magnetic stirring during this process to keep the pH at about 10. After the dropwise addition was completed, the mixed clear solution was transferred to a microwave reactor (capacity 60 ml) and reacted at 120 °C for 10 min. After the reaction system was naturally cooled to room temperature, the product was taken out and centrifuged. The separated product was washed three times with deionized water, once with absolute ethanol, and dried in air at 60°C to obtain Figure 5 The structure of the hydroxyapatite hollow sphere shown is that the hydroxyapatite hollow sphere is assembled by nanosheets, and the average diameter of the hollow sphere is 1 micron.

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Abstract

The invention relates to a microwave assisted preparation of hydroxyapatite hollow sphere. The hydroxyapatite hollow sphere structure is prepared from water-soluble calcium salt serving as a calcium source and phosphorous biomolecules serving as a phosphor source through a microwave assisted hydrothermal reaction, wherein the phosphorous biomolecules are phosphocreatine or creatine phosphate. In the hydroxyapatite hollow sphere, the phosphorous biomolecules have good biodegradability and environmental friendliness. The hydroxyapatite hollow sphere structure prepared according to the preparation method provided by the invention can be widely applied to biomedicine, tissue engineering and other fields. The method has important scientific meaning and application value in expanding preparation of calcium phosphate biomaterials.

Description

technical field [0001] The invention relates to a hydroxyapatite hollow sphere and a preparation method thereof. It specifically relates to a preparation method for microwave-assisted synthesis of hydroxyapatite hollow spheres using creatine phosphate or creatine phosphate as a phosphorus source, and belongs to the field of biological material preparation. Background technique [0002] Hydroxyapatite is the main inorganic component of human bones and teeth. The calcium and phosphorus contained in it are essential nutrients for cell growth. Its good biological activity, biocompatibility and biodegradability make it often used in Biomedical fields such as bone substitute materials, dental filling materials, drug delivery carriers, and gene transfection. [0003] Due to different synthesis methods, hydroxyapatite has different crystallinity, size, morphology and physical and chemical properties, so it has different uses. Currently, various methods have been applied to prepare...

Claims

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Application Information

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IPC IPC(8): C01B25/32B82Y40/00B82Y30/00
Inventor 朱英杰漆超陈峰
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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